Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles.


:Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (circRNAs) that may have a broad impact on the early diagnosis and treatment of lung cancer. The circRNAs, exhibiting spatiotemporal-specific expression, are stable and conserved and present diverse biological functions in the normal and diseased states, including cancer. In this review, we summarize the recent advances in elucidating the functional role of circRNAs in lung cancer pathogenesis and discuss their potential mechanisms.


Int J Biol Sci


Zhang C,Ma L,Niu Y,Wang Z,Xu X,Li Y,Yu Y




Has Abstract


2020-01-16 00:00:00












  • Genetic Variant in Flavin-Containing Monooxygenase 3 Alters Lipid Metabolism in Laying Hens in a Diet-Specific Manner.

    abstract::Genetic variant T329S in flavin-containing monooxygenase 3 (FMO3) impairs trimethylamine (TMA) metabolism in birds. The TMA metabolism that under complex genetic and dietary regulation, closely linked to cardiovascular disease risk. We determined whether the genetic defects in TMA metabolism may change other metabolic...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang J,Long C,Zhang H,Zhang Y,Wang H,Yue H,Wang X,Wu S,Qi G

    更新日期:2016-10-25 00:00:00

  • The small molecule PSSM0332 disassociates the CRL4ADCAF8 E3 ligase complex to decrease the ubiquitination of NcoR1 and inhibit the inflammatory response in a mouse sepsis-induced myocardial dysfunction model.

    abstract::Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during the pathogenesis of S...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Peng Q,Xu H,Xiao M,Wang L

    更新日期:2020-09-19 00:00:00

  • Melatonin Stimulates STAR Expression and Progesterone Production via Activation of the PI3K/AKT Pathway in Bovine Theca Cells.

    abstract::Melatonin is present in mammalian follicular fluid and plays an important role in regulating steroidogenesis in follicular cells. In this study, we report the effect of melatonin on steroidogenesis in the theca interna (TI) in small bovine follicles and theca cells (TCs) cultured in vitro. Treatment with melatonin sig...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang X,Meng K,He Y,Wang H,Zhang Y,Quan F

    更新日期:2019-01-01 00:00:00

  • Loop nucleotide polymorphism in a putative miRNA precursor associated with seed length in rice (Oryza sativa L.).

    abstract::The terminal loop region of primary miRNA transcripts is an important determinant controlling miRNA function in human, animals and plants. However, the effects of polymorphisms in loop region of miRNA precusors on phenotypic variation have not been reported, especially on agronomic traits in rice. From rice japonica v...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang C,Ye J,Tang W,Liu Z,Zhu C,Wang M,Wan J

    更新日期:2013-06-16 00:00:00

  • Role of TERRA in the regulation of telomere length.

    abstract::Telomere dysfunction is closely associated with human diseases such as cancer and ageing. Inappropriate changes in telomere length and/or structure result in telomere dysfunction. Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed in...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Wang C,Zhao L,Lu S

    更新日期:2015-02-05 00:00:00

  • Pathological Characterization Of IFNAR(-/-) Mice Infected With Bluetongue Virus Serotype 4.

    abstract::Bluetongue virus (BTV) replicates in lymphoid tissues where infected mononuclear leukocytes secrete proinflammatory and vasoactive mediators that can contribute to bluetongue (BT) pathogenesis. Using the well-characterized IFNAR(-/-) mice animal model, we have now studied the histopathology and dynamics of leukocyte p...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Marín-López A,Bermúdez R,Calvo-Pinilla E,Moreno S,Brun A,Ortego J

    更新日期:2016-11-24 00:00:00

  • Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis.

    abstract::Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

    更新日期:2018-07-27 00:00:00

  • Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication.

    abstract::Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide. Glycosphingolipids (GSLs) are involved in virus infection by regulating various steps of viral-host interaction. However, the distinct role of GSLs during DENV infection remains unclear. In this study, we used mouse melano...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang K,Wang J,Sun T,Bian G,Pan W,Feng T,Wang P,Li Y,Dai J

    更新日期:2016-05-25 00:00:00

  • A novel brain neurovascular unit model with neurons, astrocytes and microvascular endothelial cells of rat.

    abstract::A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and screening the candidates of therapeutic drug. We have first performed the cell identification and morpholo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Xue Q,Liu Y,Qi H,Ma Q,Xu L,Chen W,Chen G,Xu X

    更新日期:2013-01-01 00:00:00

  • Mammalian sirtuins and energy metabolism.

    abstract::Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals t...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Li X,Kazgan N

    更新日期:2011-01-01 00:00:00

  • Combined Features Based on Preoperative Controlling Nutritional Status Score and Circulating Tumour Cell Status Predict Prognosis for Colorectal Cancer Patients Treated with Curative Resection.

    abstract::Background: The preoperative controlling nutritional status (CONUT) score and circulating tumour cell (CTC) status are associated with poor prognosis of colorectal cancer (CRC). The aim of the present study is to determine whether the combination of CONUT and CTC (CONUT-CTC) could better predict the prognosis of CRC p...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Yang C,Wei C,Wang S,Han S,Shi D,Zhang C,Lin X,Dou R,Xiong B

    更新日期:2019-05-12 00:00:00

  • A comprehensive review of web-based resources of non-coding RNAs for plant science research.

    abstract::Non-coding RNAs (ncRNAs) are transcribed from genome but not translated into proteins. Many ncRNAs are key regulators of plants growth and development, metabolism and stress tolerance. In order to make the web-based ncRNA resources for plant science research be more easily accessible and understandable, we made a comp...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Liao P,Li S,Cui X,Zheng Y

    更新日期:2018-05-22 00:00:00

  • Mesenchymal Stem Cells Promote Tumor Progression via Inducing Stroma Remodeling on Rabbit VX2 Bladder Tumor Model.

    abstract::Background and aim: Mesenchymal stem cells (MSCs) are capable of impacting tumor progression but its role in tumor stroma remodeling still remains unclear. This present study was aimed to evaluate the potential function of MSCs on tumor stroma remodeling using rabbits VX2 bladder tumor model. Methods: The VX2 bladder ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Chen J,Ma L,Zhang N,Zhu Y,Zhang K,Xu Z,Wang Q

    更新日期:2018-06-03 00:00:00

  • Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.

    abstract::Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Hussain G,Wang J,Rasul A,Anwar H,Qasim M,Zafar S,Aziz N,Razzaq A,Hussain R,de Aguilar JG,Sun T

    更新日期:2020-01-01 00:00:00

  • Proteome changes in Thai indigenous chicken muscle during growth period.

    abstract::Proteomic profiling of the pectoralis muscle of Thai indigenous chickens during growth period was analyzed using two-dimensional gel electrophoresis (2-DE) and matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF/MS). A total of 259, 161, 120 and 107 protein spots were found to be ex...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Teltathum T,Mekchay S

    更新日期:2009-10-28 00:00:00

  • Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression.

    abstract::Tumor-associated macrophages (TAMs) are closely correlated with tumor occurrence, invasion, and metastasis. However, factors affecting the biological functions of TAMs in colorectal cancer (CRC) are incompletely understood. Here, we found that Wnt5a was mainly expressed on TAMs of tumor stroma but not on CRC cells. Su...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Liu Q,Song J,Pan Y,Shi D,Yang C,Wang S,Xiong B

    更新日期:2020-02-04 00:00:00

  • Simulation of interstitial fluid flow in ligaments: comparison among Stokes, Brinkman and Darcy models.

    abstract::In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Yao W,Shen Z,Ding G

    更新日期:2013-11-05 00:00:00

  • Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy.

    abstract::The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

    更新日期:2013-05-15 00:00:00

  • Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells.

    abstract::Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this study, recombinant lentiviral vectors coding for ZIKV structural proteins and truncations (prM-Env, M-En...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Liu J,Li Q,Li X,Qiu Z,Li A,Liang W,Chen H,Cai X,Chen X,Duan X,Li J,Wu W,Xu M,Mao Y,Chen H,Li J,Gu W,Li H

    更新日期:2018-06-08 00:00:00

  • The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.

    abstract::The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors. In 1996, we and others identified a superfamily of "regulator of G-protein signaling" (RGS) proteins that acc...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Siderovski DP,Willard FS

    更新日期:2005-01-01 00:00:00

  • G721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway.

    abstract::Osteosarcoma (OS) is considered the most common type of primary malignant bone tumor, which has an urgent need for more effective treatment. Recently, chitinase 3 like 1 (Chi3L1) expression has been found in a variety of cancer cells. However it is not known whether Chi3L1 regulates the STAT3 pathway in OS cells. Here...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Park KR,Yun HM,Hong JT

    更新日期:2020-01-01 00:00:00

  • Retinoic Acid Induced-Autophagic Flux Inhibits ER-Stress Dependent Apoptosis and Prevents Disruption of Blood-Spinal Cord Barrier after Spinal Cord Injury.

    abstract::Spinal cord injury (SCI) induces the disruption of the blood-spinal cord barrier (BSCB) which leads to infiltration of blood cells, an inflammatory response, and neuronal cell death, resulting spinal cord secondary damage. Retinoic acid (RA) has a neuroprotective effect in both ischemic brain injury and SCI, however t...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Zhou Y,Zhang H,Zheng B,Ye L,Zhu S,Johnson NR,Wang Z,Wei X,Chen D,Cao G,Fu X,Li X,Xu HZ,Xiao J

    更新日期:2016-01-01 00:00:00

  • Local rheology of human neutrophils investigated using atomic force microscopy.

    abstract::During the immune response, neutrophils display localized mechanical events by interacting with their environment through the micro-vascular transit, trans-endothelial, and trans-epithelial migration. Nano-mechanical studies of human neutrophils on localized nano-domains could provide the essential information for und...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Lee YJ,Patel D,Park S

    更新日期:2011-01-20 00:00:00

  • Different Modulatory Mechanisms of Renal FXYD12 for Na(+)-K(+)-ATPase between Two Closely Related Medakas upon Salinity Challenge.

    abstract::Upon salinity challenge, the Na(+)-K(+)-ATPase (NKA) of fish kidney plays a crucial role in maintaining ion and water balance. Moreover, the FXYD protein family was found to be a regulator of NKA. Our preliminary results revealed that fxyd12 was highly expressed in the kidneys of the two closely related euryhaline med...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Yang WK,Kang CK,Hsu AD,Lin CH,Lee TH

    更新日期:2016-04-28 00:00:00

  • Epigenetic alterations of a novel antioxidant gene SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer.

    abstract::Esophageal squamous cell carcinoma (ESCC) occurs with the highest frequency in China, especially in the high-risk Northern Chinese. Recent studies have reported that SLC22A3 is significantly downregulated in non-tumor (NT) esophageal tissues from familial ESCC patients compared with those from sporadic ESCC. However, ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Xiong JX,Wang YS,Sheng J,Xiang D,Huang TX,Tan BB,Zeng CM,Li HH,Yang J,Meltzer SJ,Mori Y,Qin YR,Guan XY,Fu L

    更新日期:2018-09-07 00:00:00

  • Non-classical p38 map kinase functions: cell cycle checkpoints and survival.

    abstract::The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent years and is now relatively established. Here we discuss the role...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Thornton TM,Rincon M

    更新日期:2009-01-01 00:00:00

  • A new trick of an old molecule: androgen receptor splice variants taking the stage?!

    abstract::Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. Th...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Guo Z,Qiu Y

    更新日期:2011-01-01 00:00:00

  • Genome-wide association analysis of meat quality traits in a porcine Large White × Minzhu intercross population.

    abstract::Pork quality is an economically important trait and one of the main selection criteria for breeding in the swine industry. In this genome-wide association study (GWAS), 455 pigs from a porcine Large White × Minzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip, and phenotyped for intram...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Luo W,Cheng D,Chen S,Wang L,Li Y,Ma X,Song X,Liu X,Li W,Liang J,Yan H,Zhao K,Wang C,Wang L,Zhang L

    更新日期:2012-01-01 00:00:00

  • Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.

    abstract::Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Yang N,Shen HM

    更新日期:2020-03-15 00:00:00

  • Evaluation of Breast Cancer Stem Cells and Intratumor Stemness Heterogeneity in Triple-negative Breast Cancer as Prognostic Factors.

    abstract::Triple-negative breast cancer (TNBC) is a tumor subtype with aggressive behavior and poor clinical outcome for lacking effective therapies. Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains unclear whether their presence contributes to the increased aggressiveness...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Yang F,Cao L,Sun Z,Jin J,Fang H,Zhang W,Guan X

    更新日期:2016-12-07 00:00:00