Abstract:
:Structural maintenance of chromosomes protein 1A (SMC1A) has been implicated in the development of a variety of cancer types. However, its role in hepatocellular carcinoma remains unknown. In this study, we found that phosphorylated SMC1A was highly expressed in HepG2 and Bel7402 cells when compared with other cancer cell lines. Furthermore, SMC1A knockdown dramatically reduced HepG2 and Bel7402 cell proliferation and migration. Re-expressing phosphomimetic mutants S957DS966D significantly enhanced the proliferation and migration of SMC1A knockdown HepG2 and Bel7402 cells. In addition, phosphorylated SMC1A promotes hepatocellular carcinoma cells growth in vivo. Importantly, the expression of phosphorylated SMC1A was significantly higher in human hepatocellular carcinomacells when compared to peri-tumor benign hepatocytes, and its overexpression was significantly associated with worse prognostic outcomes. These observations suggest that phosphorylation of SMC1A is a vital event in tumorigenesis and disease progression in hepatocellular carcinoma thus necessitating further investigation.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Zhang Y,Yi F,Wang L,Wang Z,Zhang N,Wang Z,Li Z,Song X,Wei S,Cao Ldoi
10.7150/ijbs.24692subject
Has Abstractpub_date
2018-06-08 00:00:00pages
1081-1089issue
9issn
1449-2288pii
ijbsv14p1081journal_volume
14pub_type
杂志文章abstract::Pork quality is an economically important trait and one of the main selection criteria for breeding in the swine industry. In this genome-wide association study (GWAS), 455 pigs from a porcine Large White × Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip, and phenotyped for intram...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3614
更新日期:2012-01-01 00:00:00
abstract::Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.30348
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abstract::Carbon monoxide (CO) is a vasoactive molecule that is generated by vascular cells as a byproduct of heme catabolism and it plays an important physiological role in circulation system. In order to investigate whether exogenous CO can mediate the growth and proliferation of vascular cells, in this study, we used 250 par...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.4664
更新日期:2012-01-01 00:00:00
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journal_title:International journal of biological sciences
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doi:10.7150/ijbs.7.1391
更新日期:2011-01-01 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17696
更新日期:2017-01-11 00:00:00
abstract::Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
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更新日期:2014-01-10 00:00:00
abstract::Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:International journal of biological sciences
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doi:10.7150/ijbs.39947
更新日期:2020-03-26 00:00:00
abstract::A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evident...
journal_title:International journal of biological sciences
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doi:10.7150/ijbs.2.110
更新日期:2006-01-01 00:00:00
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journal_title:International journal of biological sciences
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doi:10.7150/ijbs.27537
更新日期:2019-01-01 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5136
更新日期:2012-01-01 00:00:00
abstract::It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.24548
更新日期:2018-05-22 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13269
更新日期:2016-01-28 00:00:00
abstract::Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8134
更新日期:2014-03-10 00:00:00
abstract::The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent years and is now relatively established. Here we discuss the role...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.5.44
更新日期:2009-01-01 00:00:00
abstract::Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.4438
更新日期:2012-01-01 00:00:00
abstract::In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7242
更新日期:2013-11-05 00:00:00
abstract:PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6.475
更新日期:2010-09-01 00:00:00
abstract::Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.42965
更新日期:2020-08-13 00:00:00
abstract::The effects of hormonal and dietary stimuli on hepatic glucose and lipid homeostasis include regulation of gene expression. Berberine, an effective compound in certain Chinese medicinal herbs, has been reported to lower plasma glucose and lipid levels in diabetic and hypercholesterolemic patients. We hypothesized that...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.673
更新日期:2011-01-01 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:International journal of biological sciences
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更新日期:2020-01-01 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.393
更新日期:2007-09-12 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5711
更新日期:2013-08-14 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.43447
更新日期:2020-03-12 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
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更新日期:2016-06-24 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.46822
更新日期:2020-07-19 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.3.420
更新日期:2007-10-25 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8754
更新日期:2014-03-22 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17948
更新日期:2017-10-17 00:00:00