Abstract:
:Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus images. Therefore, this paper presents a novel MA detection method based on a deep neural network with a multilayer attention mechanism for retinal fundus images. First, a series of equalization operations are performed to improve the quality of the fundus images. Then, based on the attention mechanism, multiple feature layers with obvious target features are fused to achieve preliminary MA detection. Finally, the spatial relationships between MAs and blood vessels are utilized to perform a secondary screening of the preliminary test results to obtain the final MA detection results. We evaluated the method on the IDRiD_VOC dataset, which was collected from the open IDRiD dataset. The results show that our method effectively improves the average accuracy and sensitivity of MA detection.
journal_name
Genes (Basel)journal_title
Genesauthors
Zhang L,Feng S,Duan G,Li Y,Liu Gdoi
10.3390/genes10100817subject
Has Abstractpub_date
2019-10-17 00:00:00issue
10issn
2073-4425pii
genes10100817journal_volume
10pub_type
杂志文章相关文献
Genes文献大全abstract::The anaerobic degradation of benzoate in bacteria involves the benzoyl-CoA central pathway. Azoarcus/Aromatoleum strains are a major group of anaerobic benzoate degraders, and the transcriptional regulation of the bzd genes was extensively studied in Azoarcus sp. CIB. In this work, we show that the bzdR regulatory gen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10070489
更新日期:2019-06-27 00:00:00
abstract::Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9020089
更新日期:2018-02-14 00:00:00
abstract::Biogerontological research highlighted a complex and dynamic connection between aging, health and longevity, partially determined by genetic factors. Multifunctional proteins with moonlighting features, by integrating different cellular activities in the space and time, may explain part of this complexity. Inositol Po...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020125
更新日期:2019-02-08 00:00:00
abstract::The transition from a dormant to a germinating seed represents a crucial developmental switch in the life cycle of a plant. Subsequent transition from a germinating seed to an autotrophic organism also requires a robust and multi-layered control. Seed germination and seedling growth are multistep processes, involving ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes12010052
更新日期:2020-12-31 00:00:00
abstract::Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is consider...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10120972
更新日期:2019-11-26 00:00:00
abstract::The southern elephant seal Mirounga leonina is the largest phocid seal and one of the two species of elephant seals. They are listed as 'least concern' by the International Union for Conservation of Nature (IUCN) Red List of Threatened Species 2015. Here, we have assembled the reference genome for M. leonina using the...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020160
更新日期:2020-02-03 00:00:00
abstract::Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85-90% reactivate telomerase, while 10-15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between b...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070834
更新日期:2020-07-21 00:00:00
abstract::Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telomere dysfunction an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050475
更新日期:2020-04-27 00:00:00
abstract::The facultative aerobic bacterium Escherichia coli adjusts its cell cycle to environmental conditions. Because of its lifestyle, the bacterium has to balance the use of oxygen with the potential lethal effects of its poisonous derivatives. Oxidative damages perpetrated by molecules such as hydrogen peroxide and supero...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110565
更新日期:2018-11-21 00:00:00
abstract::The liver plays a key role in metabolism and affects pig production. However, the functional annotation of noncoding regions of the pig liver remains poorly understood. We revealed the landscape of cis-regulatory elements and their functional characterization in pig liver. We identified 102,373 cis-regulatory elements...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050348
更新日期:2019-05-07 00:00:00
abstract::Adiponectin plays an important role in energy homeostasis and metabolism in mammalian adipose tissue. In this study, the relationship between adiponectin gene (ADIPOQ) haplotypes and variation in growth and carcass traits in New Zealand (NZ) Romney lambs was investigated using General Linear Models (GLMs). Eight haplo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8060160
更新日期:2017-06-12 00:00:00
abstract::Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10121009
更新日期:2019-12-04 00:00:00
abstract::Diploid Alnus glutinosa s. str. and autotetraploid A. rohlenae form a narrow hybrid zone in a study area in southern Serbia, which results in triploid hybrid formation. The vast majority of previous studies have been focused on studies of maternal plants, but the offspring resulting from their crossing have not been m...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070770
更新日期:2020-07-09 00:00:00
abstract::Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-gr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010044
更新日期:2019-12-30 00:00:00
abstract::The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120391
更新日期:2017-12-15 00:00:00
abstract::Ring chromosome 8 (r(8)) is one of the least frequent ring chromosomes. Usually, maternal chromosome 8 forms a ring, which can be lost from cells due to mitotic instability. The 8q24 region contains the imprinted KCNK9 gene, which is expressed from the maternal allele. Heterozygous KCNK9 mutations are associated with ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11121473
更新日期:2020-12-09 00:00:00
abstract::Maize kernel development is a complex biological process that involves the temporal and spatial expression of many genes and fine gene regulation at a transcriptional and post-transcriptional level, and microRNAs (miRNAs) play vital roles during this process. To gain insight into miRNA-mediated regulation of maize ker...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120385
更新日期:2017-12-14 00:00:00
abstract::Genetic dissection of yield components and seed mineral-nutrient is crucial for understanding plant physiological and biochemical processes and alleviate nutrient malnutrition. Sesame (Sesamum indicum L.) is an orphan crop that harbors rich allelic repertoire for seed mineral-nutrients. Here, we harness this wide dive...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101221
更新日期:2020-10-18 00:00:00
abstract::Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins' structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking the replication forks near the origins using two different origi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes4020198
更新日期:2013-04-17 00:00:00
abstract::Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This revi...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9030161
更新日期:2018-03-13 00:00:00
abstract::In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120394
更新日期:2017-12-19 00:00:00
abstract::Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11050587
更新日期:2020-05-25 00:00:00
abstract::The spectrum of modern horse populations encompasses populations with a long history of development in isolation and relatively recently formed types. To increase our understanding of the evolutionary history and provide information on how to optimally conserve or improve these populations with varying development and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060480
更新日期:2019-06-25 00:00:00
abstract::Despite worldwide prevention programs, the incidence for cutaneous melanoma is continuously increasing. Mucosal melanoma (MM) represents a rare but highly aggressive phenotype of common melanoma with predilection in the sinonasal system. Far away from ultraviolet sun exposure, the molecular mechanisms underlying tumor...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8120384
更新日期:2017-12-13 00:00:00
abstract::Excessive fat deposition in the hepatocytes, associated with excess dietary fat intake, was related to the occurrence of fatty livers in fish. miR-101b plays the important roles in controlling lipid metabolism, but the underlying mechanism at the post-transcriptional level remains unclear. The purpose of this study is...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080861
更新日期:2020-07-29 00:00:00
abstract::Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040347
更新日期:2020-03-25 00:00:00
abstract::White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010094
更新日期:2020-01-14 00:00:00
abstract::Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes3030461
更新日期:2012-07-26 00:00:00
abstract::Olfaction, which is mediated by olfactory receptor (OR) genes, is essential in the daily life of fish, especially in foraging. However, Chinese perch (Siniperca chuatsi) is believed to prey with reliance on vision and lateral sensation, but not on olfaction. Therefore, understanding the evolutionary dynamics of the Ch...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020178
更新日期:2019-02-25 00:00:00
abstract::Recent advances in next-generation sequencing technology have led to the production of an unprecedented volume of genomic data, thus further advancing our understanding of the role of genetic variation in clinical pharmacogenomics. In the present study, we used whole exome sequencing data from 50,726 participants, as ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050561
更新日期:2020-05-18 00:00:00