Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages.

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：:Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...

journal_title：International journal of biological sciences

authors： Li X,Kazgan N

更新日期：2011-01-01 00:00:00

abstract：:Cardiac metabolic remodeling is recognized as an important hallmark of heart failure (HF), while strategies that target energy metabolism have therapeutic potential in treating HF. Shen-Fu formula (S-F) is a standardized herbal preparation frequently used in clinical practice and is a promising combinatorial therapy f...

journal_title：International journal of biological sciences

authors： Huang Y,Zhang K,Jiang M,Ni J,Chen J,Li L,Deng J,Zhu Y,Mao J,Gao X,Fan G

更新日期：2020-10-16 00:00:00

abstract：:Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces disease activity in RA, although its mechanisms of action remain unclear. Since IL-6 regulates cytokine production by CD4 T cells during activation,...

journal_title：International journal of biological sciences

authors： Carbone G,Wilson A,Diehl SA,Bunn J,Cooper SM,Rincon M

更新日期：2013-01-01 00:00:00

abstract：:Congenital hypothyroidism (CH) can lead to irreversible central nervous system (CNS) damage. However, the pathogenesis of the developmental brain disorders caused by CH has not been completely elucidated. ARPC5 and CRMP2 are closely associated with neurite outgrowth in brain development. Thus, the aim of the present s...

journal_title：International journal of biological sciences

authors： Liu CR,Miao J,Zhang YL,Liu YM,Yu BG

更新日期：2013-01-01 00:00:00

abstract：:Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

journal_title：International journal of biological sciences

authors： Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

更新日期：2020-01-01 00:00:00

abstract：:D-Xylitol is found in low content as a natural constituent of many fruits and vegetables. It is a five-carbon sugar polyol and has been used as a food additive and sweetening agent to replace sucrose, especially for non-insulin dependent diabetics. It has multiple beneficial health effects, such as the prevention of d...

journal_title：International journal of biological sciences

authors： Chen X,Jiang ZH,Chen S,Qin W

更新日期：2010-12-15 00:00:00

abstract：:Focal adhesion kinase (FAK) is a major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling pathways. FAK is overexpressed and/or activated in many types of human tumors, in which it promotes cell adhesion, survival, migration and invasion. In addition to FAK's ability ...

journal_title：International journal of biological sciences

authors： Dwyer SF,Gao L,Gelman IH

更新日期：2015-02-17 00:00:00

abstract：:Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in...

journal_title：International journal of biological sciences

authors： Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PC

更新日期：2020-01-01 00:00:00

abstract：:Type 2 diabetes mellitus is characterized by insulin resistance. However, the complete molecular mechanism remains unclear. In this study, zebrafish were fed a long-term high-fat diet to induce type 2 diabetes, which resulted in a higher body weight, body mass index, more lipid vacuoles in liver, increased insulin tra...

journal_title：International journal of biological sciences

authors： Meng XH,Chen B,Zhang JP

更新日期：2017-07-18 00:00:00

abstract：:Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

journal_title：International journal of biological sciences

authors： Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

更新日期：2018-04-05 00:00:00

abstract：:Dihydropyrimidinase-related protein 4 (Dpysl4) is a known regulator of hippocampal neuron development. Here, we report that Dpysl4 is involved in growth regulation, polarization and differentiation of dental epithelial cells during tooth germ morphogenesis. A reduction in Dpysl4 gene expression in the tooth germ produ...

journal_title：International journal of biological sciences

authors： Yasukawa M,Ishida K,Yuge Y,Hanaoka M,Minami Y,Ogawa M,Sasaki T,Saito M,Tsuji T

更新日期：2013-04-26 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. Th...

journal_title：International journal of biological sciences

authors： Guo Z,Qiu Y

更新日期：2011-01-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elu...

journal_title：International journal of biological sciences

authors： Liu F,Xia Z,Zhang M,Ding J,Feng Y,Wu J,Dong Y,Gao W,Han Z,Liu Y,Yao Y,Li D

更新日期：2019-01-01 00:00:00

abstract：:Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

journal_title：International journal of biological sciences

authors： Yang N,Shen HM

更新日期：2020-03-15 00:00:00

abstract：:The gene encoding PDX1 (pancreatic duodenum homeobox 1), the main transcription factor regulating the glucose-dependent transactivation of the insulin promoter in pancreatic beta-cells, clusters with two closely related homeobox genes (Gsh1 and Cdx2/3), all of them belonging to the ParaHox gene family. The ParaHox gen...

journal_title：International journal of biological sciences

authors： Rosanas-Urgell A,Garcia-Fernàndez J,Marfany G

更新日期：2008-02-06 00:00:00

abstract：:This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). In this study, GDM model was induced in late pregnant rat model. The alteration of ClC-2 expression in various ...

journal_title：International journal of biological sciences

authors： He F,Peng Y,Yang Z,Ge Z,Tian Y,Ma T,Li H

更新日期：2017-01-15 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) wild-type is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs). In this study, we assessed whether the combination of bisdemethoxycurcumin (BDMC) and icotinib could surmount primary EGFR-TKI resistance in NSCLC cells and inves...

journal_title：International journal of biological sciences

authors： Xiang M,Jiang HG,Shu Y,Chen YJ,Jin J,Zhu YM,Li MY,Wu JN,Li J

更新日期：2020-03-05 00:00:00

abstract：:Hyperglycemia is known to exacerbate neuronal death resulted from cerebral ischemia. The mechanisms are not fully understood. The mammalian target of rapamycin (mTOR) pathway regulates cell growth, division and apoptosis. Recent studies suggest that activation of mTOR may mediate ischemic brain damage. The objective o...

journal_title：International journal of biological sciences

authors： Hei C,Liu P,Yang X,Niu J,Li PA

更新日期：2017-07-07 00:00:00

abstract：:Our previous studies indicated that phosphoinositide specific phospholipase Cγ1 (PLCγ1) was involved in autophagy induction in colon and hepatic carcinoma cells. However, whether and how PLCγ1 regulation in human lung adenocarcinoma is linked to autophagy remains unclear. Here, we assessed the protein expression of PL...

journal_title：International journal of biological sciences

authors： Lu X,Fu H,Chen R,Wang Y,Zhan Y,Song G,Hu T,Xia C,Tian X,Zhang B

更新日期：2020-02-21 00:00:00

abstract：PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...

journal_title：International journal of biological sciences

authors： Helms SA,Azhar G,Zuo C,Theus SA,Bartke A,Wei JY

更新日期：2010-09-01 00:00:00

abstract：:Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

journal_title：International journal of biological sciences

authors： Zhang Q,Dong J,Yu Z

更新日期：2020-08-13 00:00:00

abstract：:Structural maintenance of chromosomes protein 1A (SMC1A) has been implicated in the development of a variety of cancer types. However, its role in hepatocellular carcinoma remains unknown. In this study, we found that phosphorylated SMC1A was highly expressed in HepG2 and Bel7402 cells when compared with other cancer ...

journal_title：International journal of biological sciences

authors： Zhang Y,Yi F,Wang L,Wang Z,Zhang N,Wang Z,Li Z,Song X,Wei S,Cao L

更新日期：2018-06-08 00:00:00

abstract：:Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction ...

journal_title：International journal of biological sciences

authors： Lin X,Zhang Y,Liu L,McKeehan WL,Shen Y,Song S,Wang F

更新日期：2011-01-01 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

journal_title：International journal of biological sciences

authors： Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

更新日期：2018-07-27 00:00:00

abstract：:Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB) which leads to infiltration of blood cells, an inflammatory response, and neuronal cell death, resulting spinal cord secondary damage. Retinoic acid (RA) has a neuroprotective effect in both ischemic brain injury and SCI, however t...

journal_title：International journal of biological sciences

authors： Zhou Y,Zhang H,Zheng B,Ye L,Zhu S,Johnson NR,Wang Z,Wei X,Chen D,Cao G,Fu X,Li X,Xu HZ,Xiao J

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial dysfunction is an important contributor to the development of osteoarthritis (OA). Sirtuin 3 (SIRT3) regulates diverse mitochondrial proteins to maintain mitochondrial homeostasis, and dihydromyricetin (DHM) is reported as a potential SIRT3 activator. This study aims to explore the relevance of SIRT3 and...

journal_title：International journal of biological sciences

authors： Wang J,Wang K,Huang C,Lin D,Zhou Y,Wu Y,Tian N,Fan P,Pan X,Xu D,Hu J,Zhou Y,Wang X,Zhang X

更新日期：2018-10-20 00:00:00

abstract：:Toll-like receptor (TLR) signaling is an emerging pathway in tumor cell invasion and metastasis. Myeloid differentiation protein-2 (MD2) contributes to ligand recognition and activation of TLRs in response to exogenous microbial insults or endogenous agents. We hypothesized that blocking MD2 using a specific inhibitor...

journal_title：International journal of biological sciences

authors： Rajamanickam V,Yan T,Xu S,Hui J,Xu X,Ren L,Liu Z,Liang G,Wang O,Wang Y

更新日期：2020-02-17 00:00:00

abstract：:Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...

journal_title：International journal of biological sciences

authors： Min H,Lee JY,Kim MH

更新日期：2012-01-01 00:00:00