The PI3K/AKT pathway in obesity and type 2 diabetes.

abstract：:Ovarian cancer is the fifth common cause of death in woman worldwide. The tripartite motif-containing (TRIM) proteins consist of more than 70 known protein members. Studies have showed that TRIM proteins are involved in cancer and play important roles in cancer cell proliferation, migration, adhesion and metastasis. R...

journal_title：International journal of biological sciences

authors： Wang Y,Zhou Z,Wang X,Zhang X,Chen Y,Bai J,Di W

更新日期：2018-11-03 00:00:00

abstract：:Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect neuronal cells against oxidative stress in neurodegenerative diseases. The present study was designed to examine whether CoQ10 was capable of protecting astrocytes from reactive oxygen species (ROS) mediated damage. For this purpose, ultraviole...

journal_title：International journal of biological sciences

authors： Jing L,He MT,Chang Y,Mehta SL,He QP,Zhang JZ,Li PA

更新日期：2015-01-01 00:00:00

abstract：:In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

journal_title：International journal of biological sciences

authors： Yao W,Shen Z,Ding G

更新日期：2013-11-05 00:00:00

abstract：:The objective of this study was to study the effect of diabetic hyperglycemia on astrocytes after forebrain ischemia. Streptozotocin (STZ)-injected hyperglycemic and vehicle-injected normoglycemic rats were subjected to 15 minutes of forebrain ischemia. The brains were harvested in sham-operated controls and in animal...

journal_title：International journal of biological sciences

authors： Jing L,Mai L,Zhang JZ,Wang JG,Chang Y,Dong JD,Guo FY,Li PA

更新日期：2013-09-25 00:00:00

abstract：:The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by both loss of function in inhibiting cell cycle progress and g...

journal_title：International journal of biological sciences

authors： Zhao J,Tian Y,Zhang H,Qu L,Chen Y,Liu Q,Luo Y,Wu X

更新日期：2019-07-25 00:00:00

abstract：:Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

journal_title：International journal of biological sciences

authors： Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

更新日期：2011-01-01 00:00:00

abstract：:To investigate the effects of Genistein on the osteogenic related gene expression profiles during osteoblastic differentiation of human bone marrow mesenchymal stem cell (hBMSC) cultures, the hBMSCs were cultured under osteogenic differentiation medium with the addition of Genistein (10(-8)∼10(-5) M) for 12 days. The ...

journal_title：International journal of biological sciences

authors： Dai J,Li Y,Zhou H,Chen J,Chen M,Xiao Z

更新日期：2013-11-21 00:00:00

abstract：:In order to find a blood host and to select appropriate oviposition sites female Anopheles gambiae mosquitoes rely on olfactory cues which are sensed by olfactory sensory neurons (OSNs) located within morphologically different sensilla hairs. While the sharp type trichoid sensilla are most abundant and intensely studi...

journal_title：International journal of biological sciences

authors： Schultze A,Breer H,Krieger J

更新日期：2014-03-22 00:00:00

abstract：:Thymosin alpha 1 (Tα1) has immunomodulatory and anti-tumor effects in patients and has been commercialized in worldwide. An innovative technique is therefore impending to achieve high-yield expression and purification of Tα1 to meet the increasing requirements for clinical applications. Tα1 can enhance T cells, dendri...

journal_title：International journal of biological sciences

authors： Li W,Song L,Wu S,Xue X,Zhang L,He L,Han W,Wang Q,Ling R,Zhang W,Yan Z,Zhang Y

更新日期：2011-01-01 00:00:00

abstract：:Cell-matrix interactions play critical roles in cell adhesion, tissue remodeling and cancer metastasis. Discoidin domain receptor 2 (DDR2) is a collagen receptor belonging to receptor tyrosine kinase (RTK) family. It is a powerful regulator of collagen deposition in the extracellular matrix (ECM). Although the oligome...

journal_title：International journal of biological sciences

authors： Li T,Liu J,Cai H,Wang B,Feng Y,Liu J

更新日期：2018-04-30 00:00:00

abstract：:With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivit...

journal_title：International journal of biological sciences

authors： Ma S,Miao H,Luo Y,Sun Y,Tian X,Wang F,You C,Peng S,Tang G,Yang C,Sun W,Li S,Mao Y,Xu J,Xiao Y,Gong Y,Quan H,Xie C

更新日期：2019-03-10 00:00:00

abstract：:The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...

journal_title：International journal of biological sciences

authors： Suzaki Y,Ozawa Y,Kobori H

更新日期：2006-11-01 00:00:00

abstract：:Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...

journal_title：International journal of biological sciences

authors： Hussain G,Wang J,Rasul A,Anwar H,Qasim M,Zafar S,Aziz N,Razzaq A,Hussain R,de Aguilar JG,Sun T

更新日期：2020-01-01 00:00:00

abstract：:Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is known to modulate cell proliferation, differentiation, and migration, all of which are features of ...

journal_title：International journal of biological sciences

authors： Zhang Z,Zhang J,Miao L,Liu K,Yang S,Pan C,Jiao B

更新日期：2012-01-01 00:00:00

abstract：:After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...

journal_title：International journal of biological sciences

authors： Zheng B,Zhou Y,Zhang H,Yang G,Hong Z,Han D,Wang Q,He Z,Liu Y,Wu F,Zhang X,Tong S,Xu H,Xiao J

更新日期：2017-11-27 00:00:00

abstract：:Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene approach is largely limited by its reliance on the priori knowledge about the physiological, biochemical or functional ...

journal_title：International journal of biological sciences

authors： Zhu M,Zhao S

更新日期：2007-10-25 00:00:00

abstract：:Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...

journal_title：International journal of biological sciences

authors： Yao H,Teng Y,Sun Q,Xu J,Chen YT,Hou N,Cheng X,Yang X,Chen ZN

更新日期：2013-12-13 00:00:00

abstract：:Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

journal_title：International journal of biological sciences

authors： Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

更新日期：2018-06-03 00:00:00

abstract：:The loss of wild type p53 tumor suppressive function and oncogenic gain-of-function of p53 mutants have been showing important implications in tumorigenesis. The p53(N236S) (p53(N239S) in human, p53S) mutation has been shown to lose wild type p53 function by yeast assay. However, its gain of function is still not clea...

journal_title：International journal of biological sciences

authors： Jia S,Zhao L,Tang W,Luo Y

更新日期：2012-01-01 00:00:00

abstract：:Statins, known as HMG-CoA reductase (HMGCR) inhibitors, have primarily been utilized for metabolic and angiographic medical applications because of their cholesterol-lowering effects. Similar to other drugs, statins may also induce a series of potential side effects. Statins inhibit the HMGCR (rate-limiting enzyme) ac...

journal_title：International journal of biological sciences

authors： Zhang Q,Dong J,Yu Z

更新日期：2020-08-13 00:00:00

abstract：:Genetic variant T329S in flavin-containing monooxygenase 3 (FMO3) impairs trimethylamine (TMA) metabolism in birds. The TMA metabolism that under complex genetic and dietary regulation, closely linked to cardiovascular disease risk. We determined whether the genetic defects in TMA metabolism may change other metabolic...

journal_title：International journal of biological sciences

authors： Wang J,Long C,Zhang H,Zhang Y,Wang H,Yue H,Wang X,Wu S,Qi G

更新日期：2016-10-25 00:00:00

abstract：:Breast milk is a complex liquid rich in immunological components that affect the development of the infant's immune system. Exosomes are membranous vesicles of endocytic origin that are found in various body fluids and that can mediate intercellular communication. MicroRNAs (miRNAs), a well-defined group of non-coding...

journal_title：International journal of biological sciences

authors： Zhou Q,Li M,Wang X,Li Q,Wang T,Zhu Q,Zhou X,Wang X,Gao X,Li X

更新日期：2012-01-01 00:00:00

abstract：:When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...

journal_title：International journal of biological sciences

authors： Senju H,Kumagai A,Nakamura Y,Yamaguchi H,Nakatomi K,Fukami S,Shiraishi K,Harada Y,Nakamura M,Okamura H,Tanaka Y,Mukae H

更新日期：2018-03-09 00:00:00

abstract：:Pathological cardiac hypertrophy is the response of heart to various biomechanical and physiopathological stimuli, such as aging, myocardial ischemia and hypertension. However, a long-term exposure to the stress makes heart progress to heart failure. Autophagy is a dynamic self-degradative process necessary for the ma...

journal_title：International journal of biological sciences

authors： Li Z,Wang J,Yang X

更新日期：2015-04-27 00:00:00

abstract：:D-Xylitol is found in low content as a natural constituent of many fruits and vegetables. It is a five-carbon sugar polyol and has been used as a food additive and sweetening agent to replace sucrose, especially for non-insulin dependent diabetics. It has multiple beneficial health effects, such as the prevention of d...

journal_title：International journal of biological sciences

authors： Chen X,Jiang ZH,Chen S,Qin W

更新日期：2010-12-15 00:00:00

abstract：:Cardiac metabolic remodeling is recognized as an important hallmark of heart failure (HF), while strategies that target energy metabolism have therapeutic potential in treating HF. Shen-Fu formula (S-F) is a standardized herbal preparation frequently used in clinical practice and is a promising combinatorial therapy f...

journal_title：International journal of biological sciences

authors： Huang Y,Zhang K,Jiang M,Ni J,Chen J,Li L,Deng J,Zhu Y,Mao J,Gao X,Fan G

更新日期：2020-10-16 00:00:00

abstract：:Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half...

journal_title：International journal of biological sciences

authors： Zhao M,Mishra L,Deng CX

更新日期：2018-01-12 00:00:00

abstract：:Pathogens have developed strategies to modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their survival. DCs responses to helminths and their derivatives vary among different studies. Here we show that excretory/secretory products of the cestode Taenia crassi...

journal_title：International journal of biological sciences

authors： Terrazas CA,Sánchez-Muñoz F,Mejía-Domínguez AM,Amezcua-Guerra LM,Terrazas LI,Bojalil R,Gómez-García L

更新日期：2011-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition in plants and animals. At present there is relatively little information regarding the role of miRNAs in the response to drought stress in maize. In this study, ...

journal_title：International journal of biological sciences

authors： Sheng L,Chai W,Gong X,Zhou L,Cai R,Li X,Zhao Y,Jiang H,Cheng B

更新日期：2015-05-22 00:00:00

abstract：:Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in...

journal_title：International journal of biological sciences

authors： Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PC

更新日期：2020-01-01 00:00:00