Abstract:
:Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs. The HepG2-derived VASN containing exosomes promote migration of recipient HUVECs cells. Our results identify a novel pathway by which a functional protein expressed in tumor cells affects the biological fate of endothelial cells via exosomes.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Huang A,Dong J,Li S,Wang C,Ding H,Li H,Su X,Ge X,Sun L,Bai C,Shen X,Fang T,Li J,Shao Ndoi
10.7150/ijbs.11943subject
Has Abstractpub_date
2015-06-11 00:00:00pages
961-9issue
8issn
1449-2288pii
ijbsv11p0961journal_volume
11pub_type
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