The Effect of Estradiol on the Growth Plate Chondrocytes of Limb and Spine from Postnatal Mice in vitro: The Role of Estrogen-Receptor and Estradiol Concentration.

abstract：:Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased i...

journal_title：International journal of biological sciences

authors： Chu C,Liu X,Bai X,Zhao T,Wang M,Xu R,Li M,Hu Y,Li W,Yang L,Qin Y,Yang M,Yan C,Zhang Y

更新日期：2018-02-09 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

journal_title：International journal of biological sciences

authors： Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

更新日期：2020-02-04 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

journal_title：International journal of biological sciences

authors： Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

更新日期：2019-09-07 00:00:00

abstract：:Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

journal_title：International journal of biological sciences

authors： Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

更新日期：2019-11-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specifi...

journal_title：International journal of biological sciences

authors： Yang G,Yang X

更新日期：2010-01-01 00:00:00

abstract：:Pathogens have developed strategies to modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their survival. DCs responses to helminths and their derivatives vary among different studies. Here we show that excretory/secretory products of the cestode Taenia crassi...

journal_title：International journal of biological sciences

authors： Terrazas CA,Sánchez-Muñoz F,Mejía-Domínguez AM,Amezcua-Guerra LM,Terrazas LI,Bojalil R,Gómez-García L

更新日期：2011-01-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). In this study, GDM model was induced in late pregnant rat model. The alteration of ClC-2 expression in various ...

journal_title：International journal of biological sciences

authors： He F,Peng Y,Yang Z,Ge Z,Tian Y,Ma T,Li H

更新日期：2017-01-15 00:00:00

abstract：:The effects of hormonal and dietary stimuli on hepatic glucose and lipid homeostasis include regulation of gene expression. Berberine, an effective compound in certain Chinese medicinal herbs, has been reported to lower plasma glucose and lipid levels in diabetic and hypercholesterolemic patients. We hypothesized that...

journal_title：International journal of biological sciences

authors： Ge Y,Zhang Y,Li R,Chen W,Li Y,Chen G

更新日期：2011-01-01 00:00:00

abstract：:A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evident...

journal_title：International journal of biological sciences

authors： Langeland JA,Holland LZ,Chastain RA,Holland ND

更新日期：2006-01-01 00:00:00

abstract：:Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

journal_title：International journal of biological sciences

authors： Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

更新日期：2014-03-10 00:00:00

abstract：:Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for the prevention and treatment of inflammatory bone los...

journal_title：International journal of biological sciences

authors： Kwak SC,Baek JM,Lee CH,Yoon KH,Lee MS,Kim JY

更新日期：2019-09-07 00:00:00

abstract：:Emerging evidence has indicated that abnormal microRNAs (miRNAs) participated in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). Better understanding the association between miRNAs and HCC may contribute to discover novel therapeutic approaches for diagnosis and treatments. In the current study...

journal_title：International journal of biological sciences

authors： Wang L,Sun L,Wang Y,Yao B,Liu R,Chen T,Tu K,Liu Q,Liu Z

更新日期：2019-06-02 00:00:00

abstract：:Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...

journal_title：International journal of biological sciences

authors： Zhao L,Zhou C,Zhang J,Gao F,Li B,Chuai Y,Liu C,Cai J

更新日期：2011-03-25 00:00:00

abstract：:Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96). In the present study we demonstrate the sulfation of a salivary secretory...

journal_title：International journal of biological sciences

authors： Kasinathan C,Gandhi N,Ramaprasad P,Sundaram P,Ramasubbu N

更新日期：2007-03-02 00:00:00

abstract：:Carbon monoxide (CO) is a vasoactive molecule that is generated by vascular cells as a byproduct of heme catabolism and it plays an important physiological role in circulation system. In order to investigate whether exogenous CO can mediate the growth and proliferation of vascular cells, in this study, we used 250 par...

journal_title：International journal of biological sciences

authors： Li Y,Wang H,Yang B,Yang J,Ruan X,Yang Y,Wakeland EK,Li Q,Fang X

更新日期：2012-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma and play an essential role in tumor progression and metastasis in a variety of malignancies, including gastric cancer. However, the effects of CAFs on gastr...

journal_title：International journal of biological sciences

authors： Xu G,Zhang B,Ye J,Cao S,Shi J,Zhao Y,Wang Y,Sang J,Yao Y,Guan W,Tao J,Feng M,Zhang W

更新日期：2019-08-22 00:00:00

abstract：:Type 2 diabetes mellitus is characterized by insulin resistance. However, the complete molecular mechanism remains unclear. In this study, zebrafish were fed a long-term high-fat diet to induce type 2 diabetes, which resulted in a higher body weight, body mass index, more lipid vacuoles in liver, increased insulin tra...

journal_title：International journal of biological sciences

authors： Meng XH,Chen B,Zhang JP

更新日期：2017-07-18 00:00:00

abstract：:Capsaicin is the major pungent ingredient in red peppers which is world widely consumed. Except its potent pain relieving efficacy as reported, capsaicin also exerted its antitumor activity in several tumor models. Here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells vi...

journal_title：International journal of biological sciences

authors： Jin J,Lin G,Huang H,Xu D,Yu H,Ma X,Zhu L,Ma D,Jiang H

更新日期：2014-02-21 00:00:00

abstract：:Non-coding RNAs (ncRNAs) are transcribed from genome but not translated into proteins. Many ncRNAs are key regulators of plants growth and development, metabolism and stress tolerance. In order to make the web-based ncRNA resources for plant science research be more easily accessible and understandable, we made a comp...

journal_title：International journal of biological sciences

authors： Liao P,Li S,Cui X,Zheng Y

更新日期：2018-05-22 00:00:00

abstract：:Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

journal_title：International journal of biological sciences

authors： Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

更新日期：2018-04-05 00:00:00

abstract：:Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). The receptors AgOR1 and AgOR2, as well as the binding protein AgOBP1, have been implicated in the recognition of human host odors. ...

journal_title：International journal of biological sciences

authors： Schymura D,Forstner M,Schultze A,Kröber T,Swevers L,Iatrou K,Krieger J

更新日期：2010-10-08 00:00:00

abstract：:N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases...

journal_title：International journal of biological sciences

authors： Zhu ZM,Huo FC,Pei DS

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...

journal_title：International journal of biological sciences

authors： Qu W,Xiao J,Zhang H,Chen Q,Wang Z,Shi H,Gong L,Chen J,Liu Y,Cao R,Lv J

更新日期：2013-08-14 00:00:00

abstract：:The development of alternative energy technology is critically important because of the rising prices of crude oil, security issues regarding the oil supply, and environmental issues such as global warming and air pollution. Bioconversion of biomass has significant advantages over other alternative energy strategies b...

journal_title：International journal of biological sciences

authors： Dashtban M,Schraft H,Qin W

更新日期：2009-09-04 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies in...

journal_title：International journal of biological sciences

authors： Guo SC,Tao SC,Yin WJ,Qi X,Sheng JG,Zhang CQ

更新日期：2016-10-17 00:00:00

abstract：:Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...

journal_title：International journal of biological sciences

authors： Li X,Kazgan N

更新日期：2011-01-01 00:00:00

abstract：:Mitochondrial function is of particular importance in brain because of its high demand for energy (ATP) and efficient removal of reactive oxygen species (ROS). We developed rat mitochondrion-neuron focused microarray (rMNChip) and integrated bioinformatics tools for rapid identification of differential pathways in bra...

journal_title：International journal of biological sciences

authors： Su YA,Zhang Q,Su DM,Tang MX

更新日期：2011-03-29 00:00:00