Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells.

abstract：:The effects of hormonal and dietary stimuli on hepatic glucose and lipid homeostasis include regulation of gene expression. Berberine, an effective compound in certain Chinese medicinal herbs, has been reported to lower plasma glucose and lipid levels in diabetic and hypercholesterolemic patients. We hypothesized that...

journal_title：International journal of biological sciences

authors： Ge Y,Zhang Y,Li R,Chen W,Li Y,Chen G

更新日期：2011-01-01 00:00:00

abstract：:Retrospective and prospective studies show that lean mass or strength is positively associated with metabolic health. Mice deficient in myostatin, a growth factor that negatively regulates skeletal muscle mass, have increased muscle and body weights and are resistant to diet-induced obesity. Their leanness is often at...

journal_title：International journal of biological sciences

authors： Bond ND,Guo J,Hall KD,McPherron AC

更新日期：2016-04-01 00:00:00

abstract：:Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in glioma. Expressions of RRM2 are higher in glioma tissues evidenced by TCGA data, western blot and immunohistoche...

journal_title：International journal of biological sciences

authors： Sun H,Yang B,Zhang H,Song J,Zhang Y,Xing J,Yang Z,Wei C,Xu T,Yu Z,Xu Z,Hou M,Ji M,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

journal_title：International journal of biological sciences

authors： Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

更新日期：2013-05-15 00:00:00

abstract：:Type 2 diabetes mellitus is characterized by insulin resistance. However, the complete molecular mechanism remains unclear. In this study, zebrafish were fed a long-term high-fat diet to induce type 2 diabetes, which resulted in a higher body weight, body mass index, more lipid vacuoles in liver, increased insulin tra...

journal_title：International journal of biological sciences

authors： Meng XH,Chen B,Zhang JP

更新日期：2017-07-18 00:00:00

abstract：:Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A. In this study we aimed to compare both cell lines on applicability in BALs...

journal_title：International journal of biological sciences

authors： van Wenum M,Adam AA,Hakvoort TB,Hendriks EJ,Shevchenko V,van Gulik TM,Chamuleau RA,Hoekstra R

更新日期：2016-06-24 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors. In 1996, we and others identified a superfamily of "regulator of G-protein signaling" (RGS) proteins that acc...

journal_title：International journal of biological sciences

authors： Siderovski DP,Willard FS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel pr...

journal_title：International journal of biological sciences

authors： Lu J,Zhan Y,Feng J,Luo J,Fan S

更新日期：2018-03-10 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition in plants and animals. At present there is relatively little information regarding the role of miRNAs in the response to drought stress in maize. In this study, ...

journal_title：International journal of biological sciences

authors： Sheng L,Chai W,Gong X,Zhou L,Cai R,Li X,Zhao Y,Jiang H,Cheng B

更新日期：2015-05-22 00:00:00

abstract：:Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

journal_title：International journal of biological sciences

authors： Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

更新日期：2019-11-01 00:00:00

abstract：:Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this study, recombinant lentiviral vectors coding for ZIKV structural proteins and truncations (prM-Env, M-En...

journal_title：International journal of biological sciences

authors： Liu J,Li Q,Li X,Qiu Z,Li A,Liang W,Chen H,Cai X,Chen X,Duan X,Li J,Wu W,Xu M,Mao Y,Chen H,Li J,Gu W,Li H

更新日期：2018-06-08 00:00:00

abstract：:The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: ...

journal_title：International journal of biological sciences

authors： Quintero-Gutiérrez AG,González-Rosendo G,Sánchez-Muñoz J,Polo-Pozo J,Rodríguez-Jerez JJ

更新日期：2008-02-18 00:00:00

abstract：:The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent years and is now relatively established. Here we discuss the role...

journal_title：International journal of biological sciences

authors： Thornton TM,Rincon M

更新日期：2009-01-01 00:00:00

abstract：:β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in C2C12 myoblasts. This effect is partly due to the enhanced stability of p27, r...

journal_title：International journal of biological sciences

authors： Chen M,Liu C,Wang M,Wang H,Zhang K,Zheng Y,Yu Z,Li X,Guo W,Li N,Meng Q

更新日期：2017-10-17 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...

journal_title：International journal of biological sciences

authors： Li H,Zhang X,Qi X,Zhu X,Cheng L

更新日期：2019-01-01 00:00:00

abstract：:CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

journal_title：International journal of biological sciences

authors： Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

更新日期：2019-09-07 00:00:00

abstract：:Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB) which leads to infiltration of blood cells, an inflammatory response, and neuronal cell death, resulting spinal cord secondary damage. Retinoic acid (RA) has a neuroprotective effect in both ischemic brain injury and SCI, however t...

journal_title：International journal of biological sciences

authors： Zhou Y,Zhang H,Zheng B,Ye L,Zhu S,Johnson NR,Wang Z,Wei X,Chen D,Cao G,Fu X,Li X,Xu HZ,Xiao J

更新日期：2016-01-01 00:00:00

abstract：:Proteomic profiling of the pectoralis muscle of Thai indigenous chickens during growth period was analyzed using two-dimensional gel electrophoresis (2-DE) and matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF/MS). A total of 259, 161, 120 and 107 protein spots were found to be ex...

journal_title：International journal of biological sciences

authors： Teltathum T,Mekchay S

更新日期：2009-10-28 00:00:00

abstract：:Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elu...

journal_title：International journal of biological sciences

authors： Liu F,Xia Z,Zhang M,Ding J,Feng Y,Wu J,Dong Y,Gao W,Han Z,Liu Y,Yao Y,Li D

更新日期：2019-01-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...

journal_title：International journal of biological sciences

authors： Pisa D,Alonso R,Carrasco L

更新日期：2020-02-10 00:00:00

abstract：:A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evident...

journal_title：International journal of biological sciences

authors： Langeland JA,Holland LZ,Chastain RA,Holland ND

更新日期：2006-01-01 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

journal_title：International journal of biological sciences

authors： Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...

journal_title：International journal of biological sciences

authors： Qu W,Xiao J,Zhang H,Chen Q,Wang Z,Shi H,Gong L,Chen J,Liu Y,Cao R,Lv J

更新日期：2013-08-14 00:00:00

abstract：:Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

journal_title：International journal of biological sciences

authors： Zhang Q,Dong J,Yu Z

更新日期：2020-08-13 00:00:00

abstract：:To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...

journal_title：International journal of biological sciences

authors： Dai J,Li Y,Zhou H,Chen J,Chen M,Xiao Z

更新日期：2013-11-21 00:00:00

abstract：:Thymosin alpha 1 (Tα1) has immunomodulatory and anti-tumor effects in patients and has been commercialized in worldwide. An innovative technique is therefore impending to achieve high-yield expression and purification of Tα1 to meet the increasing requirements for clinical applications. Tα1 can enhance T cells, dendri...

journal_title：International journal of biological sciences

authors： Li W,Song L,Wu S,Xue X,Zhang L,He L,Han W,Wang Q,Ling R,Zhang W,Yan Z,Zhang Y

更新日期：2011-01-01 00:00:00

abstract：:Protein Kinase D3 (PRKD3) functions as an important oncogenic driver in invasive breast cancer, which is the leading cause of women mortality. However, PRKD3 regulating network is largely unknown. In this study, we systematically explored PRKD3 regulating networks via investigating phosphoproteome, interactome and tra...

journal_title：International journal of biological sciences

authors： Liu Y,Li J,Zhang J,Yu Z,Yu S,Wu L,Wang Y,Gong X,Wu C,Cai X,Mo L,Wang M,Gu J,Chen L

更新日期：2017-05-16 00:00:00