Abstract：
:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chromosome dosage compensation in male somatic tissues, but not in testis. The X chromosome contains disproportionately fewer genes with high expression in testis than the autosomes, even after accounting for the lack of dosage compensation, which suggests that another mechanism suppresses their expression in the male germline. This is consistent with studies of reporter genes and transposed genes, which find that the same gene has higher expression when autosomal than when X-linked. Using a new reporter gene that is expressed in both testis and somatic tissues, we find that the suppression of X-linked gene expression is limited to genes with high expression in testis and that the extent of the suppression is positively correlated with expression level.
journal_name
Genes (Basel)journal_title
Genesauthors
Argyridou E,Parsch Jdoi
10.3390/genes9050242subject
Has Abstractpub_date
2018-05-04 00:00:00issue
5issn
2073-4425pii
genes9050242journal_volume
9pub_type
杂志文章相关文献
Genes文献大全abstract：:Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was perfo...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11101201
更新日期：2020-10-15 00:00:00
abstract：:The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120391
更新日期：2017-12-15 00:00:00
abstract：:Meiosis yields haploid gametes following two successive divisions of a germ cell in the absence of intervening DNA replication. Balanced segregation of homologous chromosomes in Meiosis I is aided by a proteinaceous structure, the synaptonemal complex (SC). The objective of this study was to determine total average au...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes1030505
更新日期：2010-12-15 00:00:00
abstract：:DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA damage during replication. These pathways include translesion synthesis and template switching. These pathways are regulated largely through post-translational modif...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11020138
更新日期：2020-01-29 00:00:00
abstract：:Warmblood fragile foal syndrome (WFFS) is an autosomal recessive disorder caused by a single nucleotide variant in the procollagen-lysine-2-oxoglutarate-5-dioxygenase 1 gene (PLOD1:c.2032G>A, p.Gly678Arg). Homozygosity for the PLOD1 variant causes an Ehler-Danlos-like syndrome, which has to date only been reported in ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121518
更新日期：2020-12-18 00:00:00
abstract：:Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10060425
更新日期：2019-06-03 00:00:00
abstract：:Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10100817
更新日期：2019-10-17 00:00:00
abstract：:Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes3020320
更新日期：2012-05-29 00:00:00
abstract：:Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins' structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking the replication forks near the origins using two different origi...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes4020198
更新日期：2013-04-17 00:00:00
abstract：:Shewanella oneidensis MR-1 can transfer electrons from the intracellular environment to the extracellular space of the cells to reduce the extracellular insoluble electron acceptors (Extracellular Electron Transfer, EET). Benefiting from this EET capability, Shewanella has been widely used in different areas, such as ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9010041
更新日期：2018-01-16 00:00:00
abstract：:A 9-month old male Jack Russell Terrier started showing paraparesis of the hindlimbs after a walk. Hospitalized, the dog went into cardiac arrest, and later died. Necroscopic examination revealed a severe thickness of the diaphragm, esophagus, and base of the tongue, leading to the diagnosis of muscular dystrophy. The...
journal_title：Genes
pub_type：
doi：10.3390/genes11101175
更新日期：2020-10-08 00:00:00
abstract：:The facultative aerobic bacterium Escherichia coli adjusts its cell cycle to environmental conditions. Because of its lifestyle, the bacterium has to balance the use of oxygen with the potential lethal effects of its poisonous derivatives. Oxidative damages perpetrated by molecules such as hydrogen peroxide and supero...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9110565
更新日期：2018-11-21 00:00:00
abstract：:B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9080388
更新日期：2018-07-31 00:00:00
abstract：:Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) with incr...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040358
更新日期：2020-03-27 00:00:00
abstract：:The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl ("long") and NF-YAs ("short"). Little is known about the expression levels of NF-Y subunits in tumors, and nothing in lung cancer. By interrogating RNA-seq TCGA and GEO datasets,...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110937
更新日期：2019-11-17 00:00:00
abstract：:The accurate repair of DNA is critical for genome stability and cancer prevention. DNA double-strand breaks are one of the most toxic lesions; however, they can be repaired using homologous recombination. Homologous recombination is a high-fidelity DNA repair pathway that uses a homologous template for repair. One cen...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9120629
更新日期：2018-12-13 00:00:00
abstract：:Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade of molecular events underlying testis cord de...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10120974
更新日期：2019-11-26 00:00:00
abstract：:Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes2020384
更新日期：2011-05-31 00:00:00
abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10080568
更新日期：2019-07-26 00:00:00
abstract：:DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that needs to be faithfully replicated during mitosis in order to maintain cell phenotype during successive cell divisions. This epigenetic mark is located on the 5'-carbon of the cytosine mainly within cytosine⁻phosphate⁻guanine (CpG)...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10010065
更新日期：2019-01-18 00:00:00
abstract：:Segments of the genome enriched in repetitive sequences still present a challenge and are omitted in genome assemblies. For that reason, the exact composition of DNA sequences underlying the heterochromatic regions and the active centromeres are still unexplored for many organisms. The centromere is a crucial region o...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11060695
更新日期：2020-06-24 00:00:00
abstract：:Inositol trisphosphate receptor (IP3R) mediated Ca+2 signaling is essential in determining the cell fate by regulating numerous cellular processes, including cell division and cell death. Despite extensive studies about the characterization of IP3R in cancer, the underlying molecular mechanism initiating the cell prol...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes12010034
更新日期：2020-12-29 00:00:00
abstract：:The convergence of distinct lineages upon interspecific hybridisation, including when accompanied by increases in ploidy (allopolyploidy), is a driving force in the origin of many plant species. In plant breeding too, both interspecific hybridisation and allopolyploidy are important because they facilitate introgressi...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes1020166
更新日期：2010-07-02 00:00:00
abstract：:Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi [...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes10020161
更新日期：2019-02-20 00:00:00
abstract：:Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10090639
更新日期：2019-08-23 00:00:00
abstract：:Novel coat colour phenotypes often emerge during domestication, and there is strong evidence of genetic selection for the two main genes that control base coat colour in horses-ASIP and MC1R. These genes direct the type of pigment produced, red pheomelanin (MC1R) or black eumelanin (ASIP), as well as the relative conc...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11060606
更新日期：2020-05-30 00:00:00
abstract：:Individual cells in an organism are variable, which strongly impacts cellular processes. Advances in sequencing technologies have enabled single-cell genomic analysis to become widespread, addressing shortcomings of analyses conducted on populations of bulk cells. While the field of single-cell plant genomics is in it...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9010050
更新日期：2018-01-22 00:00:00
abstract：:Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes7050020
更新日期：2016-05-13 00:00:00
abstract：:Cytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11111348
更新日期：2020-11-13 00:00:00
abstract：:During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining (NHEJ) or sequence dependent by homology directed repair (HDR). Whereas NHEJ-based generation of gene knock-out is widely performed, the HDR-based knock-in of speci...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060296
更新日期：2018-06-13 00:00:00
