Interleukin-8 regulates endothelial permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions.

abstract：:Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) wild-type is intrinsic resistance to EGFR-tyrosine kinase inhibitors (TKIs). In this study, we assessed whether the combination of bisdemethoxycurcumin (BDMC) and icotinib could surmount primary EGFR-TKI resistance in NSCLC cells and inves...

journal_title：International journal of biological sciences

authors： Xiang M,Jiang HG,Shu Y,Chen YJ,Jin J,Zhu YM,Li MY,Wu JN,Li J

更新日期：2020-03-05 00:00:00

abstract：:The objective of this study was to study the effect of diabetic hyperglycemia on astrocytes after forebrain ischemia. Streptozotocin (STZ)-injected hyperglycemic and vehicle-injected normoglycemic rats were subjected to 15 minutes of forebrain ischemia. The brains were harvested in sham-operated controls and in animal...

journal_title：International journal of biological sciences

authors： Jing L,Mai L,Zhang JZ,Wang JG,Chang Y,Dong JD,Guo FY,Li PA

更新日期：2013-09-25 00:00:00

abstract：:Gene silencing techniques are widely used to control gene expression and have potential for RNAi-based therapeutics. In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter. ...

journal_title：International journal of biological sciences

authors： Ajiro M,Jia R,Wang RH,Deng CX,Zheng ZM

更新日期：2015-09-03 00:00:00

abstract：:In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

journal_title：International journal of biological sciences

authors： Yao W,Shen Z,Ding G

更新日期：2013-11-05 00:00:00

abstract：:Bluetongue virus (BTV) replicates in lymphoid tissues where infected mononuclear leukocytes secrete proinflammatory and vasoactive mediators that can contribute to bluetongue (BT) pathogenesis. Using the well-characterized IFNAR(-/-) mice animal model, we have now studied the histopathology and dynamics of leukocyte p...

journal_title：International journal of biological sciences

authors： Marín-López A,Bermúdez R,Calvo-Pinilla E,Moreno S,Brun A,Ortego J

更新日期：2016-11-24 00:00:00

abstract：:Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). The receptors AgOR1 and AgOR2, as well as the binding protein AgOBP1, have been implicated in the recognition of human host odors. ...

journal_title：International journal of biological sciences

authors： Schymura D,Forstner M,Schultze A,Kröber T,Swevers L,Iatrou K,Krieger J

更新日期：2010-10-08 00:00:00

abstract：:In China, Bemisia tabaci Q (commonly known as biotype Q) has rapidly displaced B (commonly known as biotype B) in the past 6 years. The mechanisms underlying such phenomenon have been studied extensively in recent years; however, we have not come to a definitive conclusion yet. In the present study, the differences in...

journal_title：International journal of biological sciences

authors： Liu B,Yan F,Chu D,Pan H,Jiao X,Xie W,Wu Q,Wang S,Xu B,Zhou X,Zhang Y

更新日期：2012-01-01 00:00:00

abstract：:The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

journal_title：International journal of biological sciences

authors： Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

更新日期：2020-05-18 00:00:00

abstract：:Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...

journal_title：International journal of biological sciences

authors： Zhou Q,Li M,Wang X,Li Q,Wang T,Zhu Q,Zhou X,Wang X,Gao X,Li X

更新日期：2012-01-01 00:00:00

abstract：:A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and screening the candidates of therapeutic drug. We have first performed the cell identification and morpholo...

journal_title：International journal of biological sciences

authors： Xue Q,Liu Y,Qi H,Ma Q,Xu L,Chen W,Chen G,Xu X

更新日期：2013-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased i...

journal_title：International journal of biological sciences

authors： Chu C,Liu X,Bai X,Zhao T,Wang M,Xu R,Li M,Hu Y,Li W,Yang L,Qin Y,Yang M,Yan C,Zhang Y

更新日期：2018-02-09 00:00:00

abstract：PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...

journal_title：International journal of biological sciences

authors： Helms SA,Azhar G,Zuo C,Theus SA,Bartke A,Wei JY

更新日期：2010-09-01 00:00:00

abstract：:Small synthetic compounds have been implicated in treatment of human cancers. We have synthesized a small compound, BPR1K0609S1 (hereafter, BP), which inhibits Aurora-A kinase. In the present study, we studied the mechanism of BP suppression of tumorigenesis induced by Aurora-A. Given our previous results that inactiv...

journal_title：International journal of biological sciences

authors： Shionome Y,Lin WH,Shiao HY,Hsieh HP,Hsu JT,Ouchi T

更新日期：2013-04-29 00:00:00

abstract：:We collected clinical data from 308 prostate cancer (PCa) patients to investigate the clinical characteristics and independent risk factors of bone metastasis (BM) and to establish a prediction model for BM of PCa and determine the necessity of bone scans. Univariate and multivariate analyses were performed based on a...

journal_title：International journal of biological sciences

authors： Chen S,Wang L,Qian K,Jiang W,Deng H,Zhou Q,Wang G,Liu X,Wu CL,Xiao Y,Wang X

更新日期：2019-01-01 00:00:00

abstract：:Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction ...

journal_title：International journal of biological sciences

authors： Lin X,Zhang Y,Liu L,McKeehan WL,Shen Y,Song S,Wang F

更新日期：2011-01-01 00:00:00

abstract：:MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors. Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. In this study, we rep...

journal_title：International journal of biological sciences

authors： Zhang W,Duan N,Zhang Q,Song T,Li Z,Zhang C,Chen X,Wang K

更新日期：2017-04-10 00:00:00

abstract：:Well-orchestrated epigenetic modifications during early development are essential for embryonic survival and postnatal growth. Erroneous epigenetic modifications due to environmental perturbations such as manipulation and culture of embryos during in vitro fertilization (IVF) are linked to various short- or long-term ...

journal_title：International journal of biological sciences

authors： Fu W,Yue Y,Miao K,Xi G,Zhang C,Wang W,An L,Tian J

更新日期：2020-10-03 00:00:00

abstract：:To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...

journal_title：International journal of biological sciences

authors： Dai J,Li Y,Zhou H,Chen J,Chen M,Xiao Z

更新日期：2013-11-21 00:00:00

abstract：:Pathological cardiac hypertrophy is the response of heart to various biomechanical and physiopathological stimuli, such as aging, myocardial ischemia and hypertension. However, a long-term exposure to the stress makes heart progress to heart failure. Autophagy is a dynamic self-degradative process necessary for the ma...

journal_title：International journal of biological sciences

authors： Li Z,Wang J,Yang X

更新日期：2015-04-27 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies in...

journal_title：International journal of biological sciences

authors： Guo SC,Tao SC,Yin WJ,Qi X,Sheng JG,Zhang CQ

更新日期：2016-10-17 00:00:00

abstract：:This study aims to investigate the effect and mechanism of type 2 voltage-gated chloride channel (ClC-2) on myelin development of newborn rats' cerebral white matter with gestational diabetes mellitus (GDM). In this study, GDM model was induced in late pregnant rat model. The alteration of ClC-2 expression in various ...

journal_title：International journal of biological sciences

authors： He F,Peng Y,Yang Z,Ge Z,Tian Y,Ma T,Li H

更新日期：2017-01-15 00:00:00

abstract：:About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

journal_title：International journal of biological sciences

authors： Guan R,Wen X,Liang Y,Xu D,He B,Feng X

更新日期：2019-08-06 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00

abstract：:The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

journal_title：International journal of biological sciences

authors： Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

更新日期：2013-05-15 00:00:00

abstract：:Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

journal_title：International journal of biological sciences

authors： Yang N,Shen HM

更新日期：2020-03-15 00:00:00

abstract：:Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligome...

journal_title：International journal of biological sciences

authors： Li T,Liu J,Cai H,Wang B,Feng Y,Liu J

更新日期：2018-04-30 00:00:00

abstract：:Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-associated fibroblasts (CAFs) are a major component of the tumor stroma and play an essential role in tumor progression and metastasis in a variety of malignancies, including gastric cancer. However, the effects of CAFs on gastr...

journal_title：International journal of biological sciences

authors： Xu G,Zhang B,Ye J,Cao S,Shi J,Zhao Y,Wang Y,Sang J,Yao Y,Guan W,Tao J,Feng M,Zhang W

更新日期：2019-08-22 00:00:00

abstract：:Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...

journal_title：International journal of biological sciences

authors： Rao F,Wang T,Li M,Li Z,Hong N,Zhao H,Yan Y,Lu W,Chen T,Wang W,Lim M,Yuan Y,Liu L,Zeng L,Wei Q,Guan G,Li C,Hong Y

更新日期：2011-04-15 00:00:00

abstract：:Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed in...

journal_title：International journal of biological sciences

authors： Wang C,Zhao L,Lu S

更新日期：2015-02-05 00:00:00

abstract：:CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

journal_title：International journal of biological sciences

authors： Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

更新日期：2019-09-07 00:00:00