Abstract:
:The vertebrate body plan externally is largely symmetrical across the midline but internal organs develop asymmetrically. The biological basis of asymmetric organ development has been investigated extensively for years, although the proposed mechanisms remain controversial. By comparison, the biological origin of external organs symmetry has not been extensively investigated. Bimanual hand control is one such external organs symmetry allowing independent motor control movements of both hands to a person. This gap in our knowledge is illustrated by the recent reports of heterozygous rad51 mutations causing mysterious symptoms of congenital mirror hand movement disorder (MM) in humans with 50% penetrance by an unknown mechanism. The analysis of mutations that vary symmetry or asymmetry could be exploited to decipher the mechanisms of laterality development. Here I present a hypothesis for explaining 50% penetrance of the rad51 mutation. The MM's origin is explained with the Somatic Strand-specific Imprinting and selective sister chromatid Segregation (SSIS) hypothesis proposed originally as the mechanism of asymmetric cell division to promote visceral organs body plan laterality development in vertebrates. By hypothesis, random sister chromatid segregation in mitosis occurs for a specific chromosome due to rad51/RAD51 constitution causing MM disorder development in 50% of subjects.
journal_name
Int J Biol Scijournal_title
International journal of biological sciencesauthors
Klar AJdoi
10.7150/ijbs.9886subject
Has Abstractpub_date
2014-09-10 00:00:00pages
1018-23issue
9issn
1449-2288pii
ijbsv10p1018journal_volume
10pub_type
杂志文章,评审abstract::Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCC...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.26045
更新日期:2018-07-27 00:00:00
abstract::Aims: The High Mobility Group A1 (HMGA1) proteins, serving as a dynamic regulator of gene transcription and chromatin remodeling, play an influential part in the pathological process of a large number of cardiovascular diseases. However, the precise role of HMGA1 in sepsis induced cardiomyopathy (SIC) remains unintell...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.39947
更新日期:2020-03-26 00:00:00
abstract::It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. But the weakly differential expression signals between two phenotypes are hardly detectable with limited sample sizes. To solve this problem, many researchers tried to combi...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.24548
更新日期:2018-05-22 00:00:00
abstract::With the advancement of nanotechnology, various nanocomposites have been applied in the diagnostics and treatment of cancer. We synthetized FePt nanoparticles which were assembled on the surface of graphene oxide (GO). These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug and enhance radiosensitivit...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.29805
更新日期:2019-03-10 00:00:00
abstract::The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a critical component of the non-homologous end-joining pathway of DNA double-stranded break repair. DNA-PKcs has also been shown recently functioning in mitotic regulation. Here, we report that DNA-PKcs negatively regulates the stability of Cyclin B1 ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.12443
更新日期:2015-07-14 00:00:00
abstract::Reverting activated hepatic stellate cells (HSCs) to less activation or quiescent status is a promising strategy for liver fibrosis. Histone deacetylase inhibitor (HDACI) could suppress HSCs activation. Our previous study demonstrated a critical role of miRNAs in HSCs activation. Here, we explored the involvement of m...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.28642
更新日期:2019-01-06 00:00:00
abstract::Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC ...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.7823
更新日期:2014-01-10 00:00:00
abstract::Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage,...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.297
更新日期:2011-03-25 00:00:00
abstract::Micro-696 (miR-696) has been previously known as an exercise related miRNA, which has a profound role in fatty acid oxidation and mitochondrial biogenesis of skeletal muscle. However, its role in skeletal myoblast proliferation and differentiation is still unclear. In this study, we found that miR-696 expressed highly...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.17508
更新日期:2017-03-11 00:00:00
abstract::The objective of this work was to evaluate the bioavailability of heme iron added to biscuit filling. It comprised two stages: first, the development of the heme iron enriched biscuit filling; second, the evaluation of the bioavailability of the mineral in fattening piglets. Two groups were selected randomly and fed: ...
journal_title:International journal of biological sciences
pub_type: 杂志文章,随机对照试验
doi:10.7150/ijbs.4.58
更新日期:2008-02-18 00:00:00
abstract::Coenzyme Q10 (CoQ10) acts by scavenging reactive oxygen species to protect neuronal cells against oxidative stress in neurodegenerative diseases. The present study was designed to examine whether CoQ10 was capable of protecting astrocytes from reactive oxygen species (ROS) mediated damage. For this purpose, ultraviole...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.10174
更新日期:2015-01-01 00:00:00
abstract::Different stimuli often activate the same intracellular signaling molecules but trigger distinct cell responses. We explored whether or not MAPK signaling induced by macrophage colony-stimulating factor (M-CSF), which is responsible for osteoclast proliferation, differs from that induced by receptor activator of NF-κB...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13814
更新日期:2016-01-01 00:00:00
abstract::In this paper, we use Stokes, Brinkman and Darcy equations to approximate the porous continuum media of ligament tissues respectively, simulate the flow field with FLUENT software, and study the shear stress on the cell surface due to the interstitial fluid flow. Since the Brinkman equation approaches Stokes equation ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7242
更新日期:2013-11-05 00:00:00
abstract::Colon cancer is a malignant type of cancer with high prevalence and is one of the primary causes of cancer-related deaths. Oxaliplatin plays a significant role in the treatment of cancer, but the application of oxaliplatin is restricted due to its toxic side effects and drug resistance in clinical practice. Therefore,...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.35265
更新日期:2019-06-04 00:00:00
abstract::The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the po...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.3.40
更新日期:2006-11-01 00:00:00
abstract::BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues....
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.28142
更新日期:2018-10-03 00:00:00
abstract::When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of pro-IL-18 into mature IL-18. Because natural killer (NK) cells express IL-18 receptors, IL-18 may play roles in immune functions of NK cells. In the present study, we e...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.22809
更新日期:2018-03-09 00:00:00
abstract::Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8134
更新日期:2014-03-10 00:00:00
abstract::Despite significant progressions in treatment modalities over the last decade, either cancer incidence or mortality is continuously on the rise throughout the world. Current anticancer agents display limited efficacy, accompanied by severe side effects. In order to improve therapeutic outcomes in patients with cancer,...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.33710
更新日期:2019-05-07 00:00:00
abstract::Dihydropyrimidinase-related protein 4 (Dpysl4) is a known regulator of hippocampal neuron development. Here, we report that Dpysl4 is involved in growth regulation, polarization and differentiation of dental epithelial cells during tooth germ morphogenesis. A reduction in Dpysl4 gene expression in the tooth germ produ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.5510
更新日期:2013-04-26 00:00:00
abstract::After spinal cord injury (SCI), the destruction of blood-spinal cord barrier (BSCB) is shown to accelerate gathering of noxious blood-derived components in the nervous system, leading to secondary neurodegenerative damages. SCI activates endoplasmic reticulum stress (ER stress), which is considered to evoke secondary ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.21107
更新日期:2017-11-27 00:00:00
abstract::Mitochondrial dysfunction is an important contributor to the development of osteoarthritis (OA). Sirtuin 3 (SIRT3) regulates diverse mitochondrial proteins to maintain mitochondrial homeostasis, and dihydromyricetin (DHM) is reported as a potential SIRT3 activator. This study aims to explore the relevance of SIRT3 and...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.27746
更新日期:2018-10-20 00:00:00
abstract::Perturbation in lipid homeostasis is one of the major bottlenecks in metabolic diseases, especially Non-alcoholic Fatty Liver Disease (NAFLD), which has emerged as a leading global cause of chronic liver disease. The bile acids (BAs) and their derivatives exert a variety of metabolic effects through complex and intert...
journal_title:International journal of biological sciences
pub_type: 杂志文章,评审
doi:10.7150/ijbs.44774
更新日期:2020-06-14 00:00:00
abstract::Gene silencing techniques are widely used to control gene expression and have potential for RNAi-based therapeutics. In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter. ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.13011
更新日期:2015-09-03 00:00:00
abstract::In order to find a blood host and to select appropriate oviposition sites female Anopheles gambiae mosquitoes rely on olfactory cues which are sensed by olfactory sensory neurons (OSNs) located within morphologically different sensilla hairs. While the sharp type trichoid sensilla are most abundant and intensely studi...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.8754
更新日期:2014-03-22 00:00:00
abstract::Autism is a neurodevelopmental disorder with unknown etiology. In some cases, typically developing children regress into clinical symptoms of autism, a condition known as regressive autism. Protein kinases are essential for G-protein-coupled receptor-mediated signal transduction, and are involved in neuronal functions...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.4742
更新日期:2012-01-01 00:00:00
abstract::Purpose: Drug-induced nephrotoxicity can occur in patients with pre-existing renal dysfunction or renal ischemia, potentially leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Prompt treatment of CKD and the related side effects is critical in preventing progression to ESRD. The goal of this ...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.37550
更新日期:2020-01-01 00:00:00
abstract::Capsaicin is the major pungent ingredient in red peppers which is world widely consumed. Except its potent pain relieving efficacy as reported, capsaicin also exerted its antitumor activity in several tumor models. Here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells vi...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7730
更新日期:2014-02-21 00:00:00
abstract::Basigin is a highly glycosylated transmembrane protein that is expressed in a broad range of tissues and is involved in a number of physiological and pathological processes. However, the in vivo role of basigin remains unknown. To better understand the physiological and pathological functions of basigin in vivo, we ge...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.6818
更新日期:2013-12-13 00:00:00
abstract::Protein phosphatase 2A (PP2A) is a major protein phosphatase with important cell functions. Known and utilized as a potent inhibitor of PP2A, microcystin-LR (MCLR) targets PP2A as a core element that affects numerous cellular mechanisms. But apart from direct inhibition, the exact effect of MCLR on PP2A in cell is lar...
journal_title:International journal of biological sciences
pub_type: 杂志文章
doi:10.7150/ijbs.7.740
更新日期:2011-01-01 00:00:00