Abstract:
:Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies indicate the transplanted cells exert therapeutic effects primarily via a paracrine mechanism and exosomes are an important paracrine factor that can be directly used as therapeutic agents for tissue engineering. Herein, we provided the first demonstration that the early treatment of exosomes secreted by human synovial-derived mesenchymal stem cells (SMSC-Exos) could prevent GC-induced ONFH in the rat model. Using a series of in vitro functional assays, we found that SMSC-Exos could be internalized into bone marrow derived stromal cells (BMSCs) and enhance their proliferation and have anti-apoptotic abilities. Finally, SMSC-Exos may be promising for preventing GC-induced ONFH.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Guo SC,Tao SC,Yin WJ,Qi X,Sheng JG,Zhang CQdoi
10.7150/ijbs.16150subject
Has Abstractpub_date
2016-10-17 00:00:00pages
1262-1272issue
10issn
1449-2288pii
ijbsv12p1262journal_volume
12pub_type
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