Abstract：
:Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer. In vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells apoptosis, inhibited the activities of PI3K, Akt, PKA, mTOR and PTEN, and decreased the activation of NF-κB and expression of NF-κB-regulated products. In vivo application of the combination therapy induced significant enhancement of tumor cell apoptosis, reductions in tumor volume, and inhibited activation of mTOR and PTEN. In conclusion, evodiamine can augment the therapeutic effect of gemcitabine in pancreatic cancer through direct or indirect negative regulation of the PI3K/Akt pathway.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Wei WT,Chen H,Wang ZH,Ni ZL,Liu HB,Tong HF,Guo HC,Liu DL,Lin SZdoi
10.7150/ijbs.8.1subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1-14issue
1issn
1449-2288journal_volume
8pub_type
杂志文章abstract：:Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple organs and are characterized by hyperglycaemia. Currently, stable and effective treatments for obesity and type 2 diabetes mellitus are not available. Therefore, the mechanisms leading to obesity and diabetes and more effectiv...
journal_title：International journal of biological sciences
pub_type： 杂志文章,评审
doi：10.7150/ijbs.27173
更新日期：2018-08-06 00:00:00
abstract：:Germ cells produce sperm and eggs for reproduction and fertility. The Asian seabass (Lates calcarifer), a protandrous marine fish, undergoes male-female sex reversal and thus offers an excellent model to study the role of germ cells in sex differentiation and sex reversal. Here we report the cloning and expression of ...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.6797
更新日期：2014-02-06 00:00:00
abstract：:Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer,...
journal_title：International journal of biological sciences
pub_type： 杂志文章,评审
doi：10.7150/ijbs.33710
更新日期：2019-05-07 00:00:00
abstract：:Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.42257
更新日期：2020-02-10 00:00:00
abstract：: Objectives: Skeletal development is a complex process. Little is known about the different response of limb or spine growth plate chondrocytes (LGP or SGP) to the estrogen level and the role of estrogen receptor (ER) during postnatal stage. Methods...
journal_title：International journal of biological sciences
pub_type： 杂志文章
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更新日期：2017-01-11 00:00:00
abstract：:Gene silencing techniques are widely used to control gene expression and have potential for RNAi-based therapeutics. In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter. ...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.13011
更新日期：2015-09-03 00:00:00
abstract：:Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...
journal_title：International journal of biological sciences
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abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.6996
更新日期：2013-09-23 00:00:00
abstract：:Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.7.426
更新日期：2011-04-15 00:00:00
abstract：:Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the A...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.38415
更新日期：2020-02-10 00:00:00
abstract：:Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.8.118
更新日期：2012-01-01 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章,评审
doi：10.7150/ijbs.7.536
更新日期：2011-04-27 00:00:00
abstract：:Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide. Glycosphingolipids (GSLs) are involved in virus infection by regulating various steps of viral-host interaction. However, the distinct role of GSLs during DENV infection remains unclear. In this study, we used mouse melano...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.15641
更新日期：2016-05-25 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.12815
更新日期：2016-02-12 00:00:00
abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.23165
更新日期：2018-01-01 00:00:00
abstract：:Triple-negative breast cancer (TNBC) is a tumor subtype with aggressive behavior and poor clinical outcome for lacking effective therapies. Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.16874
更新日期：2016-12-07 00:00:00
abstract：:β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in C2C12 myoblasts. This effect is partly due to the enhanced stability of p27, r...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.17948
更新日期：2017-10-17 00:00:00
abstract：:Toll-like receptor (TLR) signaling is an emerging pathway in tumor cell invasion and metastasis. Myeloid differentiation protein-2 (MD2) contributes to ligand recognition and activation of TLRs in response to exogenous microbial insults or endogenous agents. We hypothesized that blocking MD2 using a specific inhibitor...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.39098
更新日期：2020-02-17 00:00:00
abstract：:Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-related death. Metastatic disease or the movement of cancer cells from one site to another requires dramatic remodeling of the cytoskeleton. The regulation of cancer cell migration is determined not only by biochemical factors in...
journal_title：International journal of biological sciences
pub_type： 杂志文章,评审
doi：10.7150/ijbs.44943
更新日期：2020-04-27 00:00:00
abstract：:The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global infection, and is seriously threatening human life, especially cancer patients. Thus, we sought to determine the clinical roles of ACE2 (the cell entry receptor of SARS-CoV-2) in ccRCC (clear cell renal cell carcinoma). TCGA, ...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.51969
更新日期：2021-01-01 00:00:00
abstract：:Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the priori knowledge about the physiological, biochemical or functional ...
journal_title：International journal of biological sciences
pub_type： 杂志文章,评审
doi：10.7150/ijbs.3.420
更新日期：2007-10-25 00:00:00
abstract：:Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.9126
更新日期：2014-06-24 00:00:00
abstract：:The gene encoding PDX1 (pancreatic duodenum homeobox 1), the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic beta-cells, clusters with two closely related homeobox genes (Gsh1 and Cdx2/3), all of them belonging to the ParaHox gene family. The ParaHox gen...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.4.48
更新日期：2008-02-06 00:00:00
abstract：:Bluetongue virus (BTV) replicates in lymphoid tissues where infected mononuclear leukocytes secrete proinflammatory and vasoactive mediators that can contribute to bluetongue (BT) pathogenesis. Using the well-characterized IFNAR(-/-) mice animal model, we have now studied the histopathology and dynamics of leukocyte p...
journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.14967
更新日期：2016-11-24 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.5.637
更新日期：2009-10-09 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.7.1273
更新日期：2011-01-01 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.31781
更新日期：2019-11-01 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.33671
更新日期：2019-05-12 00:00:00
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journal_title：International journal of biological sciences
pub_type： 杂志文章
doi：10.7150/ijbs.7495
更新日期：2014-04-25 00:00:00
abstract：:Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...
journal_title：International journal of biological sciences
pub_type： 杂志文章,评审
doi：10.7150/ijbs.7.575
更新日期：2011-01-01 00:00:00
