Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53.

abstract：:Patent ductus arteriosus (PDA) can cause morbidity and mortality in neonates. Vascular remodeling, characterized by proliferation and migration of smooth muscle cells (SMCs), is an essential process for postnatal DA closure. Notch signaling is an important mediator of vascular remodelling but its role in DA is unkonwn...

journal_title：International journal of biological sciences

authors： Wu JR,Yeh JL,Liou SF,Dai ZK,Wu BN,Hsu JH

更新日期：2016-07-18 00:00:00

abstract：:Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96). In the present study we demonstrate the sulfation of a salivary secretory...

journal_title：International journal of biological sciences

authors： Kasinathan C,Gandhi N,Ramaprasad P,Sundaram P,Ramasubbu N

更新日期：2007-03-02 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:Germ cells produce sperm and eggs for reproduction and fertility. The Asian seabass (Lates calcarifer), a protandrous marine fish, undergoes male-female sex reversal and thus offers an excellent model to study the role of germ cells in sex differentiation and sex reversal. Here we report the cloning and expression of ...

journal_title：International journal of biological sciences

authors： Xu H,Lim M,Dwarakanath M,Hong Y

更新日期：2014-02-06 00:00:00

abstract：:Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry. However, the developmental role of Wee1 in mammals remains unclear. In this study, we es...

journal_title：International journal of biological sciences

authors： Tominaga Y,Li C,Wang RH,Deng CX

更新日期：2006-01-01 00:00:00

abstract：:Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the pathogenesis of S...

journal_title：International journal of biological sciences

authors： Peng Q,Xu H,Xiao M,Wang L

更新日期：2020-09-19 00:00:00

abstract：BACKGROUND:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate and have become novel signaling targets for the development of cancer therapeutic drugs. Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical t...

journal_title：International journal of biological sciences

authors： Qu W,Xiao J,Zhang H,Chen Q,Wang Z,Shi H,Gong L,Chen J,Liu Y,Cao R,Lv J

更新日期：2013-08-14 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Ferroptosis, an iron-dependent form of regulated cell death, can be induced by sorafenib. However, the prognostic value of ferroptosis-related genes in HCC remains to be further elucidated. In this stud...

journal_title：International journal of biological sciences

authors： Liang JY,Wang DS,Lin HC,Chen XX,Yang H,Zheng Y,Li YH

更新日期：2020-07-06 00:00:00

abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

journal_title：International journal of biological sciences

authors： Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

更新日期：2018-01-01 00:00:00

abstract：: Objectives: Skeletal development is a complex process. Little is known about the different response of limb or spine growth plate chondrocytes (LGP or SGP) to the estrogen level and the role of estrogen receptor (ER) during postnatal stage. Methods...

journal_title：International journal of biological sciences

authors： Shi S,Zheng S,Li XF,Liu ZD

更新日期：2017-01-11 00:00:00

abstract：:Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

journal_title：International journal of biological sciences

authors： Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

更新日期：2018-06-03 00:00:00

abstract：:Focal adhesion kinase (FAK) is a major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling pathways. FAK is overexpressed and/or activated in many types of human tumors, in which it promotes cell adhesion, survival, migration and invasion. In addition to FAK's ability ...

journal_title：International journal of biological sciences

authors： Dwyer SF,Gao L,Gelman IH

更新日期：2015-02-17 00:00:00

abstract：:Mitochondrial function is of particular importance in brain because of its high demand for energy (ATP) and efficient removal of reactive oxygen species (ROS). We developed rat mitochondrion-neuron focused microarray (rMNChip) and integrated bioinformatics tools for rapid identification of differential pathways in bra...

journal_title：International journal of biological sciences

authors： Su YA,Zhang Q,Su DM,Tang MX

更新日期：2011-03-29 00:00:00

abstract：:Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head (ONFH), and vitamin K2 (VK2) has been shown to play an important and beneficial role in bone metabolism. In this study, we hypothesized that VK2 could decrease the incidence of glucocorticoid-induced ONFH in a ra...

journal_title：International journal of biological sciences

authors： Zhang YL,Yin JH,Ding H,Zhang W,Zhang CQ,Gao YS

更新日期：2016-01-28 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases....

journal_title：International journal of biological sciences

authors： Wang H,Lafdil F,Kong X,Gao B

更新日期：2011-04-27 00:00:00

abstract：:Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). The receptors AgOR1 and AgOR2, as well as the binding protein AgOBP1, have been implicated in the recognition of human host odors. ...

journal_title：International journal of biological sciences

authors： Schymura D,Forstner M,Schultze A,Kröber T,Swevers L,Iatrou K,Krieger J

更新日期：2010-10-08 00:00:00

abstract：:By introduction of Oct4, Sox2, Klf4 and cMyc, human adult somatic cells can be reprogrammed into embryonic stem cell capable of pluripotent differentiation. In several lines of human endometrial polyp- and cervical polyp-mesenchymal stem cells (EPMSCs and CPMSC), we showed introduction of the four transcription factor...

journal_title：International journal of biological sciences

authors： Ding DC,Chu TY,Liu HW

更新日期：2018-09-07 00:00:00

abstract：:Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...

journal_title：International journal of biological sciences

authors： Cao P,Xia Y,He W,Zhang T,Hong L,Zheng P,Shen X,Liang G,Cui R,Zou P

更新日期：2019-06-04 00:00:00

abstract：:Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative approaches in muscle regeneration. The aim of the study was to demonstrate cryogel scaffold potential in the field of ...

journal_title：International journal of biological sciences

authors： Singh D,Nayak V,Kumar A

更新日期：2010-07-03 00:00:00

abstract：:Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A. In this study we aimed to compare both cell lines on applicability in BALs...

journal_title：International journal of biological sciences

authors： van Wenum M,Adam AA,Hakvoort TB,Hendriks EJ,Shevchenko V,van Gulik TM,Chamuleau RA,Hoekstra R

更新日期：2016-06-24 00:00:00

abstract：:Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell ...

journal_title：International journal of biological sciences

authors： López-Navarrete G,Ramos-Martínez E,Suárez-Álvarez K,Aguirre-García J,Ledezma-Soto Y,León-Cabrera S,Gudiño-Zayas M,Guzmán C,Gutiérrez-Reyes G,Hernández-Ruíz J,Camacho-Arroyo I,Robles-Díaz G,Kershenobich D,Terrazas LI,Escobedo

更新日期：2011-01-01 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...

journal_title：International journal of biological sciences

authors： Jia S,Zhao L,Tang W,Luo Y

更新日期：2012-01-01 00:00:00

abstract：:Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB) which leads to infiltration of blood cells, an inflammatory response, and neuronal cell death, resulting spinal cord secondary damage. Retinoic acid (RA) has a neuroprotective effect in both ischemic brain injury and SCI, however t...

journal_title：International journal of biological sciences

authors： Zhou Y,Zhang H,Zheng B,Ye L,Zhu S,Johnson NR,Wang Z,Wei X,Chen D,Cao G,Fu X,Li X,Xu HZ,Xiao J

更新日期：2016-01-01 00:00:00

abstract：:Structural maintenance of chromosomes protein 1A (SMC1A) has been implicated in the development of a variety of cancer types. However, its role in hepatocellular carcinoma remains unknown. In this study, we found that phosphorylated SMC1A was highly expressed in HepG2 and Bel7402 cells when compared with other cancer ...

journal_title：International journal of biological sciences

authors： Zhang Y,Yi F,Wang L,Wang Z,Zhang N,Wang Z,Li Z,Song X,Wei S,Cao L

更新日期：2018-06-08 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specifi...

journal_title：International journal of biological sciences

authors： Yang G,Yang X

更新日期：2010-01-01 00:00:00

abstract：:Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for the prevention and treatment of inflammatory bone los...

journal_title：International journal of biological sciences

authors： Kwak SC,Baek JM,Lee CH,Yoon KH,Lee MS,Kim JY

更新日期：2019-09-07 00:00:00

abstract：:Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...

journal_title：International journal of biological sciences

authors： Wu YL,Ding YP,Tanaka Y,Shen LW,Wei CH,Minato N,Zhang W

更新日期：2014-01-10 00:00:00

abstract：:The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent years and is now relatively established. Here we discuss the role...

journal_title：International journal of biological sciences

authors： Thornton TM,Rincon M

更新日期：2009-01-01 00:00:00

abstract：:The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others...

journal_title：International journal of biological sciences

authors： Logsdon CD,Lu W

更新日期：2016-01-28 00:00:00