Interleukin-11 promotes the progress of gastric carcinoma via abnormally expressed versican.

Abstract:

:Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is known to modulate cell proliferation, differentiation, and migration, all of which are features of the invasion and metastasis of cancer; versican is also known to favour the homeostasis of the ECM. Interleukin-11 (IL-11) is an important cytokine that exhibits a wide variety of biological effects in gastric cancer development. Here, we analysed the expression of versican isoforms and found that the major isoforms expressed by both gastric carcinoma tissue and gastric cell lines were V0 and V1, and V1 was significantly higher in gastric carcinoma tissue. The treatment of the gastric cell lines AGS and MKN45 with rhIL-11 resulted in a significant increase in the expression of V0 and V1. Exogenous IL-11 increased migration in AGS and MKN45 cells, whereas these effects were reversed when the expression of V0 and V1 were abolished by siRNA targeting versican V0/V1. Collectively, these findings suggest that the abnormally expressed versican and its isoforms participate, at least in part, in the progress of gastric carcinoma triggered by IL-11.

journal_name

Int J Biol Sci

authors

Zhang Z,Zhang J,Miao L,Liu K,Yang S,Pan C,Jiao B

doi

10.7150/ijbs.3579

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

383-93

issue

3

issn

1449-2288

pii

ijbsv08p0383

journal_volume

8

pub_type

杂志文章
  • Dentinal mineralization is not limited in the mineralization front but occurs along with the entire odontoblast process.

    abstract::The mineralization-front theory is historically rooted in mineralization research fields for many decades. This theory is widely used to describe mineralization events in both osteogenesis and dentinogenesis. However, this model does not provide enough evidence to explain how minerals are propagated from the pulp-end ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.25712

    authors: Li C,Jing Y,Wang K,Ren Y,Liu X,Wang X,Wang Z,Zhao H,Feng JQ

    更新日期:2018-04-30 00:00:00

  • Enhancement of oxaliplatin-induced colon cancer cell apoptosis by alantolactone, a natural product inducer of ROS.

    abstract::Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.35265

    authors: Cao P,Xia Y,He W,Zhang T,Hong L,Zheng P,Shen X,Liang G,Cui R,Zou P

    更新日期:2019-06-04 00:00:00

  • Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells.

    abstract::Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.11943

    authors: Huang A,Dong J,Li S,Wang C,Ding H,Li H,Su X,Ge X,Sun L,Bai C,Shen X,Fang T,Li J,Shao N

    更新日期:2015-06-11 00:00:00

  • Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages.

    abstract::Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.34211

    authors: Zhao W,Ma L,Cai C,Gong X

    更新日期:2019-06-02 00:00:00

  • MiR-696 Regulates C2C12 Cell Proliferation and Differentiation by Targeting CNTFRα.

    abstract::Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.17508

    authors: Wang H,Shi L,Liang T,Wang B,Wu W,Su G,Wei J,Li P,Huang R

    更新日期:2017-03-11 00:00:00

  • FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts.

    abstract::Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.1114

    authors: Lin X,Zhang Y,Liu L,McKeehan WL,Shen Y,Song S,Wang F

    更新日期:2011-01-01 00:00:00

  • Pleiotropic use of Statins as non-lipid-lowering drugs.

    abstract::Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.42965

    authors: Zhang Q,Dong J,Yu Z

    更新日期:2020-08-13 00:00:00

  • An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer.

    abstract::Epithelial-to-mesenchymal transition (EMT) is a key process in EGFR-TKI resistance but the detailed mechanism is largely unknown. We aim to evaluate the role of interleukin-6 (IL-6) and insulin-like growth factor-1 receptor (IGR-1R) in EMT in non-small cell lung cancer (NSCLC). We used IL-6 to induce EMT in EGFR-TKI s...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31999

    authors: Zheng X,Lu G,Yao Y,Gu W

    更新日期:2019-07-20 00:00:00

  • Exosomal Metastasis‑Associated Lung Adenocarcinoma Transcript 1 Promotes Angiogenesis and Predicts Poor Prognosis in Epithelial Ovarian Cancer.

    abstract::Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular cargos, including long noncoding RNAs (lncRNAs). Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a well-known lncRNA associated with cancer angiogenesis and metastasis. However, the presence of MALAT1 in exoso...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.28048

    authors: Qiu JJ,Lin XJ,Tang XY,Zheng TT,Lin YY,Hua KQ

    更新日期:2018-11-01 00:00:00

  • Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis.

    abstract::Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.26045

    authors: Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

    更新日期:2018-07-27 00:00:00

  • Is sodium current present in human sinoatrial node cells?

    abstract::Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform pa...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.5.201

    authors: Verkerk AO,Wilders R,van Borren MM,Tan HL

    更新日期:2009-01-01 00:00:00

  • A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment.

    abstract::Small synthetic compounds have been implicated in treatment of human cancers. We have synthesized a small compound, BPR1K0609S1 (hereafter, BP), which inhibits Aurora-A kinase. In the present study, we studied the mechanism of BP suppression of tumorigenesis induced by Aurora-A. Given our previous results that inactiv...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.5806

    authors: Shionome Y,Lin WH,Shiao HY,Hsieh HP,Hsu JT,Ouchi T

    更新日期:2013-04-29 00:00:00

  • The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium.

    abstract::Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.24681

    authors: Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

    更新日期:2018-04-05 00:00:00

  • Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.

    abstract::The vertebrate body plan externally is largely symmetrical across the midline but internal organs develop asymmetrically. The biological basis of asymmetric organ development has been investigated extensively for years, although the proposed mechanisms remain controversial. By comparison, the biological origin of exte...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.9886

    authors: Klar AJ

    更新日期:2014-09-10 00:00:00

  • Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.

    abstract::Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31781

    authors: Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

    更新日期:2019-11-01 00:00:00

  • Circ-100290 Positively Regulates Angiogenesis Induced by Conditioned Medium of Human Amnion-Derived Mesenchymal Stem Cells Through miR-449a/eNOS and miR-449a/VEGFA Axes.

    abstract::The powerful pro-angiogenic capacity of human amnion-derived mesenchymal stem cells (hAMSCs) could be a valuable therapeutic angiogenesis strategy for bone regeneration. However, the molecular mechanisms underlying this process remain largely unknown. Herein, we report upregulated expression of circular RNA 100290 (ci...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.39895

    authors: Tang Z,Wu X,Hu L,Xiao Y,Tan J,Zuo S,Shen M,Yuan X

    更新日期:2020-05-18 00:00:00

  • Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells.

    abstract::Protein phosphatase 2A (PP2A) is a major protein phosphatase with important cell functions. Known and utilized as a potent inhibitor of PP2A, microcystin-LR (MCLR) targets PP2A as a core element that affects numerous cellular mechanisms. But apart from direct inhibition, the exact effect of MCLR on PP2A in cell is lar...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.740

    authors: Li T,Huang P,Liang J,Fu W,Guo Z,Xu L

    更新日期:2011-01-01 00:00:00

  • Melatonin Stimulates STAR Expression and Progesterone Production via Activation of the PI3K/AKT Pathway in Bovine Theca Cells.

    abstract::Melatonin is present in mammalian follicular fluid and plays an important role in regulating steroidogenesis in follicular cells. In this study, we report the effect of melatonin on steroidogenesis in the theca interna (TI) in small bovine follicles and theca cells (TCs) cultured in vitro. Treatment with melatonin sig...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.27912

    authors: Wang X,Meng K,He Y,Wang H,Zhang Y,Quan F

    更新日期:2019-01-01 00:00:00

  • Enhanced cytotoxicity for colon 26 cells using doxorubicin-loaded sorbitan monooleate (Span 80) vesicles.

    abstract::Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs) were thereafter add...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.5453

    authors: Hayashi K,Tatsui T,Shimanouchi T,Umakoshi H

    更新日期:2013-01-01 00:00:00

  • Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs.

    abstract::Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer,...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.33710

    authors: Wang M,Jiang S,Zhou L,Yu F,Ding H,Li P,Zhou M,Wang K

    更新日期:2019-05-07 00:00:00

  • Effects of diosgenin on myometrial matrix metalloproteinase-2 and -9 activity and expression in ovariectomized rats.

    abstract::Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.837

    authors: Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

    更新日期:2011-01-01 00:00:00

  • Vitamin K2 Prevents Glucocorticoid-induced Osteonecrosis of the Femoral Head in Rats.

    abstract::Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head (ONFH), and vitamin K2 (VK2) has been shown to play an important and beneficial role in bone metabolism. In this study, we hypothesized that VK2 could decrease the incidence of glucocorticoid-induced ONFH in a ra...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.13269

    authors: Zhang YL,Yin JH,Ding H,Zhang W,Zhang CQ,Gao YS

    更新日期:2016-01-28 00:00:00

  • The silencing of RECK gene is associated with promoter hypermethylation and poor survival in hepatocellular carcinoma.

    abstract:BACKGROUND:To evaluate the promoter methylation status of RECK gene and mRNA expression in patients with hepatocellular carcinoma (HCC). METHODS:We analyzed RECK methylation by MSP, and RECK mRNA by real-time PCR in 74 HCC. The liver cell lines (7721, Chang and Hep-G2) were treated with 5-Aza-CdR and TSA. RESULTS:REC...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.4038

    authors: Zhang C,Ling Y,Zhang C,Xu Y,Gao L,Li R,Zhu J,Fan L,Wei L

    更新日期:2012-01-01 00:00:00

  • Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity.

    abstract::Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.37550

    authors: Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

    更新日期:2020-01-01 00:00:00

  • Type-IV antifreeze proteins are essential for epiboly and convergence in gastrulation of zebrafish embryos.

    abstract::Many organisms in extremely cold environments such as the Antarctic Pole have evolved antifreeze molecules to prevent ice formation. There are four types of antifreeze proteins (AFPs). Type-IV antifreeze proteins (AFP4s) are present also in certain temperate and even tropical fish, which has raised a question as to wh...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.9126

    authors: Xiao Q,Xia JH,Zhang XJ,Li Z,Wang Y,Zhou L,Gui JF

    更新日期:2014-06-24 00:00:00

  • Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway.

    abstract::Evodiamine has therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and evodiamine enhanced antitumor efficacy in pancreatic cancer. In vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.8.1

    authors: Wei WT,Chen H,Wang ZH,Ni ZL,Liu HB,Tong HF,Guo HC,Liu DL,Lin SZ

    更新日期:2012-01-01 00:00:00

  • Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles.

    abstract::Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (c...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.39212

    authors: Zhang C,Ma L,Niu Y,Wang Z,Xu X,Li Y,Yu Y

    更新日期:2020-01-16 00:00:00

  • The role of TGF-β/SMAD4 signaling in cancer.

    abstract::Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.23230

    authors: Zhao M,Mishra L,Deng CX

    更新日期:2018-01-12 00:00:00

  • p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos.

    abstract::The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31451

    authors: Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

    更新日期:2019-07-25 00:00:00

  • Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice.

    abstract::Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.297

    authors: Zhao L,Zhou C,Zhang J,Gao F,Li B,Chuai Y,Liu C,Cai J

    更新日期:2011-03-25 00:00:00