Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain.

abstract：:Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

journal_title：International journal of biological sciences

authors： Yang N,Shen HM

更新日期：2020-03-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specifi...

journal_title：International journal of biological sciences

authors： Yang G,Yang X

更新日期：2010-01-01 00:00:00

abstract：:MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors. Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. In this study, we rep...

journal_title：International journal of biological sciences

authors： Zhang W,Duan N,Zhang Q,Song T,Li Z,Zhang C,Chen X,Wang K

更新日期：2017-04-10 00:00:00

abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

journal_title：International journal of biological sciences

authors： Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

更新日期：2018-01-01 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. Th...

journal_title：International journal of biological sciences

authors： Guo Z,Qiu Y

更新日期：2011-01-01 00:00:00

abstract：:Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer. In vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells ...

journal_title：International journal of biological sciences

authors： Wei WT,Chen H,Wang ZH,Ni ZL,Liu HB,Tong HF,Guo HC,Liu DL,Lin SZ

更新日期：2012-01-01 00:00:00

abstract：:Melatonin is present in mammalian follicular fluid and plays an important role in regulating steroidogenesis in follicular cells. In this study, we report the effect of melatonin on steroidogenesis in the theca interna (TI) in small bovine follicles and theca cells (TCs) cultured in vitro. Treatment with melatonin sig...

journal_title：International journal of biological sciences

authors： Wang X,Meng K,He Y,Wang H,Zhang Y,Quan F

更新日期：2019-01-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a key process in EGFR-TKI resistance but the detailed mechanism is largely unknown. We aim to evaluate the role of interleukin-6 (IL-6) and insulin-like growth factor-1 receptor (IGR-1R) in EMT in non-small cell lung cancer (NSCLC). We used IL-6 to induce EMT in EGFR-TKI s...

journal_title：International journal of biological sciences

authors： Zheng X,Lu G,Yao Y,Gu W

更新日期：2019-07-20 00:00:00

abstract：:Despite years of research into bone formation, the mechanisms by which transcription factors specify growth plate development and trabecular bone formation remain unclear and the role of hypertrophic chondrocytes in trabeculae morphogenesis is controversial. To study the role of Core binding factor beta (Cbfβ) in post...

journal_title：International journal of biological sciences

authors： Wu M,Li YP,Zhu G,Lu Y,Wang Y,Jules J,McConnell M,Serra R,Shao JZ,Chen W

更新日期：2014-07-29 00:00:00

abstract：:Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...

journal_title：International journal of biological sciences

authors： Hussain G,Wang J,Rasul A,Anwar H,Qasim M,Zafar S,Aziz N,Razzaq A,Hussain R,de Aguilar JG,Sun T

更新日期：2020-01-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam ...

journal_title：International journal of biological sciences

authors： Song X,Fischer P,Chen X,Burton C,Wang J

更新日期：2009-10-09 00:00:00

abstract：:The gene encoding PDX1 (pancreatic duodenum homeobox 1), the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic beta-cells, clusters with two closely related homeobox genes (Gsh1 and Cdx2/3), all of them belonging to the ParaHox gene family. The ParaHox gen...

journal_title：International journal of biological sciences

authors： Rosanas-Urgell A,Garcia-Fernàndez J,Marfany G

更新日期：2008-02-06 00:00:00

abstract：:Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...

journal_title：International journal of biological sciences

authors： Yao H,Teng Y,Sun Q,Xu J,Chen YT,Hou N,Cheng X,Yang X,Chen ZN

更新日期：2013-12-13 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to eva...

journal_title：International journal of biological sciences

authors： Wang L,Wei W,Xiao Q,Yang H,Ci X

更新日期：2019-01-29 00:00:00

abstract：:Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

journal_title：International journal of biological sciences

authors： Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

更新日期：2018-11-03 00:00:00

abstract：:Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect neuronal cells against oxidative stress in neurodegenerative diseases. The present study was designed to examine whether CoQ10 was capable of protecting astrocytes from reactive oxygen species (ROS) mediated damage. For this purpose, ultraviole...

journal_title：International journal of biological sciences

authors： Jing L,He MT,Chang Y,Mehta SL,He QP,Zhang JZ,Li PA

更新日期：2015-01-01 00:00:00

abstract：:Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

journal_title：International journal of biological sciences

authors： Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

更新日期：2019-11-01 00:00:00

abstract：:Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...

journal_title：International journal of biological sciences

authors： Wang H,Shi L,Liang T,Wang B,Wu W,Su G,Wei J,Li P,Huang R

更新日期：2017-03-11 00:00:00

abstract：:Toll-like receptor (TLR) signaling is an emerging pathway in tumor cell invasion and metastasis. Myeloid differentiation protein-2 (MD2) contributes to ligand recognition and activation of TLRs in response to exogenous microbial insults or endogenous agents. We hypothesized that blocking MD2 using a specific inhibitor...

journal_title：International journal of biological sciences

authors： Rajamanickam V,Yan T,Xu S,Hui J,Xu X,Ren L,Liu Z,Liang G,Wang O,Wang Y

更新日期：2020-02-17 00:00:00

abstract：:CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

journal_title：International journal of biological sciences

authors： Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

更新日期：2019-09-07 00:00:00

abstract：:The effects of hormonal and dietary stimuli on hepatic glucose and lipid homeostasis include regulation of gene expression. Berberine, an effective compound in certain Chinese medicinal herbs, has been reported to lower plasma glucose and lipid levels in diabetic and hypercholesterolemic patients. We hypothesized that...

journal_title：International journal of biological sciences

authors： Ge Y,Zhang Y,Li R,Chen W,Li Y,Chen G

更新日期：2011-01-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...

journal_title：International journal of biological sciences

authors： Pisa D,Alonso R,Carrasco L

更新日期：2020-02-10 00:00:00

abstract：:The objective of this study was to study the effect of diabetic hyperglycemia on astrocytes after forebrain ischemia. Streptozotocin (STZ)-injected hyperglycemic and vehicle-injected normoglycemic rats were subjected to 15 minutes of forebrain ischemia. The brains were harvested in sham-operated controls and in animal...

journal_title：International journal of biological sciences

authors： Jing L,Mai L,Zhang JZ,Wang JG,Chang Y,Dong JD,Guo FY,Li PA

更新日期：2013-09-25 00:00:00

abstract：:Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

journal_title：International journal of biological sciences

authors： Zhang Q,Dong J,Yu Z

更新日期：2020-08-13 00:00:00

abstract：:Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...

journal_title：International journal of biological sciences

authors： Li X,Kazgan N

更新日期：2011-01-01 00:00:00

abstract：:Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction ...

journal_title：International journal of biological sciences

authors： Lin X,Zhang Y,Liu L,McKeehan WL,Shen Y,Song S,Wang F

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. METHODS:A total of 144 subjects were divided into 4 groups: normoglycemia (ND; 46 cases), mild gestational hyperglycemia (MGH; 30 cases), gestational diab...

journal_title：International journal of biological sciences

authors： Moreli JB,Santos JH,Lorenzon-Ojea AR,Corrêa-Silva S,Fortunato RS,Rocha CR,Rudge MV,Damasceno DC,Bevilacqua E,Calderon IM

更新日期：2016-02-12 00:00:00

abstract：:Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...

journal_title：International journal of biological sciences

authors： Zhao L,Zhou C,Zhang J,Gao F,Li B,Chuai Y,Liu C,Cai J

更新日期：2011-03-25 00:00:00

abstract：:In China, Bemisia tabaci Q (commonly known as biotype Q) has rapidly displaced B (commonly known as biotype B) in the past 6 years. The mechanisms underlying such phenomenon have been studied extensively in recent years; however, we have not come to a definitive conclusion yet. In the present study, the differences in...

journal_title：International journal of biological sciences

authors： Liu B,Yan F,Chu D,Pan H,Jiao X,Xie W,Wu Q,Wang S,Xu B,Zhou X,Zhang Y

更新日期：2012-01-01 00:00:00