miR-1204 promotes hepatocellular carcinoma progression through activating MAPK and c-Jun/AP1 signaling by targeting ZNF418.

abstract：:Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell ...

journal_title：International journal of biological sciences

authors： López-Navarrete G,Ramos-Martínez E,Suárez-Álvarez K,Aguirre-García J,Ledezma-Soto Y,León-Cabrera S,Gudiño-Zayas M,Guzmán C,Gutiérrez-Reyes G,Hernández-Ruíz J,Camacho-Arroyo I,Robles-Díaz G,Kershenobich D,Terrazas LI,Escobedo

更新日期：2011-01-01 00:00:00

abstract：:It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...

journal_title：International journal of biological sciences

authors： Cai H,Li X,Li J,Liang Q,Zheng W,Guan Q,Guo Z,Wang X

更新日期：2018-05-22 00:00:00

abstract：:Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...

journal_title：International journal of biological sciences

authors： Zhao W,Ma L,Cai C,Gong X

更新日期：2019-06-02 00:00:00

abstract：:Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in...

journal_title：International journal of biological sciences

authors： Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PC

更新日期：2020-01-01 00:00:00

abstract：:The cephalochordate amphioxus occupies a central place in evolutionary thoughts to the origin of Vertebrates. With a prototypical vertebrate-like body plan and a preduplicative genome, the friendly lancelet seems to be in morphological and genetic motionless since its separation from the major branch of evolution that...

journal_title：International journal of biological sciences

authors： Garcia-Fernàndez J

更新日期：2006-01-01 00:00:00

abstract：:Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform pa...

journal_title：International journal of biological sciences

authors： Verkerk AO,Wilders R,van Borren MM,Tan HL

更新日期：2009-01-01 00:00:00

abstract：:Angiogenesis plays an important role in myocardial repair after myocardial infarction (MI). Cardiac micro-vascular endothelial cells (CMECs) are important participants in myocardial angiogenesis processes. Recent studies have revealed that Nuclear factor-erythroid 2-related factor 2 (Nrf2), a master transcription fact...

journal_title：International journal of biological sciences

authors： Kuang L,Feng J,He G,Jing T

更新日期：2013-07-07 00:00:00

abstract：:Germ cells produce sperm and eggs for reproduction and fertility. The Asian seabass (Lates calcarifer), a protandrous marine fish, undergoes male-female sex reversal and thus offers an excellent model to study the role of germ cells in sex differentiation and sex reversal. Here we report the cloning and expression of ...

journal_title：International journal of biological sciences

authors： Xu H,Lim M,Dwarakanath M,Hong Y

更新日期：2014-02-06 00:00:00

abstract：:The gene encoding PDX1 (pancreatic duodenum homeobox 1), the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic beta-cells, clusters with two closely related homeobox genes (Gsh1 and Cdx2/3), all of them belonging to the ParaHox gene family. The ParaHox gen...

journal_title：International journal of biological sciences

authors： Rosanas-Urgell A,Garcia-Fernàndez J,Marfany G

更新日期：2008-02-06 00:00:00

abstract：:Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elu...

journal_title：International journal of biological sciences

authors： Liu F,Xia Z,Zhang M,Ding J,Feng Y,Wu J,Dong Y,Gao W,Han Z,Liu Y,Yao Y,Li D

更新日期：2019-01-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:Mast cells are found abundant at sites of acupoints. Nerve cells share perivascular localization with mast cells. Acupuncture (mechanical stimuli) can activate mast cells to release adenosine triphosphate (ATP) which can activate nerve cells and modulates pain-processing pathways in response to acupuncture. In this pa...

journal_title：International journal of biological sciences

authors： Yao W,Yang H,Yin N,Ding G

更新日期：2014-04-26 00:00:00

abstract：:Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect neuronal cells against oxidative stress in neurodegenerative diseases. The present study was designed to examine whether CoQ10 was capable of protecting astrocytes from reactive oxygen species (ROS) mediated damage. For this purpose, ultraviole...

journal_title：International journal of biological sciences

authors： Jing L,He MT,Chang Y,Mehta SL,He QP,Zhang JZ,Li PA

更新日期：2015-01-01 00:00:00

abstract：:BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues....

journal_title：International journal of biological sciences

authors： Baek HJ,Kim SE,Choi EK,Kim JK,Shin DH,Park EJ,Kim TH,Kim JY,Kim KG,Deng CX,Kim SS

更新日期：2018-10-03 00:00:00

abstract：:Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

journal_title：International journal of biological sciences

authors： Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

更新日期：2014-03-10 00:00:00

abstract：:Well-orchestrated epigenetic modifications during early development are essential for embryonic survival and postnatal growth. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term ...

journal_title：International journal of biological sciences

authors： Fu W,Yue Y,Miao K,Xi G,Zhang C,Wang W,An L,Tian J

更新日期：2020-10-03 00:00:00

abstract：:Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative approaches in muscle regeneration. The aim of the study was to demonstrate cryogel scaffold potential in the field of ...

journal_title：International journal of biological sciences

authors： Singh D,Nayak V,Kumar A

更新日期：2010-07-03 00:00:00

abstract：:Reverting activated hepatic stellate cells (HSCs) to less activation or quiescent status is a promising strategy for liver fibrosis. Histone deacetylase inhibitor (HDACI) could suppress HSCs activation. Our previous study demonstrated a critical role of miRNAs in HSCs activation. Here, we explored the involvement of m...

journal_title：International journal of biological sciences

authors： Lu P,Yan M,He L,Li J,Ji Y,Ji J

更新日期：2019-01-06 00:00:00

abstract：:Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...

journal_title：International journal of biological sciences

authors： Rao F,Wang T,Li M,Li Z,Hong N,Zhao H,Yan Y,Lu W,Chen T,Wang W,Lim M,Yuan Y,Liu L,Zeng L,Wei Q,Guan G,Li C,Hong Y

更新日期：2011-04-15 00:00:00

abstract：:The evading apoptosis of tumor cells may result in chemotherapy resistance. Therefore, investigating what molecular events contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity. In this study, we foc...

journal_title：International journal of biological sciences

authors： Ji Y,Shen J,Li M,Zhu X,Wang Y,Ding J,Jiang S,Chen L,Wei W

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Oridonin (ORI) could inhibit the proliferation and induce apoptosis in various cancer cell lines. However, the mechanism is not fully understood. METHODS:Human prostate cancer (HPC) cells were cultured in vitro and cell viability was detected by the CCK-8 assay. The ultrastructure changes were observed unde...

journal_title：International journal of biological sciences

authors： Li X,Li X,Wang J,Ye Z,Li JC

更新日期：2012-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Ferroptosis, an iron-dependent form of regulated cell death, can be induced by sorafenib. However, the prognostic value of ferroptosis-related genes in HCC remains to be further elucidated. In this stud...

journal_title：International journal of biological sciences

authors： Liang JY,Wang DS,Lin HC,Chen XX,Yang H,Zheng Y,Li YH

更新日期：2020-07-06 00:00:00

abstract：:Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head (ONFH), and vitamin K2 (VK2) has been shown to play an important and beneficial role in bone metabolism. In this study, we hypothesized that VK2 could decrease the incidence of glucocorticoid-induced ONFH in a ra...

journal_title：International journal of biological sciences

authors： Zhang YL,Yin JH,Ding H,Zhang W,Zhang CQ,Gao YS

更新日期：2016-01-28 00:00:00

abstract：BACKGROUND & OBJECTIVE:The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel pr...

journal_title：International journal of biological sciences

authors： Lu J,Zhan Y,Feng J,Luo J,Fan S

更新日期：2018-03-10 00:00:00

abstract：:Bluetongue virus (BTV) replicates in lymphoid tissues where infected mononuclear leukocytes secrete proinflammatory and vasoactive mediators that can contribute to bluetongue (BT) pathogenesis. Using the well-characterized IFNAR(-/-) mice animal model, we have now studied the histopathology and dynamics of leukocyte p...

journal_title：International journal of biological sciences

authors： Marín-López A,Bermúdez R,Calvo-Pinilla E,Moreno S,Brun A,Ortego J

更新日期：2016-11-24 00:00:00

abstract：:Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...

journal_title：International journal of biological sciences

authors： Wu YL,Ding YP,Tanaka Y,Shen LW,Wei CH,Minato N,Zhang W

更新日期：2014-01-10 00:00:00

abstract：:The vertebrate body plan externally is largely symmetrical across the midline but internal organs develop asymmetrically. The biological basis of asymmetric organ development has been investigated extensively for years, although the proposed mechanisms remain controversial. By comparison, the biological origin of exte...

journal_title：International journal of biological sciences

authors： Klar AJ

更新日期：2014-09-10 00:00:00

abstract：:Thymosin alpha 1 (Tα1) has immunomodulatory and anti-tumor effects in patients and has been commercialized in worldwide. An innovative technique is therefore impending to achieve high-yield expression and purification of Tα1 to meet the increasing requirements for clinical applications. Tα1 can enhance T cells, dendri...

journal_title：International journal of biological sciences

authors： Li W,Song L,Wu S,Xue X,Zhang L,He L,Han W,Wang Q,Ling R,Zhang W,Yan Z,Zhang Y

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...

journal_title：International journal of biological sciences

authors： Helms SA,Azhar G,Zuo C,Theus SA,Bartke A,Wei JY

更新日期：2010-09-01 00:00:00

abstract：:Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to eva...

journal_title：International journal of biological sciences

authors： Wang L,Wei W,Xiao Q,Yang H,Ci X

更新日期：2019-01-29 00:00:00