Abstract:
:In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation well in high hydraulic permeability (k p) condition (k p ≥1.0×10(-8) m(2) in our numerical simulation), and it is an approximation to Darcy model in low k p condition (k p ≤5.0×10(-12) m(2) in our numerical simulation), we used the Brinkman model to simulate the interstitial fluid flow in the ligament where k p is approximately 1.0×10(-16) m(2). It shows k p and anisotropic property have a little effect on the flow field, but have a great effect on the shear stress on the membrane of interstitial cells (τ cell). There is a linear relationship between τ cell and , when k p =1.0×10(-16) m(2) and the maximum τ cell (τ cell,max) is approximately 10 Pa. The anisotropic property will affect τ cell's distribution on the cell surface. When k x/k y>1, low τ cell dominates the cell, while when k x/k y<1, high τ cell dominants the cell.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Yao W,Shen Z,Ding Gdoi
10.7150/ijbs.7242subject
Has Abstractpub_date
2013-11-05 00:00:00pages
1050-6issue
10issn
1449-2288pii
ijbsv09p1050journal_volume
9pub_type
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