Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes.

abstract：:Emerging evidence has indicated that abnormal microRNAs (miRNAs) participated in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Better understanding the association between miRNAs and HCC may contribute to discover novel therapeutic approaches for diagnosis and treatments. In the current study...

journal_title：International journal of biological sciences

authors： Wang L,Sun L,Wang Y,Yao B,Liu R,Chen T,Tu K,Liu Q,Liu Z

更新日期：2019-06-02 00:00:00

abstract：:Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

journal_title：International journal of biological sciences

authors： Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

更新日期：2018-07-27 00:00:00

abstract：:The development of alternative energy technology is critically important because of the rising prices of crude oil, security issues regarding the oil supply, and environmental issues such as global warming and air pollution. Bioconversion of biomass has significant advantages over other alternative energy strategies b...

journal_title：International journal of biological sciences

authors： Dashtban M,Schraft H,Qin W

更新日期：2009-09-04 00:00:00

abstract：:Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

journal_title：International journal of biological sciences

authors： Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

更新日期：2018-06-03 00:00:00

abstract：:RNA interference has been described as a powerful genetic tool for gene functional analysis and a promising approach for pest management. However, RNAi efficiency varies significantly among insect species due to distinct RNAi machineries. Lepidopteran insects include a large number of pests as well as model insects, s...

journal_title：International journal of biological sciences

authors： Li Z,Zeng B,Ling L,Xu J,You L,Aslam AF,Tan A,Huang Y

更新日期：2015-01-05 00:00:00

abstract：:About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

journal_title：International journal of biological sciences

authors： Guan R,Wen X,Liang Y,Xu D,He B,Feng X

更新日期：2019-08-06 00:00:00

abstract：:Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in glioma. Expressions of RRM2 are higher in glioma tissues evidenced by TCGA data, western blot and immunohistoche...

journal_title：International journal of biological sciences

authors： Sun H,Yang B,Zhang H,Song J,Zhang Y,Xing J,Yang Z,Wei C,Xu T,Yu Z,Xu Z,Hou M,Ji M,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others...

journal_title：International journal of biological sciences

authors： Logsdon CD,Lu W

更新日期：2016-01-28 00:00:00

abstract：:Two assumptions underlie current models of the geographical ranges of perennial plant species: 1. current ranges are in equilibrium with the prevailing climate, and 2. changes are attributable to changes in macroclimatic factors, including tolerance of winter cold, the duration of the growing season, and water stress ...

journal_title：International journal of biological sciences

authors： Kramer K,Bijlsma RJ,Hickler T,Thuiller W

更新日期：2012-01-01 00:00:00

abstract：:To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...

journal_title：International journal of biological sciences

authors： Dai J,Li Y,Zhou H,Chen J,Chen M,Xiao Z

更新日期：2013-11-21 00:00:00

abstract：:Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...

journal_title：International journal of biological sciences

authors： Hussain G,Wang J,Rasul A,Anwar H,Qasim M,Zafar S,Aziz N,Razzaq A,Hussain R,de Aguilar JG,Sun T

更新日期：2020-01-01 00:00:00

abstract：:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

journal_title：International journal of biological sciences

authors： Tian J,Casella G,Zhang Y,Rostami A,Li X

更新日期：2020-01-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam ...

journal_title：International journal of biological sciences

authors： Song X,Fischer P,Chen X,Burton C,Wang J

更新日期：2009-10-09 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:The standard of care for patients who suffer from non-organ confined prostate cancer (CaP) is androgen deprivation therapy (ADT). ADT exploits the reliance of CaP cells on androgen receptor (AR) signaling throughout CaP progression from androgen-stimulated (AS) to castration-recurrent (CR) disease. AR is a member of t...

journal_title：International journal of biological sciences

authors： Heemers HV

更新日期：2014-06-01 00:00:00

abstract：:BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues....

journal_title：International journal of biological sciences

authors： Baek HJ,Kim SE,Choi EK,Kim JK,Shin DH,Park EJ,Kim TH,Kim JY,Kim KG,Deng CX,Kim SS

更新日期：2018-10-03 00:00:00

abstract：:Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs). In the current study, we investigated whether NPCs expressing Vascula...

journal_title：International journal of biological sciences

authors： Maurer MH,Thomas C,Bürgers HF,Kuschinsky W

更新日期：2007-12-03 00:00:00

abstract：:Different stimuli often activate the same intracellular signaling molecules but trigger distinct cell responses. We explored whether or not MAPK signaling induced by macrophage colony-stimulating factor (M-CSF), which is responsible for osteoclast proliferation, differs from that induced by receptor activator of NF-κB...

journal_title：International journal of biological sciences

authors： Lee K,Chung YH,Ahn H,Kim H,Rho J,Jeong D

更新日期：2016-01-01 00:00:00

abstract：:By introduction of Oct4, Sox2, Klf4 and cMyc, human adult somatic cells can be reprogrammed into embryonic stem cell capable of pluripotent differentiation. In several lines of human endometrial polyp- and cervical polyp-mesenchymal stem cells (EPMSCs and CPMSC), we showed introduction of the four transcription factor...

journal_title：International journal of biological sciences

authors： Ding DC,Chu TY,Liu HW

更新日期：2018-09-07 00:00:00

abstract：:Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune respon...

journal_title：International journal of biological sciences

authors： Huang WZ,Hu WH,Wang Y,Chen J,Hu ZQ,Zhou J,Liu L,Qiu W,Tang FZ,Zhang SC,Ouyang Y,Ye YN,Xu GQ,Long JH,Zeng Z

更新日期：2019-05-20 00:00:00

abstract：:Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell ...

journal_title：International journal of biological sciences

authors： López-Navarrete G,Ramos-Martínez E,Suárez-Álvarez K,Aguirre-García J,Ledezma-Soto Y,León-Cabrera S,Gudiño-Zayas M,Guzmán C,Gutiérrez-Reyes G,Hernández-Ruíz J,Camacho-Arroyo I,Robles-Díaz G,Kershenobich D,Terrazas LI,Escobedo

更新日期：2011-01-01 00:00:00

abstract：:Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this study, recombinant lentiviral vectors coding for ZIKV structural proteins and truncations (prM-Env, M-En...

journal_title：International journal of biological sciences

authors： Liu J,Li Q,Li X,Qiu Z,Li A,Liang W,Chen H,Cai X,Chen X,Duan X,Li J,Wu W,Xu M,Mao Y,Chen H,Li J,Gu W,Li H

更新日期：2018-06-08 00:00:00

abstract：:The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...

journal_title：International journal of biological sciences

authors： Jia S,Zhao L,Tang W,Luo Y

更新日期：2012-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) wild-type is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs). In this study, we assessed whether the combination of bisdemethoxycurcumin (BDMC) and icotinib could surmount primary EGFR-TKI resistance in NSCLC cells and inves...

journal_title：International journal of biological sciences

authors： Xiang M,Jiang HG,Shu Y,Chen YJ,Jin J,Zhu YM,Li MY,Wu JN,Li J

更新日期：2020-03-05 00:00:00

abstract：:After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...

journal_title：International journal of biological sciences

authors： Zheng B,Zhou Y,Zhang H,Yang G,Hong Z,Han D,Wang Q,He Z,Liu Y,Wu F,Zhang X,Tong S,Xu H,Xiao J

更新日期：2017-11-27 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases....

journal_title：International journal of biological sciences

authors： Wang H,Lafdil F,Kong X,Gao B

更新日期：2011-04-27 00:00:00

abstract：:Osteosarcoma (OS) is considered the most common type of primary malignant bone tumor, which has an urgent need for more effective treatment. Recently, chitinase 3 like 1 (Chi3L1) expression has been found in a variety of cancer cells. However it is not known whether Chi3L1 regulates the STAT3 pathway in OS cells. Here...

journal_title：International journal of biological sciences

authors： Park KR,Yun HM,Hong JT

更新日期：2020-01-01 00:00:00

abstract：:The terminal loop region of primary miRNA transcripts is an important determinant controlling miRNA function in human, animals and plants. However, the effects of polymorphisms in loop region of miRNA precusors on phenotypic variation have not been reported, especially on agronomic traits in rice. From rice japonica v...

journal_title：International journal of biological sciences

authors： Wang C,Ye J,Tang W,Liu Z,Zhu C,Wang M,Wan J

更新日期：2013-06-16 00:00:00

abstract：:Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...

journal_title：International journal of biological sciences

authors： Wang H,Shi L,Liang T,Wang B,Wu W,Su G,Wei J,Li P,Huang R

更新日期：2017-03-11 00:00:00