Abstract:
:The insulin-like growth factors (IGFs), IGF-I and IGF-II, are essential for regulating cell growth, differentiation and metastasis of a broad range of malignancies. The IGF-I/II actions are mediated through the IGF receptor type 1 (IGF-1R) and the insulin receptor (IR), which are overexpressed in multiple types of tumors. Here, we have firstly identified a human engineered antibody domain (eAd) from a phage-displayed VH library. The eAd suppressed the signal transduction of IGF-1R mediated by exogenous IGF-I or IGF-II in breast cancer cell lines through neutralizing both IGF-I and IGF-II. It also significantly inhibited the growth of breast cancer cells. Therefore, the anti-IGF-I/II eAd offers an alternative approach to target both the IGF-1R signaling pathways through the inhibition of IGF-I/II.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Chen Z,Liu J,Chu D,Shan Y,Ma G,Zhang H,Zhang XD,Wang P,Chen Q,Deng C,Chen W,Dimitrov DS,Zhao Qdoi
10.7150/ijbs.25928subject
Has Abstractpub_date
2018-05-21 00:00:00pages
799-806issue
7issn
1449-2288pii
ijbsv14p0799journal_volume
14pub_type
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