听力与言语-语言病理学

行为科学

医学伦理学

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  • Paternal Uniparental Disomy of the Entire Chromosome 20 in a Child with Beckwith-Wiedemann Syndrome.

    abstract::Epigenetic alterations at imprinted genes on different chromosomes have been linked to several imprinting disorders (IDs) such as Beckwith-Wiedemann syndrome (BWS) and pseudohypoparathyroidism type 1b (PHP1b). Here, we present a male patient with these two distinct IDs caused by two independent mechanisms-loss of meth...

    journal_title:Genes

    pub_type:

    doi:10.3390/genes12020172

    authors: Choufani S,Ko JM,Lou Y,Shuman C,Fishman L,Weksberg R

    更新日期:2021-01-27 00:00:00

  • Graph Algorithms for Mixture Interpretation.

    abstract::The scale of genetic methods are presently being expanded: forensic genetic assays previously were limited to tens of loci, but now technologies allow for a transition to forensic genomic approaches that assess thousands to millions of loci. However, there are subtle distinctions between genetic assays and their genom...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12020185

    authors: Crysup B,Woerner AE,King JL,Budowle B

    更新日期:2021-01-27 00:00:00

  • Characterization of Copy-Number Variations and Possible Candidate Genes in Recurrent Pregnancy Losses.

    abstract::It is well established that embryonic chromosomal abnormalities (both in the number of chromosomes and the structure) account for 50% of early pregnancy losses. However, little is known regarding the potential differences in the incidence and distribution of chromosomal abnormalities between patients with sporadic abo...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12020141

    authors: Sheng YR,Hou SY,Hu WT,Wei CY,Liu YK,Liu YY,Jiang L,Xiang JJ,Sun XX,Lei CX,Wang HL,Zhu XY

    更新日期:2021-01-22 00:00:00

  • Evaluation of DNA Extraction Methods Developed for Forensic and Ancient DNA Applications Using Bone Samples of Different Age.

    abstract::The efficient extraction of DNA from challenging samples, such as bones, is critical for the success of downstream genotyping analysis in molecular genetic disciplines. Even though the ancient DNA community has developed several protocols targeting small DNA fragments that are typically present in decomposed or old sp...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12020146

    authors: Xavier C,Eduardoff M,Bertoglio B,Amory C,Berger C,Casas-Vargas A,Pallua J,Parson W

    更新日期:2021-01-22 00:00:00

  • Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies.

    abstract::Hepatic lipase (encoded by LIPC) is a glycoprotein in the triacylglycerol lipase family and mainly synthesized in and secreted from the liver. Previous studies demonstrated that hepatic lipase is crucial for reverse cholesterol transport and modulating metabolism and the plasma levels of several lipoproteins. This stu...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12020148

    authors: Liao YH,Er LK,Wu S,Ko YL,Teng MS

    更新日期:2021-01-22 00:00:00

  • Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis.

    abstract::The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12020129

    authors: Baker Frost D,da Silveira W,Hazard ES,Atanelishvili I,Wilson RC,Flume J,Day KL,Oates JC,Bogatkevich GS,Feghali-Bostwick C,Hardiman G,Ramos PS

    更新日期:2021-01-20 00:00:00

  • Inhibition of the Lipid Droplet-Peroxisome Proliferator-Activated Receptor α Axis Suppresses Cancer Stem Cell Properties.

    abstract::Cancer stem cells (CSCs), having both self-renewal and tumorigenic capacity, utilize an energy metabolism system different from that of non-CSCs. Lipid droplets (LDs) are organelles that store neutral lipids, including triacylglycerol. Previous studies demonstrated that LDs are formed and store lipids as an energy sou...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12010099

    authors: Kuramoto K,Yamamoto M,Suzuki S,Togashi K,Sanomachi T,Kitanaka C,Okada M

    更新日期:2021-01-14 00:00:00

  • Circulating miR-206 as a Biomarker for Patients Affected by Severe Limb Girdle Muscle Dystrophies.

    abstract::Limb-girdle muscular dystrophies (LGMD) are clinically and genetically heterogeneous conditions, presenting with a wide clinical spectrum, leading to progressive proximal weakness caused by loss of muscle fibers. MiR-206 is a member of myomiRNAs, a group of miRNAs with important function in skeletal muscle. Our aim is...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12010085

    authors: Pegoraro V,Angelini C

    更新日期:2021-01-12 00:00:00

  • Effect of ACTN3 R577X Genotype on Injury Epidemiology in Elite Endurance Runners.

    abstract::The p.R577X polymorphism (rs1815739) in the ACTN3 gene causes individuals with the ACTN3 XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries. This investigation aimed to determine the influence of the ACTN3 R577...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12010076

    authors: Gutiérrez-Hellín J,Baltazar-Martins G,Aguilar-Navarro M,Ruiz-Moreno C,Oliván J,Del Coso J

    更新日期:2021-01-08 00:00:00

  • The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia.

    abstract::Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR, APOB, and PCSK9 genes potentially associated with FH have been described earlier. Nev...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12010066

    authors: Meshkov A,Ershova A,Kiseleva A,Zotova E,Sotnikova E,Petukhova A,Zharikova A,Malyshev P,Rozhkova T,Blokhina A,Limonova A,Ramensky V,Divashuk M,Khasanova Z,Bukaeva A,Kurilova O,Skirko O,Pokrovskaya M,Mikova V,Snigir E

    更新日期:2021-01-06 00:00:00

  • From the Outside to the Inside: New Insights on the Main Factors That Guide Seed Dormancy and Germination.

    abstract::The transition from a dormant to a germinating seed represents a crucial developmental switch in the life cycle of a plant. Subsequent transition from a germinating seed to an autotrophic organism also requires a robust and multi-layered control. Seed germination and seedling growth are multistep processes, involving ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes12010052

    authors: Longo C,Holness S,De Angelis V,Lepri A,Occhigrossi S,Ruta V,Vittorioso P

    更新日期:2020-12-31 00:00:00

  • Biological Regulatory Network (BRN) Analysis and Molecular Docking Simulations to Probe the Modulation of IP3R Mediated Ca2+ Signaling in Cancer.

    abstract::Inositol trisphosphate receptor (IP3R) mediated Ca+2 signaling is essential in determining the cell fate by regulating numerous cellular processes, including cell division and cell death. Despite extensive studies about the characterization of IP3R in cancer, the underlying molecular mechanism initiating the cell prol...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes12010034

    authors: Ismatullah H,Jabeen I,Saeed MT

    更新日期:2020-12-29 00:00:00

  • You Had Me at "MAGIC"!: Four Barley MAGIC Populations Reveal Novel Resistance QTL for Powdery Mildew.

    abstract::Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations comb...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121512

    authors: Novakazi F,Krusell L,Jensen JD,Orabi J,Jahoor A,Bengtsson T,On Behalf Of The Ppp Barley Consortium

    更新日期:2020-12-18 00:00:00

  • Distribution of the Warmblood Fragile Foal Syndrome Type 1 Mutation (PLOD1 c.2032G>A) in Different Horse Breeds from Europe and the United States.

    abstract::Warmblood fragile foal syndrome (WFFS) is an autosomal recessive disorder caused by a single nucleotide variant in the procollagen-lysine-2-oxoglutarate-5-dioxygenase 1 gene (PLOD1:c.2032G>A, p.Gly678Arg). Homozygosity for the PLOD1 variant causes an Ehler-Danlos-like syndrome, which has to date only been reported in ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121518

    authors: Reiter S,Wallner B,Brem G,Haring E,Hoelzle L,Stefaniuk-Szmukier M,Długosz B,Piórkowska K,Ropka-Molik K,Malvick J,Penedo MCT,Bellone RR

    更新日期:2020-12-18 00:00:00

  • Two Separate Cases: Complex Chromosomal Abnormality Involving Three Chromosomes and Small Supernumerary Marker Chromosome in Patients with Impaired Reproductive Function.

    abstract::For medical genetic counseling, estimating the chance of a child being born with chromosome abnormality is crucially important. Cytogenetic diagnostics of parents with a balanced karyotype are a special case. Such chromosome rearrangements cannot be detected with comprehensive chromosome screening. In the current pape...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121511

    authors: Karamysheva TV,Gayner TA,Muzyka VV,Orishchenko KE,Rubtsov NB

    更新日期:2020-12-17 00:00:00

  • Extracellular Vesicles-Mediated Transfer of miRNA Let-7b from PC3 Cells to Macrophages.

    abstract::Prostate-derived extracellular vesicles (pEVs) may represent a way to selectively transport cargo molecules from the producing cells to the target cells to allow biological events, both in physiological and pathological circumstances. pEVs cargo participates in the modulation of the inflammatory responses in physiolog...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121495

    authors: Costanzi E,Romani R,Scarpelli P,Bellezza I

    更新日期:2020-12-12 00:00:00

  • Genome-Wide Association Study (GWAS) for Resistance to Sclerotinia sclerotiorum in Common Bean.

    abstract::White mold (WM) is a devastating fungal disease affecting common bean (Phaseolus vulgaris L.). In this research, a genome-wide association study (GWAS) for WM resistance was conducted using 294 lines of the Spanish diversity panel. One single-locus method and six multi-locus methods were used in the GWAS. Response to ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121496

    authors: Campa A,García-Fernández C,Ferreira JJ

    更新日期:2020-12-12 00:00:00

  • The Puzzling Fate of a Lupin Chromosome Revealed by Reciprocal Oligo-FISH and BAC-FISH Mapping.

    abstract::Old World lupins constitute an interesting model for evolutionary research due to diversity in genome size and chromosome number, indicating evolutionary genome reorganization. It has been hypothesized that the polyploidization event which occurred in the common ancestor of the Fabaceae family was followed by a lineag...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121489

    authors: Bielski W,Książkiewicz M,Šimoníková D,Hřibová E,Susek K,Naganowska B

    更新日期:2020-12-10 00:00:00

  • 46,XY,r(8)/45,XY,-8 Mosaicism as a Possible Mechanism of the Imprinted Birk-Barel Syndrome: A Case Study.

    abstract::Ring chromosome 8 (r(8)) is one of the least frequent ring chromosomes. Usually, maternal chromosome 8 forms a ring, which can be lost from cells due to mitotic instability. The 8q24 region contains the imprinted KCNK9 gene, which is expressed from the maternal allele. Heterozygous KCNK9 mutations are associated with ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121473

    authors: Kashevarova AA,Nikitina TV,Mikhailik LI,Belyaeva EO,Vasilyev SA,Lopatkina ME,Fedotov DA,Fonova EA,Zarubin AA,Sivtsev AA,Skryabin NA,Nazarenko LP,Lebedev IN

    更新日期:2020-12-09 00:00:00

  • Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining.

    abstract::The TDP1 (tyrosyl-DNA phosphodiesterase 1) enzyme removes the non-specific covalent intermediates between topoisomerase I and DNA, thus playing a crucial role in preventing DNA damage. While mammals possess only one TDP1 gene, in plants two genes (TDP1α and TDP1β) are present constituting a small gene subfamily. These...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121465

    authors: Mutti G,Raveane A,Pagano A,Bertolini F,Semino O,Balestrazzi A,Macovei A

    更新日期:2020-12-07 00:00:00

  • Novel Variant in PLAG1 in a Familial Case with Silver-Russell Syndrome Suspicion.

    abstract::Silver-Russell syndrome (SRS) is a rare growth-related genetic disorder that is mainly associated with prenatal and postnatal growth retardation. Molecular causes are not clear in all cases, the most common ones being loss of methylation on chromosome 11p15 (≈50%) and maternal uniparental disomy for chromosome 7 (upd(...

    journal_title:Genes

    pub_type:

    doi:10.3390/genes11121461

    authors: Vado Y,Pereda A,Llano-Rivas I,Gorria-Redondo N,Díez I,Perez de Nanclares G

    更新日期:2020-12-05 00:00:00

  • Development and Cell Cycle Activity of the Root Apical Meristem in the Fern Ceratopteris richardii.

    abstract::Ferns are a representative clade in plant evolution although underestimated in the genomic era. Ceratopteris richardii is an emergent model for developmental processes in ferns, yet a complete scheme of the different growth stages is necessary. Here, we present a developmental analysis, at the tissue and cellular leve...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121455

    authors: Aragón-Raygoza A,Vasco A,Blilou I,Herrera-Estrella L,Cruz-Ramírez A

    更新日期:2020-12-04 00:00:00

  • Technologies for Pharmacogenomics: A Review.

    abstract::The continuous development of new genotyping technologies requires awareness of their potential advantages and limitations concerning utility for pharmacogenomics (PGx). In this review, we provide an overview of technologies that can be applied in PGx research and clinical practice. Most commonly used are single nucle...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11121456

    authors: van der Lee M,Kriek M,Guchelaar HJ,Swen JJ

    更新日期:2020-12-04 00:00:00

  • Whether Gametophytes are Reduced or Unreduced in Angiosperms Might Be Determined Metabolically.

    abstract::In angiosperms, meiotic failure coupled with the formation of genetically unreduced gametophytes in ovules (apomeiosis) constitute major components of gametophytic apomixis. These aberrant developmental events are generally thought to be caused by mutation. However, efforts to locate the responsible mutations have fai...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121449

    authors: Mateo de Arias M,Gao L,Sherwood DA,Dwivedi KK,Price BJ,Jamison M,Kowallis BM,Carman JG

    更新日期:2020-12-02 00:00:00

  • How Hormones and MADS-Box Transcription Factors Are Involved in Controlling Fruit Set and Parthenocarpy in Tomato.

    abstract::Fruit set is the earliest phase of fruit growth and represents the onset of ovary growth after successful fertilization. In parthenocarpy, fruit formation is less affected by environmental factors because it occurs in the absence of pollination and fertilization, making parthenocarpy a highly desired agronomic trait. ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11121441

    authors: Molesini B,Dusi V,Pennisi F,Pandolfini T

    更新日期:2020-11-30 00:00:00

  • Eco-Evolutionary Feedbacks and the Maintenance of Metacommunity Diversity in a Changing Environment.

    abstract::The presence and strength of resource competition can influence how organisms adaptively respond to environmental change. Selection may thus reflect a balance between two forces, adaptation to an environmental optimum and evolution to avoid strong competition. While this phenomenon has previously been explored in the ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121433

    authors: Fielding AP,Pantel JH

    更新日期:2020-11-28 00:00:00

  • TYK2 Variants in B-Acute Lymphoblastic Leukaemia.

    abstract::B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN-α/β receptor alpha chain (IF...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121434

    authors: Turrubiartes-Martínez E,Bodega-Mayor I,Delgado-Wicke P,Molina-Jiménez F,Casique-Aguirre D,González-Andrade M,Rapado I,Camós M,Díaz-de-Heredia C,Barragán E,Ramírez-Orellana M,Aguado B,Figuera Á,Martínez-López J,Fernández-Ruiz

    更新日期:2020-11-28 00:00:00

  • Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.

    abstract::Hypersialylation caused by the overexpression of sialyltransferases (STs) is a common feature in cancer that is associated with several characteristics of tumorigenesis. Thus, identifying cancer-associated STs is critical for cancer therapy. However, ST screening has been frequently conducted in cell line models. In t...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121436

    authors: Kan JY,Moi SH,Hung WC,Hou MF,Chen FM,Shih SL,Shiau JP,Li CL,Chiang CP

    更新日期:2020-11-28 00:00:00

  • PupStruct: Prediction of Pupylated Lysine Residues Using Structural Properties of Amino Acids.

    abstract::Post-translational modification (PTM) is a critical biological reaction which adds to the diversification of the proteome. With numerous known modifications being studied, pupylation has gained focus in the scientific community due to its significant role in regulating biological processes. The traditional experimenta...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121431

    authors: Singh V,Sharma A,Dehzangi A,Tsunoda T

    更新日期:2020-11-28 00:00:00

  • Slow Adaptive Response of Budding Yeast Cells to Stable Conditions of Continuous Culture Can Occur without Genome Modifications.

    abstract::Continuous cultures assure the invariability of environmental conditions and the metabolic state of cultured microorganisms, whereas batch-cultured cells undergo constant changes in nutrients availability. For that reason, continuous culture is sometimes employed in the whole transcriptome, whole proteome, or whole me...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121419

    authors: Klim J,Zielenkiewicz U,Kurlandzka A,Kaczanowski S,Skoneczny M

    更新日期:2020-11-27 00:00:00

  • Properties and Therapeutic Implications of an Enigmatic D477G RPE65 Variant Associated with Autosomal Dominant Retinitis Pigmentosa.

    abstract::RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11121420

    authors: Kiang AS,Kenna PF,Humphries MM,Ozaki E,Koenekoop RK,Campbell M,Farrar GJ,Humphries P

    更新日期:2020-11-27 00:00:00

  • Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer.

    abstract::Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIMPs) are continually being implicated in tumorigenesis, but these conn...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111384

    authors: Wang J,Vallee I,Dutta A,Wang Y,Mo Z,Liu Z,Cui H,Su AI,Yang XL

    更新日期:2020-11-22 00:00:00

  • Gene Expression Profile in Similar Tissues Using Transcriptome Sequencing Data of Whole-Body Horse Skeletal Muscle.

    abstract::Horses have been studied for exercise function rather than food production, unlike most livestock. Therefore, the role and characteristics of tissue landscapes are critically understudied, except for certain muscles used in exercise-related studies. In the present study, we compared RNA-Seq data from 18 Jeju horse ske...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111359

    authors: Lee HY,Kim JY,Kim KH,Jeong S,Cho Y,Kim N

    更新日期:2020-11-17 00:00:00

  • Reducing the Number of Mismatches between Hairs and Buccal References When Analysing mtDNA Heteroplasmic Variation by Massively Parallel Sequencing.

    abstract::In forensics, mitochondrial DNA (mtDNA) analysis is foremost applied to rootless hairs often lacking detectable nuclear DNA. Sanger sequencing is the routine mtDNA method in most forensic laboratories, even though interpretation of mixed samples and heteroplasmic sites can be challenging. Individuals may hold cells wi...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111355

    authors: Gaag KJV,Desmyter S,Smit S,Prieto L,Sijen T

    更新日期:2020-11-16 00:00:00

  • Evolution of Oxidative Phosphorylation (OXPHOS) Genes Reflecting the Evolutionary and Life Histories of Fig Wasps (Hymenoptera, Chalcidoidea).

    abstract::Fig wasps are a peculiar group of insects which, for millions of years, have inhabited the enclosed syconia of fig trees. Considering the relatively closed and dark environment of fig syconia, we hypothesize that the fig wasps' oxidative phosphorylation (OXPHOS) pathway, which is the main oxygen consumption and adenos...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111353

    authors: Zhou Y,Huang D,Xin Z,Xiao J

    更新日期:2020-11-15 00:00:00

  • Germination-Arrest Bacillus subtilis Spores as An Oral Delivery Vehicle of Grass Carp Reovirus (GCRV) Vp7 Antigen Augment Protective Immunity in Grass Carp (Ctenopharyngodon idella).

    abstract::Oral vaccination is a practical method for the active immunization of farmed fish in the matter of animal welfare and handling costs. However, it always shows insufficient protective immunity, mainly due to antigen degradation in the gastrointestinal tract (GIT). Bacillus subtilis spores have been shown to be able to ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111351

    authors: Sun R,Zhang M,Chen H,Wei Y,Ning D

    更新日期:2020-11-14 00:00:00

  • Diverse Roles of MAX1 Homologues in Rice.

    abstract::Cytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111348

    authors: Marzec M,Situmorang A,Brewer PB,Brąszewska A

    更新日期:2020-11-13 00:00:00

  • Phased Haplotype Resolution of the SLC6A4 Promoter Using Long-Read Single Molecule Real-Time (SMRT) Sequencing.

    abstract::The SLC6A4 gene has been implicated in psychiatric disorder susceptibility and antidepressant response variability. The SLC6A4 promoter is defined by a variable number of homologous 20-24 bp repeats (5-HTTLPR), and long (L) and short (S) alleles are associated with higher and lower expression, respectively. However, t...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111333

    authors: Botton MR,Yang Y,Scott ER,Desnick RJ,Scott SA

    更新日期:2020-11-12 00:00:00

  • DNMTs and Impact of CpG Content, Transcription Factors, Consensus Motifs, lncRNAs, and Histone Marks on DNA Methylation.

    abstract::DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs' fun...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11111336

    authors: Loaeza-Loaeza J,Beltran AS,Hernández-Sotelo D

    更新日期:2020-11-12 00:00:00

  • Pharmacogenomics for Primary Care: An Overview.

    abstract::Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribed in primary care. ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11111337

    authors: Rollinson V,Turner R,Pirmohamed M

    更新日期:2020-11-12 00:00:00

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