Abstract:
:N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by m6A binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers). Accumulating evidence shows that m6A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses. In this review, we mainly summarize and discuss the functional relevance and importance of m6A modification in cellular processes.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Zhu ZM,Huo FC,Pei DSdoi
10.7150/ijbs.45231subject
Has Abstractpub_date
2020-04-15 00:00:00pages
1929-1940issue
11issn
1449-2288pii
ijbsv16p1929journal_volume
16pub_type
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