Structural dynamics and epigenetic modifications of Hoxc loci along the anteroposterior body axis in developing mouse embryos.

abstract：:Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...

journal_title：International journal of biological sciences

authors： Zhou Q,Li M,Wang X,Li Q,Wang T,Zhu Q,Zhou X,Wang X,Gao X,Li X

更新日期：2012-01-01 00:00:00

abstract：:The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in multiple types of tum...

journal_title：International journal of biological sciences

authors： Chen Z,Liu J,Chu D,Shan Y,Ma G,Zhang H,Zhang XD,Wang P,Chen Q,Deng C,Chen W,Dimitrov DS,Zhao Q

更新日期：2018-05-21 00:00:00

abstract：:Germ cells produce sperm and eggs for reproduction and fertility. The Asian seabass (Lates calcarifer), a protandrous marine fish, undergoes male-female sex reversal and thus offers an excellent model to study the role of germ cells in sex differentiation and sex reversal. Here we report the cloning and expression of ...

journal_title：International journal of biological sciences

authors： Xu H,Lim M,Dwarakanath M,Hong Y

更新日期：2014-02-06 00:00:00

abstract：:Toll-like receptor (TLR) signaling is an emerging pathway in tumor cell invasion and metastasis. Myeloid differentiation protein-2 (MD2) contributes to ligand recognition and activation of TLRs in response to exogenous microbial insults or endogenous agents. We hypothesized that blocking MD2 using a specific inhibitor...

journal_title：International journal of biological sciences

authors： Rajamanickam V,Yan T,Xu S,Hui J,Xu X,Ren L,Liu Z,Liang G,Wang O,Wang Y

更新日期：2020-02-17 00:00:00

abstract：:Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

journal_title：International journal of biological sciences

authors： Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

更新日期：2020-01-01 00:00:00

abstract：:Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the pathogenesis of S...

journal_title：International journal of biological sciences

authors： Peng Q,Xu H,Xiao M,Wang L

更新日期：2020-09-19 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00

abstract：BACKGROUND:To evaluate the promoter methylation status of RECK gene and mRNA expression in patients with hepatocellular carcinoma (HCC). METHODS:We analyzed RECK methylation by MSP, and RECK mRNA by real-time PCR in 74 HCC. The liver cell lines (7721, Chang and Hep-G2) were treated with 5-Aza-CdR and TSA. RESULTS:REC...

journal_title：International journal of biological sciences

authors： Zhang C,Ling Y,Zhang C,Xu Y,Gao L,Li R,Zhu J,Fan L,Wei L

更新日期：2012-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a tumor subtype with aggressive behavior and poor clinical outcome for lacking effective therapies. Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness...

journal_title：International journal of biological sciences

authors： Yang F,Cao L,Sun Z,Jin J,Fang H,Zhang W,Guan X

更新日期：2016-12-07 00:00:00

abstract：:Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs). In the current study, we investigated whether NPCs expressing Vascula...

journal_title：International journal of biological sciences

authors： Maurer MH,Thomas C,Bürgers HF,Kuschinsky W

更新日期：2007-12-03 00:00:00

abstract：:Different stimuli often activate the same intracellular signaling molecules but trigger distinct cell responses. We explored whether or not MAPK signaling induced by macrophage colony-stimulating factor (M-CSF), which is responsible for osteoclast proliferation, differs from that induced by receptor activator of NF-κB...

journal_title：International journal of biological sciences

authors： Lee K,Chung YH,Ahn H,Kim H,Rho J,Jeong D

更新日期：2016-01-01 00:00:00

abstract：:BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues....

journal_title：International journal of biological sciences

authors： Baek HJ,Kim SE,Choi EK,Kim JK,Shin DH,Park EJ,Kim TH,Kim JY,Kim KG,Deng CX,Kim SS

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...

journal_title：International journal of biological sciences

authors： Qu W,Xiao J,Zhang H,Chen Q,Wang Z,Shi H,Gong L,Chen J,Liu Y,Cao R,Lv J

更新日期：2013-08-14 00:00:00

abstract：:β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in C2C12 myoblasts. This effect is partly due to the enhanced stability of p27, r...

journal_title：International journal of biological sciences

authors： Chen M,Liu C,Wang M,Wang H,Zhang K,Zheng Y,Yu Z,Li X,Guo W,Li N,Meng Q

更新日期：2017-10-17 00:00:00

abstract：BACKGROUND & OBJECTIVE:The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to drug resistance. Therefore, it is critical to find a novel pr...

journal_title：International journal of biological sciences

authors： Lu J,Zhan Y,Feng J,Luo J,Fan S

更新日期：2018-03-10 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FLSs). FLSs were isol...

journal_title：International journal of biological sciences

authors： Fan L,Zong M,Gong R,He D,Li N,Sun LS,Ye Q,Yu S

更新日期：2017-02-25 00:00:00

abstract：:Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect neuronal cells against oxidative stress in neurodegenerative diseases. The present study was designed to examine whether CoQ10 was capable of protecting astrocytes from reactive oxygen species (ROS) mediated damage. For this purpose, ultraviole...

journal_title：International journal of biological sciences

authors： Jing L,He MT,Chang Y,Mehta SL,He QP,Zhang JZ,Li PA

更新日期：2015-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased i...

journal_title：International journal of biological sciences

authors： Chu C,Liu X,Bai X,Zhao T,Wang M,Xu R,Li M,Hu Y,Li W,Yang L,Qin Y,Yang M,Yan C,Zhang Y

更新日期：2018-02-09 00:00:00

abstract：:TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral sclerosis (ALS) that is characterized by progressive degeneration of motor neurons. To better understand the correlation of A...

journal_title：International journal of biological sciences

authors： Huang C,Xia PY,Zhou H

更新日期：2010-07-04 00:00:00

abstract：PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...

journal_title：International journal of biological sciences

authors： Helms SA,Azhar G,Zuo C,Theus SA,Bartke A,Wei JY

更新日期：2010-09-01 00:00:00

abstract：:Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

journal_title：International journal of biological sciences

authors： Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

更新日期：2018-06-03 00:00:00

abstract：:Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular cargos, including long noncoding RNAs (lncRNAs). Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a well-known lncRNA associated with cancer angiogenesis and metastasis. However, the presence of MALAT1 in exoso...

journal_title：International journal of biological sciences

authors： Qiu JJ,Lin XJ,Tang XY,Zheng TT,Lin YY,Hua KQ

更新日期：2018-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

journal_title：International journal of biological sciences

authors： Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

更新日期：2020-02-04 00:00:00

abstract：:About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

journal_title：International journal of biological sciences

authors： Guan R,Wen X,Liang Y,Xu D,He B,Feng X

更新日期：2019-08-06 00:00:00

abstract：:Background: The monitoring and management of blood glucose concentration are standard practices in critical settings as hyperglycaemia has been shown close association with poorer outcomes. Several meta-analyses have revealed that intensive glucose control has no benefit in decreasing short-term mortality among critic...

journal_title：International journal of biological sciences

authors： Yao RQ,Ren C,Wu GS,Zhu YB,Xia ZF,Yao YM

更新日期：2020-03-12 00:00:00

abstract：:The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

journal_title：International journal of biological sciences

authors： Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

更新日期：2019-07-25 00:00:00

abstract：:Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the priori knowledge about the physiological, biochemical or functional ...

journal_title：International journal of biological sciences

authors： Zhu M,Zhao S

更新日期：2007-10-25 00:00:00

abstract：:Reverting activated hepatic stellate cells (HSCs) to less activation or quiescent status is a promising strategy for liver fibrosis. Histone deacetylase inhibitor (HDACI) could suppress HSCs activation. Our previous study demonstrated a critical role of miRNAs in HSCs activation. Here, we explored the involvement of m...

journal_title：International journal of biological sciences

authors： Lu P,Yan M,He L,Li J,Ji Y,Ji J

更新日期：2019-01-06 00:00:00

abstract：:Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell ...

journal_title：International journal of biological sciences

authors： López-Navarrete G,Ramos-Martínez E,Suárez-Álvarez K,Aguirre-García J,Ledezma-Soto Y,León-Cabrera S,Gudiño-Zayas M,Guzmán C,Gutiérrez-Reyes G,Hernández-Ruíz J,Camacho-Arroyo I,Robles-Díaz G,Kershenobich D,Terrazas LI,Escobedo

更新日期：2011-01-01 00:00:00

abstract：:The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors. In 1996, we and others identified a superfamily of "regulator of G-protein signaling" (RGS) proteins that acc...

journal_title：International journal of biological sciences

authors： Siderovski DP,Willard FS

更新日期：2005-01-01 00:00:00