Pathological Characterization Of IFNAR(-/-) Mice Infected With Bluetongue Virus Serotype 4.

abstract：:Prostate cancer (PCa) remains the most prevalent malignancy among males in the western world. Though hormonal therapies through chemical or surgical castration have been proposed many years ago, heretofore, such mainstay for the treatment on advanced PCa has not fundamentally changed. These therapeutic responses are t...

journal_title：International journal of biological sciences

authors： Zhang W,Meng Y,Liu N,Wen XF,Yang T

更新日期：2015-08-01 00:00:00

abstract：:Farrerol has been shown to have antioxidative potential via Nrf2 activation, which in turn is involved in the prevention of hepatotoxicity. The purpose of the current study was to explore the protective effect of farrerol against acetaminophen-induced hepatotoxicity and its underlying mechanisms. Mice were used to eva...

journal_title：International journal of biological sciences

authors： Wang L,Wei W,Xiao Q,Yang H,Ci X

更新日期：2019-01-29 00:00:00

abstract：:Carbon monoxide (CO) is a vasoactive molecule that is generated by vascular cells as a byproduct of heme catabolism and it plays an important physiological role in circulation system. In order to investigate whether exogenous CO can mediate the growth and proliferation of vascular cells, in this study, we used 250 par...

journal_title：International journal of biological sciences

authors： Li Y,Wang H,Yang B,Yang J,Ruan X,Yang Y,Wakeland EK,Li Q,Fang X

更新日期：2012-01-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by motor disorders and the destruction of dopaminergic neurons in the substantia nigra pars compacta. In addition to motor disability, many patients with PD present a spectrum of clinical symptoms, including cognitive decline, psychiatric alterations, loss of smell and bladder...

journal_title：International journal of biological sciences

authors： Pisa D,Alonso R,Carrasco L

更新日期：2020-02-10 00:00:00

abstract：:A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

journal_title：International journal of biological sciences

authors： Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

更新日期：2018-01-01 00:00:00

abstract：:Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for the prevention and treatment of inflammatory bone los...

journal_title：International journal of biological sciences

authors： Kwak SC,Baek JM,Lee CH,Yoon KH,Lee MS,Kim JY

更新日期：2019-09-07 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a tumor subtype with aggressive behavior and poor clinical outcome for lacking effective therapies. Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness...

journal_title：International journal of biological sciences

authors： Yang F,Cao L,Sun Z,Jin J,Fang H,Zhang W,Guan X

更新日期：2016-12-07 00:00:00

abstract：:Interleukin-8 (IL-8) is a common inflammatory factor, which involves in various non-specific pathological processes of inflammation. It has been found that increased endothelial permeability accompanied with high expression of IL-8 at site of injured endothelium and atherosclerotic plaque at early stages, suggesting t...

journal_title：International journal of biological sciences

authors： Yu H,Huang X,Ma Y,Gao M,Wang O,Gao T,Shen Y,Liu X

更新日期：2013-09-23 00:00:00

abstract：:MiR-216a-5p has opposite effects on tumorigenesis and progression in the context of different tumors, acting as either a tumor suppressor or an oncogene. However, the expression and function of miR-216a-5p in pancreatic cancer (PC) is not well characterized. In this study, we found miR-216a-5p was significantly downre...

journal_title：International journal of biological sciences

authors： Zhang J,Gao S,Zhang Y,Yi H,Xu M,Xu J,Liu H,Ding Z,He H,Wang H,Hao Z,Sun L,Liu Y,Wei F

更新日期：2020-07-19 00:00:00

abstract：:Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...

journal_title：International journal of biological sciences

authors： Ji L,Chauhan A,Chauhan V

更新日期：2012-01-01 00:00:00

abstract：:Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human...

journal_title：International journal of biological sciences

authors： Huang A,Dong J,Li S,Wang C,Ding H,Li H,Su X,Ge X,Sun L,Bai C,Shen X,Fang T,Li J,Shao N

更新日期：2015-06-11 00:00:00

abstract：:Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...

journal_title：International journal of biological sciences

authors： Rao F,Wang T,Li M,Li Z,Hong N,Zhao H,Yan Y,Lu W,Chen T,Wang W,Lim M,Yuan Y,Liu L,Zeng L,Wei Q,Guan G,Li C,Hong Y

更新日期：2011-04-15 00:00:00

abstract：:Cirrhosis is the final outcome of liver fibrosis. Kupffer cell-mediated hepatic inflammation is considered to aggravate liver injury and fibrosis. Alternatively-activated macrophages are able to control chronic inflammatory events and trigger wound healing processes. Nevertheless, the role of alternative Kupffer cell ...

journal_title：International journal of biological sciences

authors： López-Navarrete G,Ramos-Martínez E,Suárez-Álvarez K,Aguirre-García J,Ledezma-Soto Y,León-Cabrera S,Gudiño-Zayas M,Guzmán C,Gutiérrez-Reyes G,Hernández-Ruíz J,Camacho-Arroyo I,Robles-Díaz G,Kershenobich D,Terrazas LI,Escobedo

更新日期：2011-01-01 00:00:00

abstract：:After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...

journal_title：International journal of biological sciences

authors： Zheng B,Zhou Y,Zhang H,Yang G,Hong Z,Han D,Wang Q,He Z,Liu Y,Wu F,Zhang X,Tong S,Xu H,Xiao J

更新日期：2017-11-27 00:00:00

abstract：:Our previous studies indicated that phosphoinositide specific phospholipase Cγ1 (PLCγ1) was involved in autophagy induction in colon and hepatic carcinoma cells. However, whether and how PLCγ1 regulation in human lung adenocarcinoma is linked to autophagy remains unclear. Here, we assessed the protein expression of PL...

journal_title：International journal of biological sciences

authors： Lu X,Fu H,Chen R,Wang Y,Zhan Y,Song G,Hu T,Xia C,Tian X,Zhang B

更新日期：2020-02-21 00:00:00

abstract：:Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide. Glycosphingolipids (GSLs) are involved in virus infection by regulating various steps of viral-host interaction. However, the distinct role of GSLs during DENV infection remains unclear. In this study, we used mouse melano...

journal_title：International journal of biological sciences

authors： Wang K,Wang J,Sun T,Bian G,Pan W,Feng T,Wang P,Li Y,Dai J

更新日期：2016-05-25 00:00:00

abstract：:Thymosin alpha 1 (Tα1) has immunomodulatory and anti-tumor effects in patients and has been commercialized in worldwide. An innovative technique is therefore impending to achieve high-yield expression and purification of Tα1 to meet the increasing requirements for clinical applications. Tα1 can enhance T cells, dendri...

journal_title：International journal of biological sciences

authors： Li W,Song L,Wu S,Xue X,Zhang L,He L,Han W,Wang Q,Ling R,Zhang W,Yan Z,Zhang Y

更新日期：2011-01-01 00:00:00

abstract：:Pancreatic cancer (PC) is one of the most lethal diseases, characterized by early metastasis and high mortality. Subunits of the SWI/SNF complex have been identified in many studies as the regulators of tumor progression, but the role of SMARCAD1, one member of the SWI/SNF family, in pancreatic cancer has not been elu...

journal_title：International journal of biological sciences

authors： Liu F,Xia Z,Zhang M,Ding J,Feng Y,Wu J,Dong Y,Gao W,Han Z,Liu Y,Yao Y,Li D

更新日期：2019-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the prognostic prediction challenging. Ferroptosis, an iron-dependent form of regulated cell death, can be induced by sorafenib. However, the prognostic value of ferroptosis-related genes in HCC remains to be further elucidated. In this stud...

journal_title：International journal of biological sciences

authors： Liang JY,Wang DS,Lin HC,Chen XX,Yang H,Zheng Y,Li YH

更新日期：2020-07-06 00:00:00

abstract：:Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...

journal_title：International journal of biological sciences

authors： Xiao Q,Xia JH,Zhang XJ,Li Z,Wang Y,Zhou L,Gui JF

更新日期：2014-06-24 00:00:00

abstract：:Lead (Pb) is a well-known neurotoxicant and a risk factor for neurologic disorders. The blood brain barrier (BBB) plays an important role in the maintenance of optimal brain function. BBB is a target of Pb, and studies have shown that Pb induced barrier loss and decreased the expression of tight junction proteins, but...

journal_title：International journal of biological sciences

authors： Liu X,Su P,Meng S,Aschner M,Cao Y,Luo W,Zheng G,Liu M

更新日期：2017-10-31 00:00:00

abstract：:The cephalochordate amphioxus occupies a central place in evolutionary thoughts to the origin of Vertebrates. With a prototypical vertebrate-like body plan and a preduplicative genome, the friendly lancelet seems to be in morphological and genetic motionless since its separation from the major branch of evolution that...

journal_title：International journal of biological sciences

authors： Garcia-Fernàndez J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Increasing evidences suggest that innate immunity is involved in cerebral ischemia-reperfusion (I/R) injury, but the liable innate immune receptors have not been completely elucidated. Here, we explored the role of the nucleotide-binding oligomerization domain (NOD)2, a member of the cytosolic NOD-like recep...

journal_title：International journal of biological sciences

authors： Liu H,Wei X,Kong L,Liu X,Cheng L,Yan S,Zhang X,Chen L

更新日期：2015-03-25 00:00:00

abstract：:During the immune response, neutrophils display localized mechanical events by interacting with their environment through the micro-vascular transit, trans-endothelial, and trans-epithelial migration. Nano-mechanical studies of human neutrophils on localized nano-domains could provide the essential information for und...

journal_title：International journal of biological sciences

authors： Lee YJ,Patel D,Park S

更新日期：2011-01-20 00:00:00

abstract：:Capsaicin is the major pungent ingredient in red peppers which is world widely consumed. Except its potent pain relieving efficacy as reported, capsaicin also exerted its antitumor activity in several tumor models. Here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells vi...

journal_title：International journal of biological sciences

authors： Jin J,Lin G,Huang H,Xu D,Yu H,Ma X,Zhu L,Ma D,Jiang H

更新日期：2014-02-21 00:00:00

abstract：:The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

journal_title：International journal of biological sciences

authors： Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

更新日期：2019-07-25 00:00:00

abstract：:Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and ...

journal_title：International journal of biological sciences

authors： Wang Y,Wang J,Deng Z,Jin J,Jiang H,Meng J,Xu H,Zhao J,Sun G,Qian H

更新日期：2017-09-05 00:00:00

abstract：:Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in glioma. Expressions of RRM2 are higher in glioma tissues evidenced by TCGA data, western blot and immunohistoche...

journal_title：International journal of biological sciences

authors： Sun H,Yang B,Zhang H,Song J,Zhang Y,Xing J,Yang Z,Wei C,Xu T,Yu Z,Xu Z,Hou M,Ji M,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling pathways. FAK is overexpressed and/or activated in many types of human tumors, in which it promotes cell adhesion, survival, migration and invasion. In addition to FAK's ability ...

journal_title：International journal of biological sciences

authors： Dwyer SF,Gao L,Gelman IH

更新日期：2015-02-17 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00