Genetic Variant in Flavin-Containing Monooxygenase 3 Alters Lipid Metabolism in Laying Hens in a Diet-Specific Manner.

abstract：:Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were en...

journal_title：International journal of biological sciences

authors： Jeong S,Zheng B,Wang J,Chi J,Tong Y,Xia L,Xu N,Zhang J,Kong X,Gu J,Xia Q

更新日期：2017-09-21 00:00:00

abstract：:Mast cells are found abundant at sites of acupoints. Nerve cells share perivascular localization with mast cells. Acupuncture (mechanical stimuli) can activate mast cells to release adenosine triphosphate (ATP) which can activate nerve cells and modulates pain-processing pathways in response to acupuncture. In this pa...

journal_title：International journal of biological sciences

authors： Yao W,Yang H,Yin N,Ding G

更新日期：2014-04-26 00:00:00

abstract：:Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human...

journal_title：International journal of biological sciences

authors： Huang A,Dong J,Li S,Wang C,Ding H,Li H,Su X,Ge X,Sun L,Bai C,Shen X,Fang T,Li J,Shao N

更新日期：2015-06-11 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased i...

journal_title：International journal of biological sciences

authors： Chu C,Liu X,Bai X,Zhao T,Wang M,Xu R,Li M,Hu Y,Li W,Yang L,Qin Y,Yang M,Yan C,Zhang Y

更新日期：2018-02-09 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

journal_title：International journal of biological sciences

authors： Guan R,Wen X,Liang Y,Xu D,He B,Feng X

更新日期：2019-08-06 00:00:00

abstract：: Objectives: Skeletal development is a complex process. Little is known about the different response of limb or spine growth plate chondrocytes (LGP or SGP) to the estrogen level and the role of estrogen receptor (ER) during postnatal stage. Methods...

journal_title：International journal of biological sciences

authors： Shi S,Zheng S,Li XF,Liu ZD

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Oridonin (ORI) could inhibit the proliferation and induce apoptosis in various cancer cell lines. However, the mechanism is not fully understood. METHODS:Human prostate cancer (HPC) cells were cultured in vitro and cell viability was detected by the CCK-8 assay. The ultrastructure changes were observed unde...

journal_title：International journal of biological sciences

authors： Li X,Li X,Wang J,Ye Z,Li JC

更新日期：2012-01-01 00:00:00

abstract：:Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

journal_title：International journal of biological sciences

authors： Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

更新日期：2018-11-03 00:00:00

abstract：:Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide. Glycosphingolipids (GSLs) are involved in virus infection by regulating various steps of viral-host interaction. However, the distinct role of GSLs during DENV infection remains unclear. In this study, we used mouse melano...

journal_title：International journal of biological sciences

authors： Wang K,Wang J,Sun T,Bian G,Pan W,Feng T,Wang P,Li Y,Dai J

更新日期：2016-05-25 00:00:00

abstract：:Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head (ONFH), and vitamin K2 (VK2) has been shown to play an important and beneficial role in bone metabolism. In this study, we hypothesized that VK2 could decrease the incidence of glucocorticoid-induced ONFH in a ra...

journal_title：International journal of biological sciences

authors： Zhang YL,Yin JH,Ding H,Zhang W,Zhang CQ,Gao YS

更新日期：2016-01-28 00:00:00

abstract：:Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...

journal_title：International journal of biological sciences

authors： Min H,Lee JY,Kim MH

更新日期：2012-01-01 00:00:00

abstract：:Genuine racial differences in prostate cancer (PCa) biology have been considered among the potential reasons to explain PCa disparities. There is no animal model to represent all aspects of human PCa and, more specifically, to be used for PCa disparity research. The lack of a spontaneously transformed in vitro cell-ba...

journal_title：International journal of biological sciences

authors： Koochekpour S,Willard SS,Shourideh M,Ali S,Liu C,Azabdaftari G,Saleem M,Attwood K

更新日期：2014-07-26 00:00:00

abstract：:Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout ...

journal_title：International journal of biological sciences

authors： Cameron DJ,Tong Z,Yang Z,Kaminoh J,Kamiyah S,Chen H,Zeng J,Chen Y,Luo L,Zhang K

更新日期：2007-02-06 00:00:00

abstract：:Background: The monitoring and management of blood glucose concentration are standard practices in critical settings as hyperglycaemia has been shown close association with poorer outcomes. Several meta-analyses have revealed that intensive glucose control has no benefit in decreasing short-term mortality among critic...

journal_title：International journal of biological sciences

authors： Yao RQ,Ren C,Wu GS,Zhu YB,Xia ZF,Yao YM

更新日期：2020-03-12 00:00:00

abstract：:Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs) were thereafter add...

journal_title：International journal of biological sciences

authors： Hayashi K,Tatsui T,Shimanouchi T,Umakoshi H

更新日期：2013-01-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam ...

journal_title：International journal of biological sciences

authors： Song X,Fischer P,Chen X,Burton C,Wang J

更新日期：2009-10-09 00:00:00

abstract：OBJECTIVES:Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. We aimed to evaluate the relationship of MDA and GPx levels wit...

journal_title：International journal of biological sciences

authors： Hsieh YY,Chang CC,Lin CS

更新日期：2006-01-01 00:00:00

abstract：:Gene silencing techniques are widely used to control gene expression and have potential for RNAi-based therapeutics. In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter. ...

journal_title：International journal of biological sciences

authors： Ajiro M,Jia R,Wang RH,Deng CX,Zheng ZM

更新日期：2015-09-03 00:00:00

abstract：:β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in C2C12 myoblasts. This effect is partly due to the enhanced stability of p27, r...

journal_title：International journal of biological sciences

authors： Chen M,Liu C,Wang M,Wang H,Zhang K,Zheng Y,Yu Z,Li X,Guo W,Li N,Meng Q

更新日期：2017-10-17 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

journal_title：International journal of biological sciences

authors： Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

更新日期：2020-02-04 00:00:00

abstract：:The standard of care for patients who suffer from non-organ confined prostate cancer (CaP) is androgen deprivation therapy (ADT). ADT exploits the reliance of CaP cells on androgen receptor (AR) signaling throughout CaP progression from androgen-stimulated (AS) to castration-recurrent (CR) disease. AR is a member of t...

journal_title：International journal of biological sciences

authors： Heemers HV

更新日期：2014-06-01 00:00:00

abstract：:Hyperglycemia is known to exacerbate neuronal death resulted from cerebral ischemia. The mechanisms are not fully understood. The mammalian target of rapamycin (mTOR) pathway regulates cell growth, division and apoptosis. Recent studies suggest that activation of mTOR may mediate ischemic brain damage. The objective o...

journal_title：International journal of biological sciences

authors： Hei C,Liu P,Yang X,Niu J,Li PA

更新日期：2017-07-07 00:00:00

abstract：:Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

journal_title：International journal of biological sciences

authors： Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

更新日期：2018-04-05 00:00:00

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

journal_title：International journal of biological sciences

authors： Tian J,Casella G,Zhang Y,Rostami A,Li X

更新日期：2020-01-01 00:00:00

abstract：:Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...

journal_title：International journal of biological sciences

authors： Rao F,Wang T,Li M,Li Z,Hong N,Zhao H,Yan Y,Lu W,Chen T,Wang W,Lim M,Yuan Y,Liu L,Zeng L,Wei Q,Guan G,Li C,Hong Y

更新日期：2011-04-15 00:00:00

abstract：:The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

journal_title：International journal of biological sciences

authors： Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

更新日期：2019-07-25 00:00:00

abstract：:Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...

journal_title：International journal of biological sciences

authors： Li H,Zhang X,Qi X,Zhu X,Cheng L

更新日期：2019-01-01 00:00:00