当前位置： SCI文献检索 > International Journal of Biological Sciences期刊下所有文献 > Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling.

Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling.

Abstract：

:β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in C2C12 myoblasts. This effect is partly due to the enhanced stability of p27, rather than the increased gene transcription via cAMP response element-binding protein (CREB). Specifically, CLB treatment enhanced the accumulation of p27 in the nucleus while depleting it from the cytosol via a mechanism that requires β2-AR. Surprisingly, p27 accumulation was not reversed by the protein kinase A (PKA) inhibitor H-89, but interestingly, was alleviated by the knockdown of β-arrestin 2. Thus, our work provides a basis for β2-AR agonists inhibit myoblasts proliferation through signaling via β2-AR, β-arrestin 2, and p27.

journal_name

Int J Biol Sci

journal_title

International journal of biological sciences

authors

Chen M,Liu C,Wang M,Wang H,Zhang K,Zheng Y,Yu Z,Li X,Guo W,Li N,Meng Q

doi

10.7150/ijbs.17948

subject

Has Abstract

pub_date

2017-10-17 00:00:00

pages

1341-1350

issue

10

issn

1449-2288

pii

ijbsv13p1341

journal_volume

13

pub_type

杂志文章

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