Abstract:
:Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. The underlying mechanisms are the focus of intensive investigation for development of more effective treatment. Mounting evidence from both clinical and basic research has demonstrated that the activity of the androgen receptor (AR) is still required for castration-resistant prostate cancer. Multiple mechanisms by which AR is re-activated under androgen-depleted conditions may be involved in the development of castration resistance. The recent identification of AR splicing variants may add another layer of complexity in AR biology. The present review summarizes recent progress in study of AR splicing variants in prostate cancer.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Guo Z,Qiu Ydoi
10.7150/ijbs.7.815subject
Has Abstractpub_date
2011-01-01 00:00:00pages
815-22issue
6issn
1449-2288journal_volume
7pub_type
杂志文章,评审abstract::Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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更新日期:2018-10-03 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:International journal of biological sciences
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-01-12 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.3.420
更新日期:2007-10-25 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2016-01-28 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of biological sciences
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更新日期:2014-07-29 00:00:00
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更新日期:2020-03-12 00:00:00
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更新日期:2015-04-27 00:00:00
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journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.1027
更新日期:2011-01-01 00:00:00