Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles.


:Lung cancer is one of the most common and deadly malignancies worldwide, in spite of advances in targeted therapy in recent years. An effective strategy for lung cancer prevention remains a major problem. Advances in next-generation sequencing have helped in understanding the RNA and identifying novel circular RNAs (circRNAs) that may have a broad impact on the early diagnosis and treatment of lung cancer. The circRNAs, exhibiting spatiotemporal-specific expression, are stable and conserved and present diverse biological functions in the normal and diseased states, including cancer. In this review, we summarize the recent advances in elucidating the functional role of circRNAs in lung cancer pathogenesis and discuss their potential mechanisms.


Int J Biol Sci


Zhang C,Ma L,Niu Y,Wang Z,Xu X,Li Y,Yu Y




Has Abstract


2020-01-16 00:00:00












  • Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages.

    abstract::Excessive inflammation induced by various risk factors is associated with the development of bronchopulmonary dysplasia (BPD). Caffeine exerts potent anti-inflammatory effects as a clinical preventive medicine for BPD. Recently, NLRP3 inflammasome activation has been demonstrated to be essential for the pathogenesis o...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Zhao W,Ma L,Cai C,Gong X

    更新日期:2019-06-02 00:00:00

  • Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8).

    abstract::As a systemic syndrome characterized by age-associated degenerative skeletal muscle atrophy, sarcopenia leads to a risk of adverse outcomes in the elderly. Age-related iron accumulation is found in the muscles of sarcopenia animal models and patients, but the role of iron in sarcopenia remains poorly understood. It ha...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Huang Y,Wu B,Shen D,Chen J,Yu Z,Chen C

    更新日期:2021-01-01 00:00:00

  • Cestode antigens induce a tolerogenic-like phenotype and inhibit LPS inflammatory responses in human dendritic cells.

    abstract::Pathogens have developed strategies to modify Dendritic Cells (DCs) phenotypes and impair their functions in order to create a safer environment for their survival. DCs responses to helminths and their derivatives vary among different studies. Here we show that excretory/secretory products of the cestode Taenia crassi...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Terrazas CA,Sánchez-Muñoz F,Mejía-Domínguez AM,Amezcua-Guerra LM,Terrazas LI,Bojalil R,Gómez-García L

    更新日期:2011-01-01 00:00:00

  • Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism.

    abstract::Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Kumari A,Pal Pathak D,Asthana S

    更新日期:2020-06-14 00:00:00

  • Effects of diosgenin on myometrial matrix metalloproteinase-2 and -9 activity and expression in ovariectomized rats.

    abstract::Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women. We aimed to investigate the influences of diosgenin administration upon the MMP-2 and -9 activity and expression and reproductive hormones of ovariectomized (OVX) rats, a model of menopausal status. Seven-week old femal...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Chang CC,Kuan TC,Hsieh YY,Ho YJ,Sun YL,Lin CS

    更新日期:2011-01-01 00:00:00

  • Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy.

    abstract::The discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. As CSCs demonstrate resistance to chemoradiation therapy relative to other cancer cells, this allows the enrichment of CSC populations by killing apoptosis-susceptible cancer cells. In this study, three commonl...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang L,Huang X,Zheng X,Wang X,Li S,Zhang L,Yang Z,Xia Z

    更新日期:2013-05-15 00:00:00

  • Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice.

    abstract:PURPOSE:To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice. METHODS:Hearts removed from young adult (5-7 mo) and old (24-28 mo) Ames dwarf and wild-type littermates underwent histological ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Helms SA,Azhar G,Zuo C,Theus SA,Bartke A,Wei JY

    更新日期:2010-09-01 00:00:00

  • NOD2 is involved in the inflammatory response after cerebral ischemia-reperfusion injury and triggers NADPH oxidase 2-derived reactive oxygen species.

    abstract:BACKGROUND:Increasing evidences suggest that innate immunity is involved in cerebral ischemia-reperfusion (I/R) injury, but the liable innate immune receptors have not been completely elucidated. Here, we explored the role of the nucleotide-binding oligomerization domain (NOD)2, a member of the cytosolic NOD-like recep...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Liu H,Wei X,Kong L,Liu X,Cheng L,Yan S,Zhang X,Chen L

    更新日期:2015-03-25 00:00:00

  • Trends in Alzheimer's Disease Research Based upon Machine Learning Analysis of PubMed Abstracts.

    abstract::About 29.8 million people worldwide had been diagnosed with Alzheimer's disease (AD) in 2015, and the number is projected to triple by 2050. In 2018, AD was the fifth leading cause of death in Americans with 65 years of age or older, but the progress of AD drug research is very limited. It is helpful to identify the k...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Guan R,Wen X,Liang Y,Xu D,He B,Feng X

    更新日期:2019-08-06 00:00:00

  • Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication.

    abstract::Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease of humans worldwide. Glycosphingolipids (GSLs) are involved in virus infection by regulating various steps of viral-host interaction. However, the distinct role of GSLs during DENV infection remains unclear. In this study, we used mouse melano...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wang K,Wang J,Sun T,Bian G,Pan W,Feng T,Wang P,Li Y,Dai J

    更新日期:2016-05-25 00:00:00

  • Simulation of interstitial fluid flow in ligaments: comparison among Stokes, Brinkman and Darcy models.

    abstract::In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Yao W,Shen Z,Ding G

    更新日期:2013-11-05 00:00:00

  • Umbelliferone Prevents Lipopolysaccharide-Induced Bone Loss and Suppresses RANKL-Induced Osteoclastogenesis by Attenuating Akt-c-Fos-NFATc1 Signaling.

    abstract::Excessive bone resorption plays a central role in the development of inflammatory bone diseases, including osteoporosis and rheumatoid arthritis. Thus, identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for the prevention and treatment of inflammatory bone los...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Kwak SC,Baek JM,Lee CH,Yoon KH,Lee MS,Kim JY

    更新日期:2019-09-07 00:00:00

  • Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates.

    abstract::Gene silencing techniques are widely used to control gene expression and have potential for RNAi-based therapeutics. In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter. ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Ajiro M,Jia R,Wang RH,Deng CX,Zheng ZM

    更新日期:2015-09-03 00:00:00

  • Proliferation of myoblast skeletal cells on three-dimensional supermacroporous cryogels.

    abstract::Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative approaches in muscle regeneration. The aim of the study was to demonstrate cryogel scaffold potential in the field of ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Singh D,Nayak V,Kumar A

    更新日期:2010-07-03 00:00:00

  • Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis.

    abstract::Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Sha M,Jeong S,Chen XS,Tong Y,Cao J,Sun HY,Xia L,Xu N,Wang X,Han LZ,Xi ZF,Zhang JJ,Kong XN,Xia Q

    更新日期:2018-07-27 00:00:00

  • Enhancement of larval RNAi efficiency by over-expressing Argonaute2 in Bombyx mori.

    abstract::RNA interference has been described as a powerful genetic tool for gene functional analysis and a promising approach for pest management. However, RNAi efficiency varies significantly among insect species due to distinct RNAi machineries. Lepidopteran insects include a large number of pests as well as model insects, s...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Li Z,Zeng B,Ling L,Xu J,You L,Aslam AF,Tan A,Huang Y

    更新日期:2015-01-05 00:00:00

  • Selecting Cells for Bioartificial Liver Devices and the Importance of a 3D Culture Environment: A Functional Comparison between the HepaRG and C3A Cell Lines.

    abstract::Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A. In this study we aimed to compare both cell lines on applicability in BALs...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: van Wenum M,Adam AA,Hakvoort TB,Hendriks EJ,Shevchenko V,van Gulik TM,Chamuleau RA,Hoekstra R

    更新日期:2016-06-24 00:00:00

  • Exosomes from Human Synovial-Derived Mesenchymal Stem Cells Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head in the Rat.

    abstract::Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies in...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Guo SC,Tao SC,Yin WJ,Qi X,Sheng JG,Zhang CQ

    更新日期:2016-10-17 00:00:00

  • A comprehensive review of web-based resources of non-coding RNAs for plant science research.

    abstract::Non-coding RNAs (ncRNAs) are transcribed from genome but not translated into proteins. Many ncRNAs are key regulators of plants growth and development, metabolism and stress tolerance. In order to make the web-based ncRNA resources for plant science research be more easily accessible and understandable, we made a comp...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Liao P,Li S,Cui X,Zheng Y

    更新日期:2018-05-22 00:00:00

  • Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.

    abstract::Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile in nature and can easily get damaged due to acute compression or trauma which may lead to the sensory and motor functions deficits and...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Hussain G,Wang J,Rasul A,Anwar H,Qasim M,Zafar S,Aziz N,Razzaq A,Hussain R,de Aguilar JG,Sun T

    更新日期:2020-01-01 00:00:00

  • FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts.

    abstract::Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Lin X,Zhang Y,Liu L,McKeehan WL,Shen Y,Song S,Wang F

    更新日期:2011-01-01 00:00:00

  • A novel brain neurovascular unit model with neurons, astrocytes and microvascular endothelial cells of rat.

    abstract::A novel triple cell neurovascular unit (NVU) model co-culturing with neurons, brain microvascular endothelial cells (BMECs) and astrocytes was established in this study for investigating the cerebral diseases and screening the candidates of therapeutic drug. We have first performed the cell identification and morpholo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Xue Q,Liu Y,Qi H,Ma Q,Xu L,Chen W,Chen G,Xu X

    更新日期:2013-01-01 00:00:00

  • Structural dynamics and epigenetic modifications of Hoxc loci along the anteroposterior body axis in developing mouse embryos.

    abstract::Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understoo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Min H,Lee JY,Kim MH

    更新日期:2012-01-01 00:00:00

  • Identification of novel focal adhesion kinase substrates: role for FAK in NFκB signaling.

    abstract::Focal adhesion kinase (FAK) is a major signaling molecule which functions downstream of integrins or in conjunction with mitogenic signaling pathways. FAK is overexpressed and/or activated in many types of human tumors, in which it promotes cell adhesion, survival, migration and invasion. In addition to FAK's ability ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Dwyer SF,Gao L,Gelman IH

    更新日期:2015-02-17 00:00:00

  • Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property.

    abstract::Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Wu YJ,Song YN,Geng XR,Ma F,Mo LH,Zhang XW,Liu DB,Liu ZG,Yang PC

    更新日期:2020-01-01 00:00:00

  • Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity.

    abstract::Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Zhang C,George SK,Wu R,Thakker PU,Abolbashari M,Kim TH,Ko IK,Zhang Y,Sun Y,Jackson J,Lee SJ,Yoo JJ,Atala A

    更新日期:2020-01-01 00:00:00

  • Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19.

    abstract::Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (COVID-19). One key el...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章,评审


    authors: Yang N,Shen HM

    更新日期:2020-03-15 00:00:00

  • Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells.

    abstract::Protein phosphatase 2A (PP2A) is a major protein phosphatase with important cell functions. Known and utilized as a potent inhibitor of PP2A, microcystin-LR (MCLR) targets PP2A as a core element that affects numerous cellular mechanisms. But apart from direct inhibition, the exact effect of MCLR on PP2A in cell is lar...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Li T,Huang P,Liang J,Fu W,Guo Z,Xu L

    更新日期:2011-01-01 00:00:00

  • Mast cell-nerve cell interaction at acupoint: modeling mechanotransduction pathway induced by acupuncture.

    abstract::Mast cells are found abundant at sites of acupoints. Nerve cells share perivascular localization with mast cells. Acupuncture (mechanical stimuli) can activate mast cells to release adenosine triphosphate (ATP) which can activate nerve cells and modulates pain-processing pathways in response to acupuncture. In this pa...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Yao W,Yang H,Yin N,Ding G

    更新日期:2014-04-26 00:00:00

  • Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.

    abstract::Objective: Recent studies demonstrate circulating serum spexin levels are reduced in obesity or type 2 diabetes mellitus (T2DM) patients and may play a role in glucose metabolism. The mechanism underlying is not known. In this study, we explore whether spexin has a role in insulin resistance and hepatic glucose metabo...

    journal_title:International journal of biological sciences

    pub_type: 杂志文章


    authors: Gu L,Ding X,Wang Y,Gu M,Zhang J,Yan S,Li N,Song Z,Yin J,Lu L,Peng Y

    更新日期:2019-11-01 00:00:00