Abstract：
BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time t, and N1, N2, τ1 and τ2 are parameters. This bi-exponential fit for DSB decay suggests that some breaks are repaired rapidly and other, more complex breaks, take longer to repair. METHODS:The bi-exponential repair kinetics model is implemented into a recent simulation code called RITCARD (Radiation Induced Tracks, Chromosome Aberrations, Repair, and Damage). RITCARD simulates the geometric configuration of human chromosomes, radiation-induced breaks, their repair, and the creation of various categories of CAs. The bi-exponential repair relies on a computational algorithm that is shown to be mathematically exact. To categorize breaks as complex or simple, a threshold for the local (voxel) dose was used. RESULTS:The main findings are: i) the curves for the kinetics of restitution of DSBs are mostly independent of dose; ii) the fraction of unrepaired breaks increases with the linear energy transfer (LET) of the incident radiation; iii) the simulated dose-response curves for simple reciprocal chromosome exchanges that are linear-quadratic; iv) the alpha coefficient of the dose-response curve peaks at about 100 keV/µm.
journal_name
Genes (Basel)journal_title
Genesauthors
Plante I,Slaba T,Shavers Z,Hada Mdoi
10.3390/genes10110936subject
Has Abstractpub_date
2019-11-16 00:00:00issue
11issn
2073-4425pii
genes10110936journal_volume
10pub_type
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