Sequence Composition Underlying Centromeric and Heterochromatic Genome Compartments of the Pacific Oyster Crassostrea gigas.

abstract：:Propionibacteria have been studied extensively since the early 1930s due to their relevance to industry and importance as human pathogens. Still, their unique metabolism is far from fully understood. This is partly due to their signature high GC content, which has previously hampered the acquisition of quality sequenc...

journal_title：Genes

authors： McCubbin T,Gonzalez-Garcia RA,Palfreyman RW,Stowers C,Nielsen LK,Marcellin E

更新日期：2020-09-23 00:00:00

abstract：:In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...

journal_title：Genes

authors： Hadjadj L,Riziki T,Zhu Y,Li J,Diene SM,Rolain JM

更新日期：2017-12-19 00:00:00

abstract：:Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...

journal_title：Genes

authors： Zhang L,Feng S,Duan G,Li Y,Liu G

更新日期：2019-10-17 00:00:00

abstract：:Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...

journal_title：Genes

authors： Liu J,Bisseling T

更新日期：2020-07-11 00:00:00

abstract：:Monogenic forms of beta cell diabetes account for approximately 1%-2% of all cases of diabetes, yet remain underdiagnosed. Overlapping clinical features with common forms of diabetes, make diagnosis challenging. A genetic diagnosis of monogenic diabetes in many cases alters therapy, affects prognosis, enables genetic ...

journal_title：Genes

authors： Carroll RW,Murphy R

更新日期：2013-09-26 00:00:00

abstract：:Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85-90% reactivate telomerase, while 10-15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between b...

journal_title：Genes

authors： Armendáriz-Castillo I,López-Cortés A,García-Cárdenas J,Guevara-Ramírez P,Leone PE,Pérez-Villa A,Yumiceba V,Zambrano AK,Guerrero S,Paz-Y-Miño C

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:The recently discovered Methanonatronarchaeia are extremely halophilic and moderately thermophilic methyl-reducing methanogens representing a novel class-level lineage in the phylum Euryarchaeota related to the class Halobacteria. Here we present a detailed analysis of 1D-nano liquid chromatography-electrospray ioniza...

journal_title：Genes

authors： Ferrer M,Sorokin DY,Wolf YI,Ciordia S,Mena MC,Bargiela R,Koonin EV,Makarova KS

更新日期：2018-01-23 00:00:00

abstract：:DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies demonstrated that knoc...

journal_title：Genes

authors： Lai YH,Audira G,Liang ST,Siregar P,Suryanto ME,Lin HC,Villalobos O,Villaflores OB,Hao E,Lim KH,Hsiao CD

更新日期：2020-11-07 00:00:00

abstract：:The superior performance of hybrids to parents, termed heterosis, has been widely utilized in animal and plant breeding programs, but the molecular mechanism underlying heterosis remains an enigma. RNA-Seq provides a novel way to investigate heterosis at the transcriptome-wide level, because gene expression functions ...

journal_title：Genes

authors： Zhuo Z,Lamont SJ,Abasht B

更新日期：2019-01-07 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) signaling pathway plays key roles in sensing extracellular signals and transmitting them from the cell membrane to the nucleus in response to various environmental stimuli. A MAPKKK protein CgMck1 in Colletotrichum gloeosporioides was characterized. Phenotypic analyses of the ∆C...

journal_title：Genes

authors： Fang YL,Xia LM,Wang P,Zhu LH,Ye JR,Huang L

更新日期：2018-11-08 00:00:00

abstract：:Unbalanced dietary habits and gut dysmotility are causative factors in metabolic and functional gut disorders, including obesity, diabetes, and constipation. Reduction in luminal butyrate synthesis is known to be associated with gut dysbioses, and studies have suggested that restoring butyrate formation in the colon m...

journal_title：Genes

authors： Hwang N,Eom T,Gupta SK,Jeong SY,Jeong DY,Kim YS,Lee JH,Sadowsky MJ,Unno T

更新日期：2017-11-28 00:00:00

abstract：:Listeria monocytogenes is a major human foodborne pathogen that is prevalent in the natural environment and has a high case fatality rate. Whole genome sequencing (WGS) analysis has emerged as a valuable methodology for the classification of L. monocytogenes isolates and the identification of virulence islands that ma...

journal_title：Genes

authors： Hilliard A,Leong D,O'Callaghan A,Culligan EP,Morgan CA,DeLappe N,Hill C,Jordan K,Cormican M,Gahan CGM

更新日期：2018-03-20 00:00:00

abstract：:During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organ...

journal_title：Genes

authors： Reich S,Weinstein DC

更新日期：2019-11-06 00:00:00

abstract：:Winged bean (Psophocarpus tetragonolobus) is an herbaceous multipurpose legume grown in hot and humid countries as a pulse, vegetable (leaves and pods), or root tuber crop depending on local consumption preferences. In addition to its different nutrient-rich edible parts which could contribute to food and nutritional ...

journal_title：Genes

authors： Wong QN,Tanzi AS,Ho WK,Malla S,Blythe M,Karunaratne A,Massawe F,Mayes S

更新日期：2017-03-09 00:00:00

abstract：:We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...

journal_title：Genes

authors： Zafar S,Shahzad M,Ishaq R,Yousaf A,Shaikh RS,Akram J,Ahmed ZM,Riazuddin S

更新日期：2020-08-22 00:00:00

abstract：:Altered melanosome transport in melanocytes, resulting from variants in the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution in many species. In dogs, the MLPH gene corresponds to the D locus and two variants, c.-22G > A (d1) and c.705G > C (d2), leading to the dilution of coat colo...

journal_title：Genes

authors： Van Buren SL,Minor KM,Grahn RA,Mickelson JR,Grahn JC,Malvick J,Colangelo JR,Mueller E,Kuehnlein P,Kehl A

更新日期：2020-06-10 00:00:00

abstract：:Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fert...

journal_title：Genes

authors： Somers M,Olde Loohuis LM,Aukes MF,Pasaniuc B,de Visser KCL,Kahn RS,Sommer IE,Ophoff RA

更新日期：2017-05-04 00:00:00

abstract：:We set out to assess the NIH/3T3 cell proliferation activity of Arabidopsis oil body-expressed recombinant oleosin-hEGF-hEGF protein. Normally, human epidermal growth factor (hEGF) is purified through complex process, however, oleosin fusion technology provides an inexpensive and scalable platform for its purification...

journal_title：Genes

authors： Qiang W,Gao T,Lan X,Guo J,Noman M,Li Y,Guo Y,Kong J,Li H,Du L,Yang J

更新日期：2020-08-19 00:00:00

abstract：:The Zn(II)₂Cys₆ zinc cluster gene family is a subclass of zinc-finger proteins, which are transcriptional regulators involved in a wide variety of biological processes in fungi. We performed genome-wide identification and characterization of Zn(II)₂Cys₆ zinc-cluster gene (C6 zinc gene) family in Tolypocladiumguangdong...

journal_title：Genes

authors： Zhang C,Huang H,Deng W,Li T

更新日期：2019-02-26 00:00:00

abstract：:Lactobacillus ruminis is a commensal motile lactic acid bacterium living in the intestinal tract of humans and animals. Although a few genomes of L. ruminis were published, most of them were animal derived. To explore the genetic diversity and potential niche-specific adaptation changes of L. ruminis, in the current w...

journal_title：Genes

authors： Wang S,Yang B,Ross RP,Stanton C,Zhao J,Zhang H,Chen W

更新日期：2020-01-08 00:00:00

abstract：:PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...

journal_title：Genes

authors： Yvert T,Miyamoto-Mikami E,Tobina T,Shiose K,Kakigi R,Tsuzuki T,Takaragawa M,Ichinoseki-Sekine N,Pérez M,Kobayashi H,Tanaka H,Naito H,Fuku N

更新日期：2020-08-27 00:00:00

abstract：:Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extreme...

journal_title：Genes

authors： Wang X,Liu J,Wang P,deMello A,Feng L,Zhu X,Wen W,Kodzius R,Gong X

更新日期：2018-06-05 00:00:00

abstract：:The SLC6A4 gene has been implicated in psychiatric disorder susceptibility and antidepressant response variability. The SLC6A4 promoter is defined by a variable number of homologous 20-24 bp repeats (5-HTTLPR), and long (L) and short (S) alleles are associated with higher and lower expression, respectively. However, t...

journal_title：Genes

authors： Botton MR,Yang Y,Scott ER,Desnick RJ,Scott SA

更新日期：2020-11-12 00:00:00

abstract：:Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...

journal_title：Genes

authors： Renaud L,Silveira WAD,Hazard ES,Simpson J,Falcinelli S,Chung D,Carnevali O,Hardiman G

更新日期：2017-10-13 00:00:00

abstract：:Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...

journal_title：Genes

authors： Arruda PSS,Ferreira DC,Oliveira C,Venere PC

更新日期：2019-08-23 00:00:00

abstract：:Continuous cultures assure the invariability of environmental conditions and the metabolic state of cultured microorganisms, whereas batch-cultured cells undergo constant changes in nutrients availability. For that reason, continuous culture is sometimes employed in the whole transcriptome, whole proteome, or whole me...

journal_title：Genes

authors： Klim J,Zielenkiewicz U,Kurlandzka A,Kaczanowski S,Skoneczny M

更新日期：2020-11-27 00:00:00

abstract：:During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining (NHEJ) or sequence dependent by homology directed repair (HDR). Whereas NHEJ-based generation of gene knock-out is widely performed, the HDR-based knock-in of speci...

journal_title：Genes

authors： Gerlach M,Kraft T,Brenner B,Petersen B,Niemann H,Montag J

更新日期：2018-06-13 00:00:00

abstract：:Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...

journal_title：Genes

authors： Pewan SB,Otto JR,Huerlimann R,Budd AM,Mwangi FW,Edmunds RC,Holman BWB,Henry MLE,Kinobe RT,Adegboye OA,Malau-Aduli AEO

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...

journal_title：Genes

authors： Zhang Z,Conner J,Guo Y,Ozias-Akins P

更新日期：2020-09-12 00:00:00