A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment.

abstract：:Foxp3⁺ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3(+) subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENK...

journal_title：International journal of biological sciences

authors： Peng RJ,Huang ZF,Zhang YL,Yuan ZY,Xia Y,Jiang WQ,Zeng YX,Li J

更新日期：2011-01-01 00:00:00

abstract：:Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma and play an essential role in tumor progression and metastasis in a variety of malignancies, including gastric cancer. However, the effects of CAFs on gastr...

journal_title：International journal of biological sciences

authors： Xu G,Zhang B,Ye J,Cao S,Shi J,Zhao Y,Wang Y,Sang J,Yao Y,Guan W,Tao J,Feng M,Zhang W

更新日期：2019-08-22 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) occurs with the highest frequency in China, especially in the high-risk Northern Chinese. Recent studies have reported that SLC22A3 is significantly downregulated in non-tumor (NT) esophageal tissues from familial ESCC patients compared with those from sporadic ESCC. However, ...

journal_title：International journal of biological sciences

authors： Xiong JX,Wang YS,Sheng J,Xiang D,Huang TX,Tan BB,Zeng CM,Li HH,Yang J,Meltzer SJ,Mori Y,Qin YR,Guan XY,Fu L

更新日期：2018-09-07 00:00:00

abstract：:After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...

journal_title：International journal of biological sciences

authors： Zheng B,Zhou Y,Zhang H,Yang G,Hong Z,Han D,Wang Q,He Z,Liu Y,Wu F,Zhang X,Tong S,Xu H,Xiao J

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...

journal_title：International journal of biological sciences

authors： Qu W,Xiao J,Zhang H,Chen Q,Wang Z,Shi H,Gong L,Chen J,Liu Y,Cao R,Lv J

更新日期：2013-08-14 00:00:00

abstract：:Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

journal_title：International journal of biological sciences

authors： Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

更新日期：2018-04-05 00:00:00

abstract：:The standard of care for patients who suffer from non-organ confined prostate cancer (CaP) is androgen deprivation therapy (ADT). ADT exploits the reliance of CaP cells on androgen receptor (AR) signaling throughout CaP progression from androgen-stimulated (AS) to castration-recurrent (CR) disease. AR is a member of t...

journal_title：International journal of biological sciences

authors： Heemers HV

更新日期：2014-06-01 00:00:00

abstract：:Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

journal_title：International journal of biological sciences

authors： Yang N,Shen HM

更新日期：2020-03-15 00:00:00

abstract：:Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human...

journal_title：International journal of biological sciences

authors： Huang A,Dong J,Li S,Wang C,Ding H,Li H,Su X,Ge X,Sun L,Bai C,Shen X,Fang T,Li J,Shao N

更新日期：2015-06-11 00:00:00

abstract：:The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...

journal_title：International journal of biological sciences

authors： Suzaki Y,Ozawa Y,Kobori H

更新日期：2006-11-01 00:00:00

abstract：:It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...

journal_title：International journal of biological sciences

authors： Cai H,Li X,Li J,Liang Q,Zheng W,Guan Q,Guo Z,Wang X

更新日期：2018-05-22 00:00:00

abstract：:Pork quality is an economically important trait and one of the main selection criteria for breeding in the swine industry. In this genome-wide association study (GWAS), 455 pigs from a porcine Large White × Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip, and phenotyped for intram...

journal_title：International journal of biological sciences

authors： Luo W,Cheng D,Chen S,Wang L,Li Y,Ma X,Song X,Liu X,Li W,Liang J,Yan H,Zhao K,Wang C,Wang L,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...

journal_title：International journal of biological sciences

authors： Dai J,Li Y,Zhou H,Chen J,Chen M,Xiao Z

更新日期：2013-11-21 00:00:00

abstract：:Germ cells produce sperm and eggs for reproduction and fertility. The Asian seabass (Lates calcarifer), a protandrous marine fish, undergoes male-female sex reversal and thus offers an excellent model to study the role of germ cells in sex differentiation and sex reversal. Here we report the cloning and expression of ...

journal_title：International journal of biological sciences

authors： Xu H,Lim M,Dwarakanath M,Hong Y

更新日期：2014-02-06 00:00:00

abstract：:TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral sclerosis (ALS) that is characterized by progressive degeneration of motor neurons. To better understand the correlation of A...

journal_title：International journal of biological sciences

authors： Huang C,Xia PY,Zhou H

更新日期：2010-07-04 00:00:00

abstract：:Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...

journal_title：International journal of biological sciences

authors： Wang H,Shi L,Liang T,Wang B,Wu W,Su G,Wei J,Li P,Huang R

更新日期：2017-03-11 00:00:00

abstract：:Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

journal_title：International journal of biological sciences

authors： Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

更新日期：2014-03-10 00:00:00

abstract：:Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

journal_title：International journal of biological sciences

authors： Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

更新日期：2018-07-27 00:00:00

abstract：:The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...

journal_title：International journal of biological sciences

authors： Jia S,Zhao L,Tang W,Luo Y

更新日期：2012-01-01 00:00:00

abstract：:Non-coding RNAs (ncRNAs) are transcribed from genome but not translated into proteins. Many ncRNAs are key regulators of plants growth and development, metabolism and stress tolerance. In order to make the web-based ncRNA resources for plant science research be more easily accessible and understandable, we made a comp...

journal_title：International journal of biological sciences

authors： Liao P,Li S,Cui X,Zheng Y

更新日期：2018-05-22 00:00:00

abstract：:Type 2 diabetes mellitus is characterized by insulin resistance. However, the complete molecular mechanism remains unclear. In this study, zebrafish were fed a long-term high-fat diet to induce type 2 diabetes, which resulted in a higher body weight, body mass index, more lipid vacuoles in liver, increased insulin tra...

journal_title：International journal of biological sciences

authors： Meng XH,Chen B,Zhang JP

更新日期：2017-07-18 00:00:00

abstract：:Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...

journal_title：International journal of biological sciences

authors： Pisa D,Alonso R,Carrasco L

更新日期：2020-02-10 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others...

journal_title：International journal of biological sciences

authors： Logsdon CD,Lu W

更新日期：2016-01-28 00:00:00

abstract：:Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligome...

journal_title：International journal of biological sciences

authors： Li T,Liu J,Cai H,Wang B,Feng Y,Liu J

更新日期：2018-04-30 00:00:00

abstract：:Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...

journal_title：International journal of biological sciences

authors： Xiao Q,Xia JH,Zhang XJ,Li Z,Wang Y,Zhou L,Gui JF

更新日期：2014-06-24 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Ferroptosis, an iron-dependent form of regulated cell death, can be induced by sorafenib. However, the prognostic value of ferroptosis-related genes in HCC remains to be further elucidated. In this stud...

journal_title：International journal of biological sciences

authors： Liang JY,Wang DS,Lin HC,Chen XX,Yang H,Zheng Y,Li YH

更新日期：2020-07-06 00:00:00

abstract：:The terminal loop region of primary miRNA transcripts is an important determinant controlling miRNA function in human, animals and plants. However, the effects of polymorphisms in loop region of miRNA precusors on phenotypic variation have not been reported, especially on agronomic traits in rice. From rice japonica v...

journal_title：International journal of biological sciences

authors： Wang C,Ye J,Tang W,Liu Z,Zhu C,Wang M,Wan J

更新日期：2013-06-16 00:00:00

abstract：:About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

journal_title：International journal of biological sciences

authors： Guan R,Wen X,Liang Y,Xu D,He B,Feng X

更新日期：2019-08-06 00:00:00

abstract：:Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and ...

journal_title：International journal of biological sciences

authors： Wang Y,Wang J,Deng Z,Jin J,Jiang H,Meng J,Xu H,Zhao J,Sun G,Qian H

更新日期：2017-09-05 00:00:00