Abstract:
:Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elucidated. Based on analysis of GEO database and immunohistochemical detection of patient-derived pancreatic cancer tissues, we found that SMARCAD1 is more highly expressed in pancreatic cancer tissues and that its expression level negatively correlates with patients' survival time. With further investigation, it shows that SMARCAD1 promotes the proliferation, migration, invasion of pancreatic cancer cells. Mechanistically, we first demonstrate that SMARCAD1 induces EMT via activating Wnt/β-catenin signaling pathway in pancreatic cancer. Our results provide the role and potential mechanism of SMARCAD1 in pancreatic cancer, which may prove useful marker for diagnostic or therapeutic applications of PC disease.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Liu F,Xia Z,Zhang M,Ding J,Feng Y,Wu J,Dong Y,Gao W,Han Z,Liu Y,Yao Y,Li Ddoi
10.7150/ijbs.29562subject
Has Abstractpub_date
2019-01-01 00:00:00pages
636-646issue
3issn
1449-2288pii
ijbsv15p0636journal_volume
15pub_type
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