The role of TGF-β/SMAD4 signaling in cancer.

Abstract:

:Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half of pancreatic duct adenocarcinoma, and varying degrees in many other types of cancers. In the past two decades, multiple studies have revealed that SMAD4 loss on its own does not initiate tumor formation, but can promote tumor progression initiated by other genes, such as KRAS activation in pancreatic duct adenocarcinoma and APC inactivation in colorectal cancer. In other cases, such as skin cancer, loss of SMAD4 plays an important initiating role by disrupting DNA damage response and repair mechanisms and enhance genomic instability, suggesting its distinct roles in different types of tumors. This review lists SMAD4 mutations in various types of cancer and summarizes recent advances on SMAD4 with focuses on the function, signaling pathway, and the possibility of SMAD4 as a prognostic indicator.

journal_name

Int J Biol Sci

authors

Zhao M,Mishra L,Deng CX

doi

10.7150/ijbs.23230

subject

Has Abstract

pub_date

2018-01-12 00:00:00

pages

111-123

issue

2

issn

1449-2288

pii

ijbsv14p0111

journal_volume

14

pub_type

杂志文章,评审
  • SASH1 promotes melanin synthesis and migration via suppression of TGF-β1 secretion in melanocytes resulting in pathologic hyperpigmentation.

    abstract::Dyschromatosis universalis hereditaria (DUH) is an autosomal dominant pigmentary genodermatosis characterized by the presence of patches of hyperpigmentation and hypopigmented macules distributed over the body, with most cases reported in Asia. DUH is a heterogeneous disease and a small portion of patients carry the A...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.38415

    authors: Cui H,Guo S,He H,Guo H,Zhang Y,Wang B

    更新日期:2020-02-10 00:00:00

  • Cestode antigens induce a tolerogenic-like phenotype and inhibit LPS inflammatory responses in human dendritic cells.

    abstract::Pathogens have developed strategies to modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their survival. DCs responses to helminths and their derivatives vary among different studies. Here we show that excretory/secretory products of the cestode Taenia crassi...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.1391

    authors: Terrazas CA,Sánchez-Muñoz F,Mejía-Domínguez AM,Amezcua-Guerra LM,Terrazas LI,Bojalil R,Gómez-García L

    更新日期:2011-01-01 00:00:00

  • Discovery of candidate genes for muscle traits based on GWAS supported by eQTL-analysis.

    abstract::Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.8134

    authors: Ponsuksili S,Murani E,Trakooljul N,Schwerin M,Wimmers K

    更新日期:2014-03-10 00:00:00

  • Seminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motility.

    abstract:OBJECTIVES:Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. We aimed to evaluate the relationship of MDA and GPx levels wit...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.2.23

    authors: Hsieh YY,Chang CC,Lin CS

    更新日期:2006-01-01 00:00:00

  • Functions of autophagy in pathological cardiac hypertrophy.

    abstract::Pathological cardiac hypertrophy is the response of heart to various biomechanical and physiopathological stimuli, such as aging, myocardial ischemia and hypertension. However, a long-term exposure to the stress makes heart progress to heart failure. Autophagy is a dynamic self-degradative process necessary for the ma...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.11883

    authors: Li Z,Wang J,Yang X

    更新日期:2015-04-27 00:00:00

  • Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.

    abstract::A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process inste...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.23165

    authors: Jing Y,Jing J,Wang K,Chan K,Harris SE,Hinton RJ,Feng JQ

    更新日期:2018-01-01 00:00:00

  • γδ T cells and their potential for immunotherapy.

    abstract::Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.7823

    authors: Wu YL,Ding YP,Tanaka Y,Shen LW,Wei CH,Minato N,Zhang W

    更新日期:2014-01-10 00:00:00

  • RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways.

    abstract::The evading apoptosis of tumor cells may result in chemotherapy resistance. Therefore, investigating what molecular events contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity. In this study, we foc...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.36829

    authors: Ji Y,Shen J,Li M,Zhu X,Wang Y,Ding J,Jiang S,Chen L,Wei W

    更新日期:2019-10-15 00:00:00

  • TRIM59 Is a Novel Marker of Poor Prognosis and Promotes Malignant Progression of Ovarian Cancer by Inducing Annexin A2 Expression.

    abstract::Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.28757

    authors: Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

    更新日期:2018-11-03 00:00:00

  • Fluorouracil selectively enriches stem-like leukemic cells in a leukemic cell line.

    abstract::Recent studies have reported that cancer stem cells (CSCs) could be isolated from solid cancer cell lines, in which the purity of CSCs was higher than that from tumor tissues. Separation of CSCs from leukemic cell lines was rarely reported. In this study, CD34(+)CD38(-)stem-like cell subsets in human KG-1a leukemic ce...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.6.419

    authors: Zhang L,Yang S,He YJ,Shao HY,Wang L,Chen H,Gao YJ,Qing FX,Chen XC,Zhao LY,Tan S

    更新日期:2010-08-03 00:00:00

  • Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.

    abstract::The vertebrate body plan externally is largely symmetrical across the midline but internal organs develop asymmetrically. The biological basis of asymmetric organ development has been investigated extensively for years, although the proposed mechanisms remain controversial. By comparison, the biological origin of exte...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.9886

    authors: Klar AJ

    更新日期:2014-09-10 00:00:00

  • The Significance of Ras Activity in Pancreatic Cancer Initiation.

    abstract::The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.15020

    authors: Logsdon CD,Lu W

    更新日期:2016-01-28 00:00:00

  • PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients.

    abstract::Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FLSs). FLSs were isol...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.16879

    authors: Fan L,Zong M,Gong R,He D,Li N,Sun LS,Ye Q,Yu S

    更新日期:2017-02-25 00:00:00

  • Bioavailability of heme iron in biscuit filling using piglets as an animal model for humans.

    abstract::The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.7150/ijbs.4.58

    authors: Quintero-Gutiérrez AG,González-Rosendo G,Sánchez-Muñoz J,Polo-Pozo J,Rodríguez-Jerez JJ

    更新日期:2008-02-18 00:00:00

  • p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos.

    abstract::The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.31451

    authors: Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

    更新日期:2019-07-25 00:00:00

  • Mesenchymal Stem Cells Promote Tumor Progression via Inducing Stroma Remodeling on Rabbit VX2 Bladder Tumor Model.

    abstract::Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.25200

    authors: Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

    更新日期:2018-06-03 00:00:00

  • Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity.

    abstract::Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.37550

    authors: Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

    更新日期:2020-01-01 00:00:00

  • Medaka tert produces multiple variants with differential expression during differentiation in vitro and in vivo.

    abstract::Embryonic stem (ES) cells have immortality for self-renewal and pluripotency. Differentiated human cells undergo replicative senescence. In human, the telomerase reverse transcriptase (Tert), namely the catalytic subunit of telomerase, exhibits differential expression to regulate telomerase activity governing cellular...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.426

    authors: Rao F,Wang T,Li M,Li Z,Hong N,Zhao H,Yan Y,Lu W,Chen T,Wang W,Lim M,Yuan Y,Liu L,Zeng L,Wei Q,Guan G,Li C,Hong Y

    更新日期:2011-04-15 00:00:00

  • Circulating and tumor-infiltrating Foxp3⁺ regulatory T cell subset in Chinese patients with extranodal NK/T cell lymphoma.

    abstract::Foxp3⁺ regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp3(+) subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENK...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.7.1027

    authors: Peng RJ,Huang ZF,Zhang YL,Yuan ZY,Xia Y,Jiang WQ,Zeng YX,Li J

    更新日期:2011-01-01 00:00:00

  • Pleiotropic use of Statins as non-lipid-lowering drugs.

    abstract::Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.42965

    authors: Zhang Q,Dong J,Yu Z

    更新日期:2020-08-13 00:00:00

  • Structural dynamics and epigenetic modifications of Hoxc loci along the anteroposterior body axis in developing mouse embryos.

    abstract::Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.4438

    authors: Min H,Lee JY,Kim MH

    更新日期:2012-01-01 00:00:00

  • The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium.

    abstract::Cell density has profound impacts on the cell culture practices of human pluripotent stem cells. The regulation of cell growth, cell death, pluripotency and differentiation converge at high density, but it is largely unknown how different regulatory mechanisms act at this stage. We use a chemically defined medium to s...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.24681

    authors: Liu W,Ren Z,Lu K,Song C,Cheung ECW,Zhou Z,Chen G

    更新日期:2018-04-05 00:00:00

  • Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis.

    abstract::Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-related death. Metastatic disease or the movement of cancer cells from one site to another requires dramatic remodeling of the cytoskeleton. The regulation of cancer cell migration is determined not only by biochemical factors in...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.7150/ijbs.44943

    authors: Li X,Wang J

    更新日期:2020-04-27 00:00:00

  • Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3K/AKT Signaling Pathway.

    abstract::Endoplasmic reticulum (ER) stress-induced neuronal apoptosis is a crucial pathological process of spinal cord injury (SCI). In our previous study, icariin (ICA) showed neuroprotective effects in SCI. However, the relationships between ER stress and ICA in SCI are unclear yet. Therefore, whether ICA could ameliorate SC...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.30348

    authors: Li H,Zhang X,Qi X,Zhu X,Cheng L

    更新日期:2019-01-01 00:00:00

  • Transarterial Chemoembolization: A Favorable Postoperative Management to Improve Prognosis of Hepatitis B Virus-associated Intrahepatic Cholangiocarcinoma after Surgical Resection.

    abstract::Background: There is no information regarding transarterial chemoembolization (TACE) as a postoperative management after hepatic resection for patients with hepatitis B virus (HBV)-associated intrahepatic cholangiocarcinoma (ICC). Methods: Forty-two patients with pathological confirmation of HBV-associated ICC were en...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.21149

    authors: Jeong S,Zheng B,Wang J,Chi J,Tong Y,Xia L,Xu N,Zhang J,Kong X,Gu J,Xia Q

    更新日期:2017-09-21 00:00:00

  • The effect of HMGA1 in LPS-induced Myocardial Inflammation.

    abstract::Aims: The High Mobility Group A1 (HMGA1) proteins, serving as a dynamic regulator of gene transcription and chromatin remodeling, play an influential part in the pathological process of a large number of cardiovascular diseases. However, the precise role of HMGA1 in sepsis induced cardiomyopathy (SIC) remains unintell...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.39947

    authors: Cai ZL,Shen B,Yuan Y,Liu C,Xie QW,Hu TT,Yao Q,Wu QQ,Tang QZ

    更新日期:2020-03-26 00:00:00

  • Identifying differentially expressed genes from cross-site integrated data based on relative expression orderings.

    abstract::It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.24548

    authors: Cai H,Li X,Li J,Liang Q,Zheng W,Guan Q,Guo Z,Wang X

    更新日期:2018-05-22 00:00:00

  • The gain of function of p53 mutant p53S in promoting tumorigenesis by cross-talking with H-RasV12.

    abstract::The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.4176

    authors: Jia S,Zhao L,Tang W,Luo Y

    更新日期:2012-01-01 00:00:00

  • Tyrosine sulfation of statherin.

    abstract::Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William et al. Arch Biochem Biophys 1997; 338: 90-96). In the present study we demonstrate the sulfation of a salivary secretory...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.3.237

    authors: Kasinathan C,Gandhi N,Ramaprasad P,Sundaram P,Ramasubbu N

    更新日期:2007-03-02 00:00:00

  • Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis.

    abstract::Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章

    doi:10.7150/ijbs.26045

    authors: Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

    更新日期:2018-07-27 00:00:00