Vasa identifies germ cells and critical stages of oogenesis in the Asian seabass.

abstract：:MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors. Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. In this study, we rep...

journal_title：International journal of biological sciences

authors： Zhang W,Duan N,Zhang Q,Song T,Li Z,Zhang C,Chen X,Wang K

更新日期：2017-04-10 00:00:00

abstract：:Cardiac metabolic remodeling is recognized as an important hallmark of heart failure (HF), while strategies that target energy metabolism have therapeutic potential in treating HF. Shen-Fu formula (S-F) is a standardized herbal preparation frequently used in clinical practice and is a promising combinatorial therapy f...

journal_title：International journal of biological sciences

authors： Huang Y,Zhang K,Jiang M,Ni J,Chen J,Li L,Deng J,Zhu Y,Mao J,Gao X,Fan G

更新日期：2020-10-16 00:00:00

abstract：:Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn...

journal_title：International journal of biological sciences

authors： Wu JR,Yeh JL,Liou SF,Dai ZK,Wu BN,Hsu JH

更新日期：2016-07-18 00:00:00

abstract：:The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...

journal_title：International journal of biological sciences

authors： Jia S,Zhao L,Tang W,Luo Y

更新日期：2012-01-01 00:00:00

abstract：:Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs). In the current study, we investigated whether NPCs expressing Vascula...

journal_title：International journal of biological sciences

authors： Maurer MH,Thomas C,Bürgers HF,Kuschinsky W

更新日期：2007-12-03 00:00:00

abstract：:Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...

journal_title：International journal of biological sciences

authors： Cao P,Xia Y,He W,Zhang T,Hong L,Zheng P,Shen X,Liang G,Cui R,Zou P

更新日期：2019-06-04 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

journal_title：International journal of biological sciences

authors： Tian J,Casella G,Zhang Y,Rostami A,Li X

更新日期：2020-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FLSs). FLSs were isol...

journal_title：International journal of biological sciences

authors： Fan L,Zong M,Gong R,He D,Li N,Sun LS,Ye Q,Yu S

更新日期：2017-02-25 00:00:00

abstract：:As a systemic syndrome characterized by age-associated degenerative skeletal muscle atrophy, sarcopenia leads to a risk of adverse outcomes in the elderly. Age-related iron accumulation is found in the muscles of sarcopenia animal models and patients, but the role of iron in sarcopenia remains poorly understood. It ha...

journal_title：International journal of biological sciences

authors： Huang Y,Wu B,Shen D,Chen J,Yu Z,Chen C

更新日期：2021-01-01 00:00:00

abstract：:Congenital hypothyroidism (CH) can lead to irreversible central nervous system (CNS) damage. However, the pathogenesis of the developmental brain disorders caused by CH has not been completely elucidated. ARPC5 and CRMP2 are closely associated with neurite outgrowth in brain development. Thus, the aim of the present s...

journal_title：International journal of biological sciences

authors： Liu CR,Miao J,Zhang YL,Liu YM,Yu BG

更新日期：2013-01-01 00:00:00

abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

journal_title：International journal of biological sciences

authors： Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

更新日期：2018-01-01 00:00:00

abstract：:Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96). In the present study we demonstrate the sulfation of a salivary secretory...

journal_title：International journal of biological sciences

authors： Kasinathan C,Gandhi N,Ramaprasad P,Sundaram P,Ramasubbu N

更新日期：2007-03-02 00:00:00

abstract：:Different stimuli often activate the same intracellular signaling molecules but trigger distinct cell responses. We explored whether or not MAPK signaling induced by macrophage colony-stimulating factor (M-CSF), which is responsible for osteoclast proliferation, differs from that induced by receptor activator of NF-κB...

journal_title：International journal of biological sciences

authors： Lee K,Chung YH,Ahn H,Kim H,Rho J,Jeong D

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Increasing evidences suggest that innate immunity is involved in cerebral ischemia-reperfusion (I/R) injury, but the liable innate immune receptors have not been completely elucidated. Here, we explored the role of the nucleotide-binding oligomerization domain (NOD)2, a member of the cytosolic NOD-like recep...

journal_title：International journal of biological sciences

authors： Liu H,Wei X,Kong L,Liu X,Cheng L,Yan S,Zhang X,Chen L

更新日期：2015-03-25 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam ...

journal_title：International journal of biological sciences

authors： Song X,Fischer P,Chen X,Burton C,Wang J

更新日期：2009-10-09 00:00:00

abstract：:N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases...

journal_title：International journal of biological sciences

authors： Zhu ZM,Huo FC,Pei DS

更新日期：2020-04-15 00:00:00

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：:Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

journal_title：International journal of biological sciences

authors： Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

更新日期：2018-11-03 00:00:00

abstract：:The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: ...

journal_title：International journal of biological sciences

authors： Quintero-Gutiérrez AG,González-Rosendo G,Sánchez-Muñoz J,Polo-Pozo J,Rodríguez-Jerez JJ

更新日期：2008-02-18 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivit...

journal_title：International journal of biological sciences

authors： Ma S,Miao H,Luo Y,Sun Y,Tian X,Wang F,You C,Peng S,Tang G,Yang C,Sun W,Li S,Mao Y,Xu J,Xiao Y,Gong Y,Quan H,Xie C

更新日期：2019-03-10 00:00:00

abstract：:The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...

journal_title：International journal of biological sciences

authors： Suzaki Y,Ozawa Y,Kobori H

更新日期：2006-11-01 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

journal_title：International journal of biological sciences

authors： Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

更新日期：2020-02-04 00:00:00

abstract：:D-Xylitol is found in low content as a natural constituent of many fruits and vegetables. It is a five-carbon sugar polyol and has been used as a food additive and sweetening agent to replace sucrose, especially for non-insulin dependent diabetics. It has multiple beneficial health effects, such as the prevention of d...

journal_title：International journal of biological sciences

authors： Chen X,Jiang ZH,Chen S,Qin W

更新日期：2010-12-15 00:00:00

abstract：:Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...

journal_title：International journal of biological sciences

authors： Zhao L,Zhou C,Zhang J,Gao F,Li B,Chuai Y,Liu C,Cai J

更新日期：2011-03-25 00:00:00

abstract：:Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer. In vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells ...

journal_title：International journal of biological sciences

authors： Wei WT,Chen H,Wang ZH,Ni ZL,Liu HB,Tong HF,Guo HC,Liu DL,Lin SZ

更新日期：2012-01-01 00:00:00

abstract：:Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this study, recombinant lentiviral vectors coding for ZIKV structural proteins and truncations (prM-Env, M-En...

journal_title：International journal of biological sciences

authors： Liu J,Li Q,Li X,Qiu Z,Li A,Liang W,Chen H,Cai X,Chen X,Duan X,Li J,Wu W,Xu M,Mao Y,Chen H,Li J,Gu W,Li H

更新日期：2018-06-08 00:00:00

abstract：:Mitochondrial function is of particular importance in brain because of its high demand for energy (ATP) and efficient removal of reactive oxygen species (ROS). We developed rat mitochondrion-neuron focused microarray (rMNChip) and integrated bioinformatics tools for rapid identification of differential pathways in bra...

journal_title：International journal of biological sciences

authors： Su YA,Zhang Q,Su DM,Tang MX

更新日期：2011-03-29 00:00:00