Inhibition of mTOR signaling Confers Protection against Cerebral Ischemic Injury in Acute Hyperglycemic Rats.

abstract：:Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...

journal_title：International journal of biological sciences

authors： Zhou Q,Li M,Wang X,Li Q,Wang T,Zhu Q,Zhou X,Wang X,Gao X,Li X

更新日期：2012-01-01 00:00:00

abstract：:The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

journal_title：International journal of biological sciences

authors： Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

更新日期：2013-05-15 00:00:00

abstract：:Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...

journal_title：International journal of biological sciences

authors： Li H,Zhang X,Qi X,Zhu X,Cheng L

更新日期：2019-01-01 00:00:00

abstract：:Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and ...

journal_title：International journal of biological sciences

authors： Wang Y,Wang J,Deng Z,Jin J,Jiang H,Meng J,Xu H,Zhao J,Sun G,Qian H

更新日期：2017-09-05 00:00:00

abstract：:In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

journal_title：International journal of biological sciences

authors： Yao W,Shen Z,Ding G

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Oridonin (ORI) could inhibit the proliferation and induce apoptosis in various cancer cell lines. However, the mechanism is not fully understood. METHODS:Human prostate cancer (HPC) cells were cultured in vitro and cell viability was detected by the CCK-8 assay. The ultrastructure changes were observed unde...

journal_title：International journal of biological sciences

authors： Li X,Li X,Wang J,Ye Z,Li JC

更新日期：2012-01-01 00:00:00

abstract：:Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is known to modulate cell proliferation, differentiation, and migration, all of which are features of ...

journal_title：International journal of biological sciences

authors： Zhang Z,Zhang J,Miao L,Liu K,Yang S,Pan C,Jiao B

更新日期：2012-01-01 00:00:00

abstract：:Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...

journal_title：International journal of biological sciences

authors： Xiao Q,Xia JH,Zhang XJ,Li Z,Wang Y,Zhou L,Gui JF

更新日期：2014-06-24 00:00:00

abstract：:Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

journal_title：International journal of biological sciences

authors： Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

更新日期：2014-03-10 00:00:00

abstract：:MicroRNA-370 (miR-370) has been observed to act as a tumor suppressor through the targeting of different proteins in a variety of tumors. Our previous study indicated that miR-370 was able to target forkhead box protein M1 (FOXM1) to inhibit cell growth and metastasis in human osteosarcoma cells. In this study, we rep...

journal_title：International journal of biological sciences

authors： Zhang W,Duan N,Zhang Q,Song T,Li Z,Zhang C,Chen X,Wang K

更新日期：2017-04-10 00:00:00

abstract：:Osteosarcoma (OS) is considered the most common type of primary malignant bone tumor, which has an urgent need for more effective treatment. Recently, chitinase 3 like 1 (Chi3L1) expression has been found in a variety of cancer cells. However it is not known whether Chi3L1 regulates the STAT3 pathway in OS cells. Here...

journal_title：International journal of biological sciences

authors： Park KR,Yun HM,Hong JT

更新日期：2020-01-01 00:00:00

abstract：:Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

journal_title：International journal of biological sciences

authors： Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

更新日期：2019-11-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling pathways. FAK is overexpressed and/or activated in many types of human tumors, in which it promotes cell adhesion, survival, migration and invasion. In addition to FAK's ability ...

journal_title：International journal of biological sciences

authors： Dwyer SF,Gao L,Gelman IH

更新日期：2015-02-17 00:00:00

abstract：:Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative approaches in muscle regeneration. The aim of the study was to demonstrate cryogel scaffold potential in the field of ...

journal_title：International journal of biological sciences

authors： Singh D,Nayak V,Kumar A

更新日期：2010-07-03 00:00:00

abstract：:Two assumptions underlie current models of the geographical ranges of perennial plant species: 1. current ranges are in equilibrium with the prevailing climate, and 2. changes are attributable to changes in macroclimatic factors, including tolerance of winter cold, the duration of the growing season, and water stress ...

journal_title：International journal of biological sciences

authors： Kramer K,Bijlsma RJ,Hickler T,Thuiller W

更新日期：2012-01-01 00:00:00

abstract：:Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...

journal_title：International journal of biological sciences

authors： Zhao W,Ma L,Cai C,Gong X

更新日期：2019-06-02 00:00:00

abstract：:Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

journal_title：International journal of biological sciences

authors： Zhang Q,Dong J,Yu Z

更新日期：2020-08-13 00:00:00

abstract：:Bluetongue virus (BTV) replicates in lymphoid tissues where infected mononuclear leukocytes secrete proinflammatory and vasoactive mediators that can contribute to bluetongue (BT) pathogenesis. Using the well-characterized IFNAR(-/-) mice animal model, we have now studied the histopathology and dynamics of leukocyte p...

journal_title：International journal of biological sciences

authors： Marín-López A,Bermúdez R,Calvo-Pinilla E,Moreno S,Brun A,Ortego J

更新日期：2016-11-24 00:00:00

abstract：:CKLF-like MARVEL transmembrane domain-containing member (CMTM) is a new gene family first cloned and reported in 2001. The CMTM family consists of nine members including CKLF and CMTM1-CMTM8, which are located on different chromosomes. Besides exhibiting extensive chemotactic activity, the CMTM family plays an importa...

journal_title：International journal of biological sciences

authors： Wu K,Li X,Gu H,Yang Q,Liu Y,Wang L

更新日期：2019-09-07 00:00:00

abstract：:Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecule...

journal_title：International journal of biological sciences

authors： Tian J,Casella G,Zhang Y,Rostami A,Li X

更新日期：2020-01-01 00:00:00

abstract：:We collected clinical data from 308 prostate cancer (PCa) patients to investigate the clinical characteristics and independent risk factors of bone metastasis (BM) and to establish a prediction model for BM of PCa and determine the necessity of bone scans. Univariate and multivariate analyses were performed based on a...

journal_title：International journal of biological sciences

authors： Chen S,Wang L,Qian K,Jiang W,Deng H,Zhou Q,Wang G,Liu X,Wu CL,Xiao Y,Wang X

更新日期：2019-01-01 00:00:00

abstract：:Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). The receptors AgOR1 and AgOR2, as well as the binding protein AgOBP1, have been implicated in the recognition of human host odors. ...

journal_title：International journal of biological sciences

authors： Schymura D,Forstner M,Schultze A,Kröber T,Swevers L,Iatrou K,Krieger J

更新日期：2010-10-08 00:00:00

abstract：:Despite years of research into bone formation, the mechanisms by which transcription factors specify growth plate development and trabecular bone formation remain unclear and the role of hypertrophic chondrocytes in trabeculae morphogenesis is controversial. To study the role of Core binding factor beta (Cbfβ) in post...

journal_title：International journal of biological sciences

authors： Wu M,Li YP,Zhu G,Lu Y,Wang Y,Jules J,McConnell M,Serra R,Shao JZ,Chen W

更新日期：2014-07-29 00:00:00

abstract：:Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in...

journal_title：International journal of biological sciences

authors： Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PC

更新日期：2020-01-01 00:00:00

abstract：:Breast cancer (BC) is the most common cause of death in women throughout the world. Although microRNAs (miRNAs) have been identified as novel regulators in carcinogenesis, there are still abundant hidden treasure needed to be excavated. In the present study, we found that miR-519d expression was remarkably decreased i...

journal_title：International journal of biological sciences

authors： Chu C,Liu X,Bai X,Zhao T,Wang M,Xu R,Li M,Hu Y,Li W,Yang L,Qin Y,Yang M,Yan C,Zhang Y

更新日期：2018-02-09 00:00:00

abstract：:N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases...

journal_title：International journal of biological sciences

authors： Zhu ZM,Huo FC,Pei DS

更新日期：2020-04-15 00:00:00

abstract：:The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

journal_title：International journal of biological sciences

authors： Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

更新日期：2019-07-25 00:00:00

abstract：:Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

journal_title：International journal of biological sciences

authors： Kumari A,Pal Pathak D,Asthana S

更新日期：2020-06-14 00:00:00

abstract：:Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed in...

journal_title：International journal of biological sciences

authors： Wang C,Zhao L,Lu S

更新日期：2015-02-05 00:00:00

abstract：:Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...

journal_title：International journal of biological sciences

authors： Wang H,Shi L,Liang T,Wang B,Wu W,Su G,Wei J,Li P,Huang R

更新日期：2017-03-11 00:00:00