Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.

abstract：:The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global infection, and is seriously threatening human life, especially cancer patients. Thus, we sought to determine the clinical roles of ACE2 (the cell entry receptor of SARS-CoV-2) in ccRCC (clear cell renal cell carcinoma). TCGA, ...

journal_title：International journal of biological sciences

authors： Yang W,Li L,Zhang K,Ma K,Xie H,Gong Y,Zhou J,Gong K

更新日期：2021-01-01 00:00:00

abstract：:The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in multiple types of tum...

journal_title：International journal of biological sciences

authors： Chen Z,Liu J,Chu D,Shan Y,Ma G,Zhang H,Zhang XD,Wang P,Chen Q,Deng C,Chen W,Dimitrov DS,Zhao Q

更新日期：2018-05-21 00:00:00

abstract：:During the immune response, neutrophils display localized mechanical events by interacting with their environment through the micro-vascular transit, trans-endothelial, and trans-epithelial migration. Nano-mechanical studies of human neutrophils on localized nano-domains could provide the essential information for und...

journal_title：International journal of biological sciences

authors： Lee YJ,Patel D,Park S

更新日期：2011-01-20 00:00:00

abstract：:The objective of this study was to study the effect of diabetic hyperglycemia on astrocytes after forebrain ischemia. Streptozotocin (STZ)-injected hyperglycemic and vehicle-injected normoglycemic rats were subjected to 15 minutes of forebrain ischemia. The brains were harvested in sham-operated controls and in animal...

journal_title：International journal of biological sciences

authors： Jing L,Mai L,Zhang JZ,Wang JG,Chang Y,Dong JD,Guo FY,Li PA

更新日期：2013-09-25 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) wild-type is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs). In this study, we assessed whether the combination of bisdemethoxycurcumin (BDMC) and icotinib could surmount primary EGFR-TKI resistance in NSCLC cells and inves...

journal_title：International journal of biological sciences

authors： Xiang M,Jiang HG,Shu Y,Chen YJ,Jin J,Zhu YM,Li MY,Wu JN,Li J

更新日期：2020-03-05 00:00:00

abstract：:MiR-216a-5p has opposite effects on tumorigenesis and progression in the context of different tumors, acting as either a tumor suppressor or an oncogene. However, the expression and function of miR-216a-5p in pancreatic cancer (PC) is not well characterized. In this study, we found miR-216a-5p was significantly downre...

journal_title：International journal of biological sciences

authors： Zhang J,Gao S,Zhang Y,Yi H,Xu M,Xu J,Liu H,Ding Z,He H,Wang H,Hao Z,Sun L,Liu Y,Wei F

更新日期：2020-07-19 00:00:00

abstract：:Genetic variant T329S in flavin-containing monooxygenase 3 (FMO3) impairs trimethylamine (TMA) metabolism in birds. The TMA metabolism that under complex genetic and dietary regulation, closely linked to cardiovascular disease risk. We determined whether the genetic defects in TMA metabolism may change other metabolic...

journal_title：International journal of biological sciences

authors： Wang J,Long C,Zhang H,Zhang Y,Wang H,Yue H,Wang X,Wu S,Qi G

更新日期：2016-10-25 00:00:00

abstract：:Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to eva...

journal_title：International journal of biological sciences

authors： Wang L,Wei W,Xiao Q,Yang H,Ci X

更新日期：2019-01-29 00:00:00

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...

journal_title：International journal of biological sciences

authors： Helms SA,Azhar G,Zuo C,Theus SA,Bartke A,Wei JY

更新日期：2010-09-01 00:00:00

abstract：:Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...

journal_title：International journal of biological sciences

authors： Yao H,Teng Y,Sun Q,Xu J,Chen YT,Hou N,Cheng X,Yang X,Chen ZN

更新日期：2013-12-13 00:00:00

abstract：:Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma and play an essential role in tumor progression and metastasis in a variety of malignancies, including gastric cancer. However, the effects of CAFs on gastr...

journal_title：International journal of biological sciences

authors： Xu G,Zhang B,Ye J,Cao S,Shi J,Zhao Y,Wang Y,Sang J,Yao Y,Guan W,Tao J,Feng M,Zhang W

更新日期：2019-08-22 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies in...

journal_title：International journal of biological sciences

authors： Guo SC,Tao SC,Yin WJ,Qi X,Sheng JG,Zhang CQ

更新日期：2016-10-17 00:00:00

abstract：:Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the A...

journal_title：International journal of biological sciences

authors： Cui H,Guo S,He H,Guo H,Zhang Y,Wang B

更新日期：2020-02-10 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases....

journal_title：International journal of biological sciences

authors： Wang H,Lafdil F,Kong X,Gao B

更新日期：2011-04-27 00:00:00

abstract：:It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...

journal_title：International journal of biological sciences

authors： Cai H,Li X,Li J,Liang Q,Zheng W,Guan Q,Guo Z,Wang X

更新日期：2018-05-22 00:00:00

abstract：:Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...

journal_title：International journal of biological sciences

authors： Xiao Q,Xia JH,Zhang XJ,Li Z,Wang Y,Zhou L,Gui JF

更新日期：2014-06-24 00:00:00

abstract：:Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs) were thereafter add...

journal_title：International journal of biological sciences

authors： Hayashi K,Tatsui T,Shimanouchi T,Umakoshi H

更新日期：2013-01-01 00:00:00

abstract：:Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

journal_title：International journal of biological sciences

authors： Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

更新日期：2018-11-03 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00

abstract：:Background: The monitoring and management of blood glucose concentration are standard practices in critical settings as hyperglycaemia has been shown close association with poorer outcomes. Several meta-analyses have revealed that intensive glucose control has no benefit in decreasing short-term mortality among critic...

journal_title：International journal of biological sciences

authors： Yao RQ,Ren C,Wu GS,Zhu YB,Xia ZF,Yao YM

更新日期：2020-03-12 00:00:00

abstract：:RNA interference has been described as a powerful genetic tool for gene functional analysis and a promising approach for pest management. However, RNAi efficiency varies significantly among insect species due to distinct RNAi machineries. Lepidopteran insects include a large number of pests as well as model insects, s...

journal_title：International journal of biological sciences

authors： Li Z,Zeng B,Ling L,Xu J,You L,Aslam AF,Tan A,Huang Y

更新日期：2015-01-05 00:00:00

abstract：:Chronic back pain is a global health problem affecting millions of people worldwide and carries significant economic and social morbidities. Intervertebral disc damage and degeneration is a major cause of back pain, characterised by histological and biochemical changes that have been well documented in animal models. ...

journal_title：International journal of biological sciences

authors： Wei A,Williams LA,Bhargav D,Shen B,Kishen T,Duffy N,Diwan AD

更新日期：2009-06-03 00:00:00

abstract：:Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

journal_title：International journal of biological sciences

authors： Zhang Q,Dong J,Yu Z

更新日期：2020-08-13 00:00:00

abstract：BACKGROUND:Increasing evidences suggest that innate immunity is involved in cerebral ischemia-reperfusion (I/R) injury, but the liable innate immune receptors have not been completely elucidated. Here, we explored the role of the nucleotide-binding oligomerization domain (NOD)2, a member of the cytosolic NOD-like recep...

journal_title：International journal of biological sciences

authors： Liu H,Wei X,Kong L,Liu X,Cheng L,Yan S,Zhang X,Chen L

更新日期：2015-03-25 00:00:00

abstract：:Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...

journal_title：International journal of biological sciences

authors： Wu YL,Ding YP,Tanaka Y,Shen LW,Wei CH,Minato N,Zhang W

更新日期：2014-01-10 00:00:00

abstract：:In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

journal_title：International journal of biological sciences

authors： Yao W,Shen Z,Ding G

更新日期：2013-11-05 00:00:00

abstract：:Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...

journal_title：International journal of biological sciences

authors： Pisa D,Alonso R,Carrasco L

更新日期：2020-02-10 00:00:00

abstract：:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

journal_title：International journal of biological sciences

authors： Tian J,Casella G,Zhang Y,Rostami A,Li X

更新日期：2020-01-01 00:00:00

abstract：:Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed. These therapeutic responses are t...

journal_title：International journal of biological sciences

authors： Zhang W,Meng Y,Liu N,Wen XF,Yang T

更新日期：2015-08-01 00:00:00