Abstract:
:Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune responses. However, due to the complexity of the immune system, the dynamic changes in the number of cells during the peripheral tissue (e.g. skin and mucosa) immune response induced by DCs are still poorly understood. Therefore, this study simulated dynamic number changes of DCs and T cells in this process by constructing several ordinary differential equations and setting the initial conditions of the functions and parameters. The results showed that these equations could simulate dynamic numerical changes of DCs and T cells in peripheral tissue and lymph node, which was in accordance with the physiological conditions such as the duration of immune response, the proliferation rates and the motilities of DCs and T cells. This model provided a theoretical reference for studying the immunologic functions of DCs and practical guidance for the clinical DCs-based therapy against immune-related diseases.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Huang WZ,Hu WH,Wang Y,Chen J,Hu ZQ,Zhou J,Liu L,Qiu W,Tang FZ,Zhang SC,Ouyang Y,Ye YN,Xu GQ,Long JH,Zeng Zdoi
10.7150/ijbs.33412subject
Has Abstractpub_date
2019-05-20 00:00:00pages
1396-1403issue
7issn
1449-2288pii
ijbsv15p1396journal_volume
15pub_type
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