A Third MLPH Variant Causing Coat Color Dilution in Dogs.

abstract：:Adiponectin plays an important role in energy homeostasis and metabolism in mammalian adipose tissue. In this study, the relationship between adiponectin gene (ADIPOQ) haplotypes and variation in growth and carcass traits in New Zealand (NZ) Romney lambs was investigated using General Linear Models (GLMs). Eight haplo...

journal_title：Genes

authors： An Q,Zhou H,Hu J,Luo Y,Hickford JGH

更新日期：2017-06-12 00:00:00

abstract：:Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...

journal_title：Genes

authors： Doksani Y

更新日期：2019-04-24 00:00:00

abstract：:DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G1 phase where it is involved in initiation of DNA replication through interactions with DNA topoisomeras...

journal_title：Genes

authors： Hazeslip L,Zafar MK,Chauhan MZ,Byrd AK

更新日期：2020-05-21 00:00:00

abstract：:Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) gene are the commonest cause of X-linked and recessive retinitis pigmentosa (RP), accounting for 10%-20% of all cases of RP. The phenotype is one of the most severe amongst all causes of RP, characteristic for its early onset and rapid progression to...

journal_title：Genes

authors： Cehajic Kapetanovic J,McClements ME,Martinez-Fernandez de la Camara C,MacLaren RE

更新日期：2019-09-04 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is an extremely aggressive disease with a high metastatic potential. Most patients are diagnosed with metastatic disease, at which the five-year survival rate is only 3%. A better understanding of the mechanisms that drive metastasis is imperative for the development of better therapeu...

journal_title：Genes

authors： Ayres Pereira M,Chio IIC

更新日期：2019-12-19 00:00:00

abstract：:More than fifteen genetic diseases, including Huntington's disease, myotonic dystrophy 1, fragile X syndrome and Friedreich ataxia, are caused by the aberrant expansion of a trinucleotide repeat. The mutation is unstable and further expands in specific cells or tissues with time, which can accelerate disease progressi...

journal_title：Genes

authors： Goula AV,Merienne K

更新日期：2013-07-25 00:00:00

abstract：:Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...

journal_title：Genes

authors： Heep M,Mach P,Reautschnig P,Wettengel J,Stafforst T

更新日期：2017-01-14 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...

journal_title：Genes

authors： Gemayel R,Cho J,Boeynaems S,Verstrepen KJ

更新日期：2012-07-26 00:00:00

abstract：:Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. T...

journal_title：Genes

authors： Qanmber G,Ali F,Lu L,Mo H,Ma S,Wang Z,Yang Z

更新日期：2019-05-09 00:00:00

abstract：:It is well established that embryonic chromosomal abnormalities (both in the number of chromosomes and the structure) account for 50% of early pregnancy losses. However, little is known regarding the potential differences in the incidence and distribution of chromosomal abnormalities between patients with sporadic abo...

journal_title：Genes

authors： Sheng YR,Hou SY,Hu WT,Wei CY,Liu YK,Liu YY,Jiang L,Xiang JJ,Sun XX,Lei CX,Wang HL,Zhu XY

更新日期：2021-01-22 00:00:00

abstract：:The nitrogen use efficiency (NUE) of crop plants is limited and enhancing it in rice, a major cereal crop, would be beneficial for farmers and the environment alike. Here we report the genome-wide transcriptome analysis of two rice genotypes, IR 64 (IR64) and Nagina 22 (N22) under optimal (+N) and chronic starvation (...

journal_title：Genes

authors： Sinha SK,Sevanthi V AM,Chaudhary S,Tyagi P,Venkadesan S,Rani M,Mandal PK

更新日期：2018-04-11 00:00:00

abstract：:Plants grown under highly variable natural light regimes differ strongly from plants grown under constant light (CL) regimes. Plant phenotype and adaptation responses are important for plant biomass and fitness. However, the underlying regulatory mechanisms are still poorly understood, particularly from a transcriptio...

journal_title：Genes

authors： Ding J,Zhao J,Pan T,Xi L,Zhang J,Zou Z

更新日期：2019-08-29 00:00:00

abstract：:As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a prom...

journal_title：Genes

authors： Zhang J,Kaiser MG,Gallardo RA,Kelly TR,Dekkers JCM,Zhou H,Lamont SJ

更新日期：2020-08-26 00:00:00

abstract：:Pseudomonas savastanoi pv. savastanoi is the causal agent of Olive knot disease, relying on the Type Three Secretion System (TTSS) for its pathogenicity. In this regard, nothing was known about the two other pathovars belonging to this species, pv. nerii and pv. fraxini, characterized by a different host range. Here w...

journal_title：Genes

authors： Tegli S,Gori A,Cerboneschi M,Cipriani MG,Sisto A

更新日期：2011-11-25 00:00:00

abstract：:Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...

journal_title：Genes

authors： Xia X

更新日期：2020-08-25 00:00:00

abstract：:The complete mutational spectrum of dystrophinopathies and limb-girdle muscular dystrophy (LGMD) remains unknown in Mexican population. Seventy-two unrelated Mexican male patients (73% of pediatric age) with clinical suspicion of muscular dystrophy and no evidence of DMD gene deletion on multiplex polymerase chain rea...

journal_title：Genes

authors： Alcántara-Ortigoza MA,Reyna-Fabián ME,González-Del Angel A,Estandia-Ortega B,Bermúdez-López C,Cruz-Miranda GM,Ruíz-García M

更新日期：2019-10-29 00:00:00

abstract：:Circadian clocks in eukaryotes involve both transcriptional-translational feedback loops, post-translational regulation, and metabolic, non-transcriptional oscillations. We recently identified the involvement of circadian oscillations in the intracellular concentrations of magnesium ions (Mg2+i) that were conserved in...

journal_title：Genes

authors： Feord HK,Dear FEG,Obbard DJ,van Ooijen G

更新日期：2019-02-19 00:00:00

abstract：:Smoking is one of the leading preventable causes of morbidity and mortality worldwide, prompting interest in its association with DNA methylation-based measures of biological aging. Considerable progress has been made in developing DNA methylation-based measures that correspond to self-reported smoking status. In addi...

journal_title：Genes

authors： Lei MK,Gibbons FX,Simons RL,Philibert RA,Beach SRH

更新日期：2020-03-14 00:00:00

abstract：:The grizzly bear (Ursus arctos ssp. horribilis) represents the largest population of brown bears in North America. Its genome was sequenced using a microfluidic partitioning library construction technique, and these data were supplemented with sequencing from a nanopore-based long read platform. The final assembly was...

journal_title：Genes

authors： Taylor GA,Kirk H,Coombe L,Jackman SD,Chu J,Tse K,Cheng D,Chuah E,Pandoh P,Carlsen R,Zhao Y,Mungall AJ,Moore R,Birol I,Franke M,Marra MA,Dutton C,Jones SJM

更新日期：2018-11-30 00:00:00

abstract：:In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction....

journal_title：Genes

authors： Liu G,Xuan N,Rajashekar B,Arnaud P,Offmann B,Picimbon JF

更新日期：2020-04-10 00:00:00

abstract：:The homeodomain-leucine zipper (HD-Zip) transcription factor family is a key transcription factor family and unique to the plant kingdom. It consists of a homeodomain and a leucine zipper that serve in combination as a dimerization motif. The family can be classified into four subfamilies, and these subfamilies partic...

journal_title：Genes

authors： Song A,Li P,Xin J,Chen S,Zhao K,Wu D,Fan Q,Gao T,Chen F,Guan Z

更新日期：2016-05-17 00:00:00

abstract：:Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks ...

journal_title：Genes

authors： Rubin DA,Wilson KS,Orsso CE,Gertz ER,Haqq AM,Castner DM,Dumont-Driscoll M

更新日期：2020-08-24 00:00:00

abstract：:Hypersialylation caused by the overexpression of sialyltransferases (STs) is a common feature in cancer that is associated with several characteristics of tumorigenesis. Thus, identifying cancer-associated STs is critical for cancer therapy. However, ST screening has been frequently conducted in cell line models. In t...

journal_title：Genes

authors： Kan JY,Moi SH,Hung WC,Hou MF,Chen FM,Shih SL,Shiau JP,Li CL,Chiang CP

更新日期：2020-11-28 00:00:00

abstract：:PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...

journal_title：Genes

authors： Yvert T,Miyamoto-Mikami E,Tobina T,Shiose K,Kakigi R,Tsuzuki T,Takaragawa M,Ichinoseki-Sekine N,Pérez M,Kobayashi H,Tanaka H,Naito H,Fuku N

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...

journal_title：Genes

authors： Buiga P,Elson A,Tabernero L,Schwartz JM

更新日期：2019-07-26 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens associated with outbreaks and hemolytic-uremic syndrome. Cattle and meat foods are the main reservoir and infection source, respectively. Pathogenicity islands (PAIs) play an important role in STEC pathogenicity, and non-locus of the enterocyte effa...

journal_title：Genes

authors： Soledad-Cadona J,Bustamante AV,González J,Mariel-Sanso A

更新日期：2018-02-10 00:00:00

abstract：:Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...

journal_title：Genes

authors： Liu H,Li Q,Xing Y

更新日期：2018-10-10 00:00:00

abstract：:Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

journal_title：Genes

authors： Gimenez E,Manzano-Agugliaro F

更新日期：2017-10-30 00:00:00