Abstract:
:Pork quality is an economically important trait and one of the main selection criteria for breeding in the swine industry. In this genome-wide association study (GWAS), 455 pigs from a porcine Large White × Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip, and phenotyped for intramuscular fat content (IMF), marbling, moisture, color L*, color a*, color b* and color score in the longissimus muscle (LM). Association tests between each trait and the SNPs were performed via the Genome Wide Rapid Association using the Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approach. From the Ensembl porcine database, SNP annotation was implemented using Sus scrofa Build 9. A total of 45 SNPs showed significant association with one or multiple meat quality traits. Of the 45 SNPs, 36 were located on SSC12. These significantly associated SNPs aligned to or were in close approximation to previously reported quantitative trait loci (QTL) and some were located within introns of previously reported candidate genes. Two haplotype blocks ASGA0100525-ASGA0055225-ALGA0067099-MARC0004712-DIAS0000861, and ASGA0085522-H3GA0056170 were detected in the significant region. The first block contained the genes MYH1, MYH2 and MYH4. A SNP (ASGA0094812) within an intron of the USP43 gene was significantly associated with five meat quality traits. The present results effectively narrowed down the associated regions compared to previous QTL studies and revealed haplotypes and candidate genes on SSC12 for meat quality traits in pigs.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Luo W,Cheng D,Chen S,Wang L,Li Y,Ma X,Song X,Liu X,Li W,Liang J,Yan H,Zhao K,Wang C,Wang L,Zhang Ldoi
10.7150/ijbs.3614subject
Has Abstractpub_date
2012-01-01 00:00:00pages
580-95issue
4issn
1449-2288pii
ijbsv08p0580journal_volume
8pub_type
杂志文章abstract::Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new therapeutic agents for the treatment of atherosclerosis, yet their precise mechanism responsible for atheroprotection remains unclear. Like apoA-I itself, most of these peptides are capable of stimulating cholesterol efflux from macrophages or foam ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5.637
更新日期:2009-10-09 00:00:00
abstract::Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer. In vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8.1
更新日期:2012-01-01 00:00:00
abstract::Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). The receptors AgOR1 and AgOR2, as well as the binding protein AgOBP1, have been implicated in the recognition of human host odors. ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6.614
更新日期:2010-10-08 00:00:00
abstract::The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors. In 1996, we and others identified a superfamily of "regulator of G-protein signaling" (RGS) proteins that acc...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.1.51
更新日期:2005-01-01 00:00:00
abstract::Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.111
更新日期:2007-02-06 00:00:00
abstract::Mast cells are found abundant at sites of acupoints. Nerve cells share perivascular localization with mast cells. Acupuncture (mechanical stimuli) can activate mast cells to release adenosine triphosphate (ATP) which can activate nerve cells and modulates pain-processing pathways in response to acupuncture. In this pa...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8631
更新日期:2014-04-26 00:00:00
abstract::The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5855
更新日期:2013-05-15 00:00:00
abstract::Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8.118
更新日期:2012-01-01 00:00:00
abstract::Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A. In this study we aimed to compare both cell lines on applicability in BALs...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.15165
更新日期:2016-06-24 00:00:00
abstract::Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies in...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.16150
更新日期:2016-10-17 00:00:00
abstract::With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivit...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.29805
更新日期:2019-03-10 00:00:00
abstract::Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.35653
更新日期:2020-01-01 00:00:00
abstract::Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17508
更新日期:2017-03-11 00:00:00
abstract:BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5711
更新日期:2013-08-14 00:00:00
abstract::Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the priori knowledge about the physiological, biochemical or functional ...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.3.420
更新日期:2007-10-25 00:00:00
abstract::Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.11943
更新日期:2015-06-11 00:00:00
abstract::Gene silencing techniques are widely used to control gene expression and have potential for RNAi-based therapeutics. In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter. ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13011
更新日期:2015-09-03 00:00:00
abstract::Pathological cardiac hypertrophy is the response of heart to various biomechanical and physiopathological stimuli, such as aging, myocardial ischemia and hypertension. However, a long-term exposure to the stress makes heart progress to heart failure. Autophagy is a dynamic self-degradative process necessary for the ma...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.11883
更新日期:2015-04-27 00:00:00
abstract::MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors. Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. In this study, we rep...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.19032
更新日期:2017-04-10 00:00:00
abstract::Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.40535
更新日期:2020-02-04 00:00:00
abstract::About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.35743
更新日期:2019-08-06 00:00:00
abstract::Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.45498
更新日期:2020-03-15 00:00:00
abstract::Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.34211
更新日期:2019-06-02 00:00:00
abstract::Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in glioma. Expressions of RRM2 are higher in glioma tissues evidenced by TCGA data, western blot and immunohistoche...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.30114
更新日期:2019-01-01 00:00:00
abstract::Congenital hypothyroidism (CH) can lead to irreversible central nervous system (CNS) damage. However, the pathogenesis of the developmental brain disorders caused by CH has not been completely elucidated. ARPC5 and CRMP2 are closely associated with neurite outgrowth in brain development. Thus, the aim of the present s...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5646
更新日期:2013-01-01 00:00:00
abstract::By introduction of Oct4, Sox2, Klf4 and cMyc, human adult somatic cells can be reprogrammed into embryonic stem cell capable of pluripotent differentiation. In several lines of human endometrial polyp- and cervical polyp-mesenchymal stem cells (EPMSCs and CPMSC), we showed introduction of the four transcription factor...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.23401
更新日期:2018-09-07 00:00:00
abstract::Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96). In the present study we demonstrate the sulfation of a salivary secretory...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.237
更新日期:2007-03-02 00:00:00
abstract::In order to find a blood host and to select appropriate oviposition sites female Anopheles gambiae mosquitoes rely on olfactory cues which are sensed by olfactory sensory neurons (OSNs) located within morphologically different sensilla hairs. While the sharp type trichoid sensilla are most abundant and intensely studi...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8754
更新日期:2014-03-22 00:00:00
abstract::Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is known to modulate cell proliferation, differentiation, and migration, all of which are features of ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3579
更新日期:2012-01-01 00:00:00
abstract::A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and screening the candidates of therapeutic drug. We have first performed the cell identification and morpholo...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5115
更新日期:2013-01-01 00:00:00