Abstract：
:Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed. These therapeutic responses are temporary and most cases will eventually undergo PCa recurrence and metastasis, or even progress to castration-resistant prostate cancer (CRPC) due to persistent development of drug resistance. Prostate cancer stem cells (PCSCs) are a small population of cells, which possess unlimited self-renewal capacities, and can regenerate tumorigenic progenies, and play an essential role in PCa therapy resistance, metastasis and recurrence. Nowadays advanced progresses have been made in understanding of PCSC properties, roles of androgen receptor signaling and ATP-binding cassette sub-family G member 2 (ABCG2), as well as roles of genomic non-coding microRNAs and key signaling pathways, which have led to the development of novel therapies which are active against chemoresistant PCa and CRPC. Based on these progresses, this review is dedicated to address mechanisms underlying PCa chemoresistance, unveil crosstalks among pivotal signaling pathways, explore novel biotherapeutic agents, and elaborate functional properties and specific roles of chemoresistant PCSCs, which may act as a promising target for novel therapies against chemoresistant PCa.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Zhang W,Meng Y,Liu N,Wen XF,Yang Tdoi
10.7150/ijbs.11439subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1160-70issue
10issn
1449-2288pii
ijbsv11p1160journal_volume
11pub_type
杂志文章,评审abstract：BACKGROUND:To evaluate the promoter methylation status of RECK gene and mRNA expression in patients with hepatocellular carcinoma (HCC). METHODS:We analyzed RECK methylation by MSP, and RECK mRNA by real-time PCR in 74 HCC. The liver cell lines (7721, Chang and Hep-G2) were treated with 5-Aza-CdR and TSA. RESULTS:REC...
journal_title：International journal of biological sciences
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doi：10.7150/ijbs.4038
更新日期：2012-01-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FLSs). FLSs were isol...
journal_title：International journal of biological sciences
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更新日期：2017-02-25 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：2010-07-04 00:00:00
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更新日期：2013-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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更新日期：2014-04-26 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-06-14 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.5453
更新日期：2013-01-01 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.13525
更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.7150/ijbs.33710
更新日期：2019-05-07 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
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更新日期：2017-07-18 00:00:00
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更新日期：2013-05-15 00:00:00
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更新日期：2009-10-28 00:00:00
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更新日期：2016-06-24 00:00:00
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更新日期：2012-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：2019-06-02 00:00:00
