Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions.

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:The gene encoding PDX1 (pancreatic duodenum homeobox 1), the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic beta-cells, clusters with two closely related homeobox genes (Gsh1 and Cdx2/3), all of them belonging to the ParaHox gene family. The ParaHox gen...

journal_title：International journal of biological sciences

authors： Rosanas-Urgell A,Garcia-Fernàndez J,Marfany G

更新日期：2008-02-06 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...

journal_title：International journal of biological sciences

authors： Yao H,Teng Y,Sun Q,Xu J,Chen YT,Hou N,Cheng X,Yang X,Chen ZN

更新日期：2013-12-13 00:00:00

abstract：:MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors. Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. In this study, we rep...

journal_title：International journal of biological sciences

authors： Zhang W,Duan N,Zhang Q,Song T,Li Z,Zhang C,Chen X,Wang K

更新日期：2017-04-10 00:00:00

abstract：:Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to eva...

journal_title：International journal of biological sciences

authors： Wang L,Wei W,Xiao Q,Yang H,Ci X

更新日期：2019-01-29 00:00:00

abstract：:Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...

journal_title：International journal of biological sciences

authors： Cao P,Xia Y,He W,Zhang T,Hong L,Zheng P,Shen X,Liang G,Cui R,Zou P

更新日期：2019-06-04 00:00:00

abstract：:This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). In this study, GDM model was induced in late pregnant rat model. The alteration of ClC-2 expression in various ...

journal_title：International journal of biological sciences

authors： He F,Peng Y,Yang Z,Ge Z,Tian Y,Ma T,Li H

更新日期：2017-01-15 00:00:00

abstract：:The terminal loop region of primary miRNA transcripts is an important determinant controlling miRNA function in human, animals and plants. However, the effects of polymorphisms in loop region of miRNA precusors on phenotypic variation have not been reported, especially on agronomic traits in rice. From rice japonica v...

journal_title：International journal of biological sciences

authors： Wang C,Ye J,Tang W,Liu Z,Zhu C,Wang M,Wan J

更新日期：2013-06-16 00:00:00

abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

journal_title：International journal of biological sciences

authors： Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

更新日期：2018-01-01 00:00:00

abstract：:Emerging evidence has indicated that abnormal microRNAs (miRNAs) participated in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Better understanding the association between miRNAs and HCC may contribute to discover novel therapeutic approaches for diagnosis and treatments. In the current study...

journal_title：International journal of biological sciences

authors： Wang L,Sun L,Wang Y,Yao B,Liu R,Chen T,Tu K,Liu Q,Liu Z

更新日期：2019-06-02 00:00:00

abstract：:In order to find a blood host and to select appropriate oviposition sites female Anopheles gambiae mosquitoes rely on olfactory cues which are sensed by olfactory sensory neurons (OSNs) located within morphologically different sensilla hairs. While the sharp type trichoid sensilla are most abundant and intensely studi...

journal_title：International journal of biological sciences

authors： Schultze A,Breer H,Krieger J

更新日期：2014-03-22 00:00:00

abstract：:Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and ...

journal_title：International journal of biological sciences

authors： Wang Y,Wang J,Deng Z,Jin J,Jiang H,Meng J,Xu H,Zhao J,Sun G,Qian H

更新日期：2017-09-05 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

journal_title：International journal of biological sciences

authors： Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

更新日期：2019-07-25 00:00:00

abstract：:Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn...

journal_title：International journal of biological sciences

authors： Wu JR,Yeh JL,Liou SF,Dai ZK,Wu BN,Hsu JH

更新日期：2016-07-18 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam ...

journal_title：International journal of biological sciences

authors： Song X,Fischer P,Chen X,Burton C,Wang J

更新日期：2009-10-09 00:00:00

abstract：:Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple organs and are characterized by hyperglycaemia. Currently, stable and effective treatments for obesity and type 2 diabetes mellitus are not available. Therefore, the mechanisms leading to obesity and diabetes and more effectiv...

journal_title：International journal of biological sciences

authors： Huang X,Liu G,Guo J,Su Z

更新日期：2018-08-06 00:00:00

abstract：:Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...

journal_title：International journal of biological sciences

authors： Xiao Q,Xia JH,Zhang XJ,Li Z,Wang Y,Zhou L,Gui JF

更新日期：2014-06-24 00:00:00

abstract：OBJECTIVES:Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. We aimed to evaluate the relationship of MDA and GPx levels wit...

journal_title：International journal of biological sciences

authors： Hsieh YY,Chang CC,Lin CS

更新日期：2006-01-01 00:00:00

abstract：:The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in multiple types of tum...

journal_title：International journal of biological sciences

authors： Chen Z,Liu J,Chu D,Shan Y,Ma G,Zhang H,Zhang XD,Wang P,Chen Q,Deng C,Chen W,Dimitrov DS,Zhao Q

更新日期：2018-05-21 00:00:00

abstract：:Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform pa...

journal_title：International journal of biological sciences

authors： Verkerk AO,Wilders R,van Borren MM,Tan HL

更新日期：2009-01-01 00:00:00

abstract：:Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

journal_title：International journal of biological sciences

authors： Yang N,Shen HM

更新日期：2020-03-15 00:00:00

abstract：:Mitochondrial function is of particular importance in brain because of its high demand for energy (ATP) and efficient removal of reactive oxygen species (ROS). We developed rat mitochondrion-neuron focused microarray (rMNChip) and integrated bioinformatics tools for rapid identification of differential pathways in bra...

journal_title：International journal of biological sciences

authors： Su YA,Zhang Q,Su DM,Tang MX

更新日期：2011-03-29 00:00:00

abstract：:Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...

journal_title：International journal of biological sciences

authors： Min H,Lee JY,Kim MH

更新日期：2012-01-01 00:00:00

abstract：:Pathological cardiac hypertrophy is the response of heart to various biomechanical and physiopathological stimuli, such as aging, myocardial ischemia and hypertension. However, a long-term exposure to the stress makes heart progress to heart failure. Autophagy is a dynamic self-degradative process necessary for the ma...

journal_title：International journal of biological sciences

authors： Li Z,Wang J,Yang X

更新日期：2015-04-27 00:00:00

abstract：:Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed. These therapeutic responses are t...

journal_title：International journal of biological sciences

authors： Zhang W,Meng Y,Liu N,Wen XF,Yang T

更新日期：2015-08-01 00:00:00

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：:As one of the most ominous malignancies, hepatocellular carcinoma (HCC) is frequently diagnosed at an advanced stage, owing to its aggressive invasion and metastatic spread. Emerging evidence has demonstrated that Rictor, as a unique component of the mTORC2, plays a role in cell migration, as it is dysregulated in var...

journal_title：International journal of biological sciences

authors： Dong X,Feng M,Yang H,Liu H,Guo H,Gao X,Liu Y,Liu R,Zhang N,Chen R,Kong R

更新日期：2020-09-01 00:00:00