Abstract：
:One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengthening of telomeres (ALT) pathway. Here, we review the phenotypes and molecular markers specific to ALT, and investigate the significance of telomere mutations and sequence variation in ALT cell lines. We also look at the recent advancements in understanding the different mechanisms behind ALT telomere elongation and finally, the progress made in identifying potential ALT-targeted therapies, including those already in use for the treatment of both hematological and solid tumors.
journal_name
Genes (Basel)journal_title
Genesauthors
Sommer A,Royle NJdoi
10.3390/genes11020133subject
Has Abstractpub_date
2020-01-27 00:00:00issue
2issn
2073-4425pii
genes11020133journal_volume
11pub_type
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