Identification and Characterization of Novel Maize Mirnas Involved in Different Genetic Background.

abstract：:Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (c...

journal_title：International journal of biological sciences

authors： Zhang C,Ma L,Niu Y,Wang Z,Xu X,Li Y,Yu Y

更新日期：2020-01-16 00:00:00

abstract：:Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

journal_title：International journal of biological sciences

authors： Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

更新日期：2018-06-03 00:00:00

abstract：:Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform pa...

journal_title：International journal of biological sciences

authors： Verkerk AO,Wilders R,van Borren MM,Tan HL

更新日期：2009-01-01 00:00:00

abstract：:As one of the most ominous malignancies, hepatocellular carcinoma (HCC) is frequently diagnosed at an advanced stage, owing to its aggressive invasion and metastatic spread. Emerging evidence has demonstrated that Rictor, as a unique component of the mTORC2, plays a role in cell migration, as it is dysregulated in var...

journal_title：International journal of biological sciences

authors： Dong X,Feng M,Yang H,Liu H,Guo H,Gao X,Liu Y,Liu R,Zhang N,Chen R,Kong R

更新日期：2020-09-01 00:00:00

abstract：:With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivit...

journal_title：International journal of biological sciences

authors： Ma S,Miao H,Luo Y,Sun Y,Tian X,Wang F,You C,Peng S,Tang G,Yang C,Sun W,Li S,Mao Y,Xu J,Xiao Y,Gong Y,Quan H,Xie C

更新日期：2019-03-10 00:00:00

abstract：:Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...

journal_title：International journal of biological sciences

authors： Li H,Zhang X,Qi X,Zhu X,Cheng L

更新日期：2019-01-01 00:00:00

abstract：:Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A. In this study we aimed to compare both cell lines on applicability in BALs...

journal_title：International journal of biological sciences

authors： van Wenum M,Adam AA,Hakvoort TB,Hendriks EJ,Shevchenko V,van Gulik TM,Chamuleau RA,Hoekstra R

更新日期：2016-06-24 00:00:00

abstract：:About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

journal_title：International journal of biological sciences

authors： Guan R,Wen X,Liang Y,Xu D,He B,Feng X

更新日期：2019-08-06 00:00:00

abstract：:Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

journal_title：International journal of biological sciences

authors： Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

更新日期：2014-03-10 00:00:00

abstract：:Genetic variant T329S in flavin-containing monooxygenase 3 (FMO3) impairs trimethylamine (TMA) metabolism in birds. The TMA metabolism that under complex genetic and dietary regulation, closely linked to cardiovascular disease risk. We determined whether the genetic defects in TMA metabolism may change other metabolic...

journal_title：International journal of biological sciences

authors： Wang J,Long C,Zhang H,Zhang Y,Wang H,Yue H,Wang X,Wu S,Qi G

更新日期：2016-10-25 00:00:00

abstract：:Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the priori knowledge about the physiological, biochemical or functional ...

journal_title：International journal of biological sciences

authors： Zhu M,Zhao S

更新日期：2007-10-25 00:00:00

abstract：: Objectives: Skeletal development is a complex process. Little is known about the different response of limb or spine growth plate chondrocytes (LGP or SGP) to the estrogen level and the role of estrogen receptor (ER) during postnatal stage. Methods...

journal_title：International journal of biological sciences

authors： Shi S,Zheng S,Li XF,Liu ZD

更新日期：2017-01-11 00:00:00

abstract：:Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed. These therapeutic responses are t...

journal_title：International journal of biological sciences

authors： Zhang W,Meng Y,Liu N,Wen XF,Yang T

更新日期：2015-08-01 00:00:00

abstract：:A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evident...

journal_title：International journal of biological sciences

authors： Langeland JA,Holland LZ,Chastain RA,Holland ND

更新日期：2006-01-01 00:00:00

abstract：:RNA interference has been described as a powerful genetic tool for gene functional analysis and a promising approach for pest management. However, RNAi efficiency varies significantly among insect species due to distinct RNAi machineries. Lepidopteran insects include a large number of pests as well as model insects, s...

journal_title：International journal of biological sciences

authors： Li Z,Zeng B,Ling L,Xu J,You L,Aslam AF,Tan A,Huang Y

更新日期：2015-01-05 00:00:00

abstract：:Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...

journal_title：International journal of biological sciences

authors： Zhao W,Ma L,Cai C,Gong X

更新日期：2019-06-02 00:00:00

abstract：:Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular cargos, including long noncoding RNAs (lncRNAs). Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a well-known lncRNA associated with cancer angiogenesis and metastasis. However, the presence of MALAT1 in exoso...

journal_title：International journal of biological sciences

authors： Qiu JJ,Lin XJ,Tang XY,Zheng TT,Lin YY,Hua KQ

更新日期：2018-11-01 00:00:00

abstract：:Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the pathogenesis of S...

journal_title：International journal of biological sciences

authors： Peng Q,Xu H,Xiao M,Wang L

更新日期：2020-09-19 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: ...

journal_title：International journal of biological sciences

authors： Quintero-Gutiérrez AG,González-Rosendo G,Sánchez-Muñoz J,Polo-Pozo J,Rodríguez-Jerez JJ

更新日期：2008-02-18 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) wild-type is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs). In this study, we assessed whether the combination of bisdemethoxycurcumin (BDMC) and icotinib could surmount primary EGFR-TKI resistance in NSCLC cells and inves...

journal_title：International journal of biological sciences

authors： Xiang M,Jiang HG,Shu Y,Chen YJ,Jin J,Zhu YM,Li MY,Wu JN,Li J

更新日期：2020-03-05 00:00:00

abstract：:We collected clinical data from 308 prostate cancer (PCa) patients to investigate the clinical characteristics and independent risk factors of bone metastasis (BM) and to establish a prediction model for BM of PCa and determine the necessity of bone scans. Univariate and multivariate analyses were performed based on a...

journal_title：International journal of biological sciences

authors： Chen S,Wang L,Qian K,Jiang W,Deng H,Zhou Q,Wang G,Liu X,Wu CL,Xiao Y,Wang X

更新日期：2019-01-01 00:00:00

abstract：:Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...

journal_title：International journal of biological sciences

authors： Zhao L,Zhou C,Zhang J,Gao F,Li B,Chuai Y,Liu C,Cai J

更新日期：2011-03-25 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specifi...

journal_title：International journal of biological sciences

authors： Yang G,Yang X

更新日期：2010-01-01 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. Th...

journal_title：International journal of biological sciences

authors： Guo Z,Qiu Y

更新日期：2011-01-01 00:00:00

abstract：:Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...

journal_title：International journal of biological sciences

authors： Wu YL,Ding YP,Tanaka Y,Shen LW,Wei CH,Minato N,Zhang W

更新日期：2014-01-10 00:00:00

abstract：:Hyperglycemia is known to exacerbate neuronal death resulted from cerebral ischemia. The mechanisms are not fully understood. The mammalian target of rapamycin (mTOR) pathway regulates cell growth, division and apoptosis. Recent studies suggest that activation of mTOR may mediate ischemic brain damage. The objective o...

journal_title：International journal of biological sciences

authors： Hei C,Liu P,Yang X,Niu J,Li PA

更新日期：2017-07-07 00:00:00