Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.

abstract：:Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...

journal_title：International journal of biological sciences

authors： Yao H,Teng Y,Sun Q,Xu J,Chen YT,Hou N,Cheng X,Yang X,Chen ZN

更新日期：2013-12-13 00:00:00

abstract：:Thymosin alpha 1 (Tα1) has immunomodulatory and anti-tumor effects in patients and has been commercialized in worldwide. An innovative technique is therefore impending to achieve high-yield expression and purification of Tα1 to meet the increasing requirements for clinical applications. Tα1 can enhance T cells, dendri...

journal_title：International journal of biological sciences

authors： Li W,Song L,Wu S,Xue X,Zhang L,He L,Han W,Wang Q,Ling R,Zhang W,Yan Z,Zhang Y

更新日期：2011-01-01 00:00:00

abstract：:Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer,...

journal_title：International journal of biological sciences

authors： Wang M,Jiang S,Zhou L,Yu F,Ding H,Li P,Zhou M,Wang K

更新日期：2019-05-07 00:00:00

abstract：:TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral sclerosis (ALS) that is characterized by progressive degeneration of motor neurons. To better understand the correlation of A...

journal_title：International journal of biological sciences

authors： Huang C,Xia PY,Zhou H

更新日期：2010-07-04 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:Different stimuli often activate the same intracellular signaling molecules but trigger distinct cell responses. We explored whether or not MAPK signaling induced by macrophage colony-stimulating factor (M-CSF), which is responsible for osteoclast proliferation, differs from that induced by receptor activator of NF-κB...

journal_title：International journal of biological sciences

authors： Lee K,Chung YH,Ahn H,Kim H,Rho J,Jeong D

更新日期：2016-01-01 00:00:00

abstract：:Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the A...

journal_title：International journal of biological sciences

authors： Cui H,Guo S,He H,Guo H,Zhang Y,Wang B

更新日期：2020-02-10 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...

journal_title：International journal of biological sciences

authors： Zhou Q,Li M,Wang X,Li Q,Wang T,Zhu Q,Zhou X,Wang X,Gao X,Li X

更新日期：2012-01-01 00:00:00

abstract：:The development of alternative energy technology is critically important because of the rising prices of crude oil, security issues regarding the oil supply, and environmental issues such as global warming and air pollution. Bioconversion of biomass has significant advantages over other alternative energy strategies b...

journal_title：International journal of biological sciences

authors： Dashtban M,Schraft H,Qin W

更新日期：2009-09-04 00:00:00

abstract：:Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect neuronal cells against oxidative stress in neurodegenerative diseases. The present study was designed to examine whether CoQ10 was capable of protecting astrocytes from reactive oxygen species (ROS) mediated damage. For this purpose, ultraviole...

journal_title：International journal of biological sciences

authors： Jing L,He MT,Chang Y,Mehta SL,He QP,Zhang JZ,Li PA

更新日期：2015-01-01 00:00:00

abstract：:Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it. We generated Elovl4 Y270X mutant mice and characterized the homozygous mutant as well as homozygous Elovl4 knockout ...

journal_title：International journal of biological sciences

authors： Cameron DJ,Tong Z,Yang Z,Kaminoh J,Kamiyah S,Chen H,Zeng J,Chen Y,Luo L,Zhang K

更新日期：2007-02-06 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a key process in EGFR-TKI resistance but the detailed mechanism is largely unknown. We aim to evaluate the role of interleukin-6 (IL-6) and insulin-like growth factor-1 receptor (IGR-1R) in EMT in non-small cell lung cancer (NSCLC). We used IL-6 to induce EMT in EGFR-TKI s...

journal_title：International journal of biological sciences

authors： Zheng X,Lu G,Yao Y,Gu W

更新日期：2019-07-20 00:00:00

abstract：OBJECTIVE:Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. METHODS:A total of 144 subjects were divided into 4 groups: normoglycemia (ND; 46 cases), mild gestational hyperglycemia (MGH; 30 cases), gestational diab...

journal_title：International journal of biological sciences

authors： Moreli JB,Santos JH,Lorenzon-Ojea AR,Corrêa-Silva S,Fortunato RS,Rocha CR,Rudge MV,Damasceno DC,Bevilacqua E,Calderon IM

更新日期：2016-02-12 00:00:00

abstract：OBJECTIVES:Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. We aimed to evaluate the relationship of MDA and GPx levels wit...

journal_title：International journal of biological sciences

authors： Hsieh YY,Chang CC,Lin CS

更新日期：2006-01-01 00:00:00

abstract：:In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

journal_title：International journal of biological sciences

authors： Yao W,Shen Z,Ding G

更新日期：2013-11-05 00:00:00

abstract：:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

journal_title：International journal of biological sciences

authors： Tian J,Casella G,Zhang Y,Rostami A,Li X

更新日期：2020-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition in plants and animals. At present there is relatively little information regarding the role of miRNAs in the response to drought stress in maize. In this study, ...

journal_title：International journal of biological sciences

authors： Sheng L,Chai W,Gong X,Zhou L,Cai R,Li X,Zhao Y,Jiang H,Cheng B

更新日期：2015-05-22 00:00:00

abstract：:The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

journal_title：International journal of biological sciences

authors： Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

更新日期：2013-05-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-beta signaling on tumor initiation and progression are cell-specifi...

journal_title：International journal of biological sciences

authors： Yang G,Yang X

更新日期：2010-01-01 00:00:00

abstract：:Collagen XXIV (Col24α1) is a recently discovered fibrillar collagen. It is known that mouse Col24α1 is predominantly expressed in the forming skeleton of the mouse embryo, as well as in the trabecular bone and periosteum of the newborn mouse. However, the role and mechanism of Col24α1 in osteoblast differentiation and...

journal_title：International journal of biological sciences

authors： Wang W,Olson D,Liang G,Franceschi RT,Li C,Wang B,Wang SS,Yang S

更新日期：2012-01-01 00:00:00

abstract：:N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases...

journal_title：International journal of biological sciences

authors： Zhu ZM,Huo FC,Pei DS

更新日期：2020-04-15 00:00:00

abstract：:Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligome...

journal_title：International journal of biological sciences

authors： Li T,Liu J,Cai H,Wang B,Feng Y,Liu J

更新日期：2018-04-30 00:00:00

abstract：:Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

journal_title：International journal of biological sciences

authors： Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

更新日期：2020-01-01 00:00:00

abstract：:Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide. Glycosphingolipids (GSLs) are involved in virus infection by regulating various steps of viral-host interaction. However, the distinct role of GSLs during DENV infection remains unclear. In this study, we used mouse melano...

journal_title：International journal of biological sciences

authors： Wang K,Wang J,Sun T,Bian G,Pan W,Feng T,Wang P,Li Y,Dai J

更新日期：2016-05-25 00:00:00

abstract：:As one of the most ominous malignancies, hepatocellular carcinoma (HCC) is frequently diagnosed at an advanced stage, owing to its aggressive invasion and metastatic spread. Emerging evidence has demonstrated that Rictor, as a unique component of the mTORC2, plays a role in cell migration, as it is dysregulated in var...

journal_title：International journal of biological sciences

authors： Dong X,Feng M,Yang H,Liu H,Guo H,Gao X,Liu Y,Liu R,Zhang N,Chen R,Kong R

更新日期：2020-09-01 00:00:00

abstract：:Proteomic profiling of the pectoralis muscle of Thai indigenous chickens during growth period was analyzed using two-dimensional gel electrophoresis (2-DE) and matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF/MS). A total of 259, 161, 120 and 107 protein spots were found to be ex...

journal_title：International journal of biological sciences

authors： Teltathum T,Mekchay S

更新日期：2009-10-28 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a tumor subtype with aggressive behavior and poor clinical outcome for lacking effective therapies. Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness...

journal_title：International journal of biological sciences

authors： Yang F,Cao L,Sun Z,Jin J,Fang H,Zhang W,Guan X

更新日期：2016-12-07 00:00:00

abstract：:Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

journal_title：International journal of biological sciences

authors： Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

更新日期：2014-03-10 00:00:00