NetR and AttR, Two New Bioinformatic Tools to Integrate Diverse Datasets into Cytoscape Network and Attribute Files.

abstract：:Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alte...

journal_title：Genes

authors： Salmoiraghi S,Cavagna R,Guinea Montalvo ML,Ubiali G,Tosi M,Peruta B,Intermesoli T,Oldani E,Salvi A,Pavoni C,Giussani U,Bassan R,Rambaldi A,Spinelli O

更新日期：2020-08-20 00:00:00

abstract：:Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...

journal_title：Genes

authors： Lima AR,Santos L,Correia M,Soares P,Sobrinho-Simões M,Melo M,Máximo V

更新日期：2018-02-21 00:00:00

abstract：:The grizzly bear (Ursus arctos ssp. horribilis) represents the largest population of brown bears in North America. Its genome was sequenced using a microfluidic partitioning library construction technique, and these data were supplemented with sequencing from a nanopore-based long read platform. The final assembly was...

journal_title：Genes

authors： Taylor GA,Kirk H,Coombe L,Jackman SD,Chu J,Tse K,Cheng D,Chuah E,Pandoh P,Carlsen R,Zhao Y,Mungall AJ,Moore R,Birol I,Franke M,Marra MA,Dutton C,Jones SJM

更新日期：2018-11-30 00:00:00

abstract：:Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

journal_title：Genes

authors： Boeger H,Shelansky R,Patel H,Brown CR

更新日期：2015-06-30 00:00:00

abstract：:DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs' fun...

journal_title：Genes

authors： Loaeza-Loaeza J,Beltran AS,Hernández-Sotelo D

更新日期：2020-11-12 00:00:00

abstract：:The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are...

journal_title：Genes

authors： Ghanemi A,Melouane A,Yoshioka M,St-Amand J

更新日期：2020-07-31 00:00:00

abstract：:The conserved Notch pathway is reported to be involved in progesterone synthesis and secretion; however, the exact effects remain controversial. To determine the role and potential mechanisms of the Notch signaling pathway in progesterone biosynthesis in porcine granulosa cells (pGCs), we first used a pharmacological ...

journal_title：Genes

authors： Guo R,Chen F,Shi Z

更新日期：2020-01-22 00:00:00

abstract：:Monogenic forms of beta cell diabetes account for approximately 1%-2% of all cases of diabetes, yet remain underdiagnosed. Overlapping clinical features with common forms of diabetes, make diagnosis challenging. A genetic diagnosis of monogenic diabetes in many cases alters therapy, affects prognosis, enables genetic ...

journal_title：Genes

authors： Carroll RW,Murphy R

更新日期：2013-09-26 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome that results from dominant loss-of-function mutations mainly in the NF1 gene. Large rearrangements are present in 5-10% of affected patients, generally encompass NF1 neighboring genes, and are correlated with a more severe NF1 phenotype. Evident genoty...

journal_title：Genes

authors： Brussa Reis L,Turchetto-Zolet AC,Fonini M,Ashton-Prolla P,Rosset C

更新日期：2019-10-24 00:00:00

abstract：:Although bacterial genomes have been traditionally viewed as being very compact, with relatively low amounts of repetitive and non-coding DNA, this view has dramatically changed in recent years. The increase of available complete bacterial genomes has revealed that many species present abundant repetitive DNA (i.e., i...

journal_title：Genes

authors： Gil R,Latorre A

更新日期：2012-10-12 00:00:00

abstract：:Bacterial fruit blotch (BFB) causes losses in melon marketable yield. However, until now, there has been no information about the genetic loci responsible for resistance to the disease or their pattern of inheritance. We determined the inheritance pattern of BFB resistance from a segregating population of 491 F2 indiv...

journal_title：Genes

authors： Islam MR,Hossain MR,Jesse DMI,Jung HJ,Kim HT,Park JI,Nou IS

更新日期：2020-02-19 00:00:00

abstract：:We analysed nine microsatellite markers for 626 individuals representing the geographic range of eight closely related endemic New Zealand species of Sophora. Structure analysis identified the optimal K value as seven, with samples identified as Sophorachathamica, Sophorafulvida, Sophoralongicarinata, and Sophoraprost...

journal_title：Genes

authors： Heenan P,Mitchell C,Houliston G

更新日期：2018-02-20 00:00:00

abstract：:Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...

journal_title：Genes

authors： Demars J,Iannuccelli N,Utzeri VJ,Auvinet G,Riquet J,Fontanesi L,Allain D

更新日期：2018-08-23 00:00:00

abstract：:Drosophila melanogaster is one of the most extensively used genetic model organisms for studying LTR retrotransposons that are represented by various groups in its genome. However, the phenomenon of molecular domestication of LTR retrotransposons has been insufficiently studied in Drosophila, as well as in other inver...

journal_title：Genes

authors： Makhnovskii P,Balakireva Y,Nefedova L,Lavrenov A,Kuzmin I,Kim A

更新日期：2020-04-06 00:00:00

abstract：:Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

journal_title：Genes

authors： Gimenez E,Manzano-Agugliaro F

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...

journal_title：Genes

authors： Liu H,Li Q,Xing Y

更新日期：2018-10-10 00:00:00

abstract：:The continuous development of new genotyping technologies requires awareness of their potential advantages and limitations concerning utility for pharmacogenomics (PGx). In this review, we provide an overview of technologies that can be applied in PGx research and clinical practice. Most commonly used are single nucle...

journal_title：Genes

authors： van der Lee M,Kriek M,Guchelaar HJ,Swen JJ

更新日期：2020-12-04 00:00:00

abstract：:Illumina and nanopore sequencing technologies are powerful tools that can be used to determine the bacterial composition of complex microbial communities. In this study, we compared nasal microbiota results at genus level using both Illumina and nanopore 16S rRNA gene sequencing. We also monitored the progression of n...

journal_title：Genes

authors： Heikema AP,Horst-Kreft D,Boers SA,Jansen R,Hiltemann SD,de Koning W,Kraaij R,de Ridder MAJ,van Houten CB,Bont LJ,Stubbs AP,Hays JP

更新日期：2020-09-21 00:00:00

abstract：:Gene doping, an activity which abuses and misuses gene therapy, is a major concern in sports and horseracing industries. Effective methods capable of detecting and monitoring gene doping are urgently needed. Although several PCR-based methods that detect transgenes have been developed, many of them focus only on a sin...

journal_title：Genes

authors： Tozaki T,Ohnuma A,Kikuchi M,Ishige T,Kakoi H,Hirota KI,Kusano K,Nagata SI

更新日期：2020-04-23 00:00:00

abstract：:Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telomere dysfunction an...

journal_title：Genes

authors： M'kacher R,Colicchio B,Borie C,Junker S,Marquet V,Heidingsfelder L,Soehnlen K,Najar W,Hempel WM,Oudrhiri N,Wilhelm-Murer N,Miguet M,Arnoux M,Ferrapie C,Kerbrat W,Plesch A,Dieterlen A,Girinsky T,Voisin P,Deschenes G

更新日期：2020-04-27 00:00:00

abstract：:Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...

journal_title：Genes

authors： Moura J,Børsheim E,Carvalho E

更新日期：2014-09-29 00:00:00

abstract：:Old World lupins constitute an interesting model for evolutionary research due to diversity in genome size and chromosome number, indicating evolutionary genome reorganization. It has been hypothesized that the polyploidization event which occurred in the common ancestor of the Fabaceae family was followed by a lineag...

journal_title：Genes

authors： Bielski W,Książkiewicz M,Šimoníková D,Hřibová E,Susek K,Naganowska B

更新日期：2020-12-10 00:00:00

abstract：:Since ancient times, the importance of physical activity (PA) and of a wholesome diet for human health has been clearly recognized. However, only recently, it has been acknowledged that PA can reverse at least some of the unwanted effects of a sedentary lifestyle, contributing to the treatment of pathologies such as h...

journal_title：Genes

authors： Di Liegro I

更新日期：2019-12-16 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...

journal_title：Genes

authors： Umer S,Zhao SJ,Sammad A,Weldegebriall Sahlu B,Yunwei P,Zhu H

更新日期：2019-12-04 00:00:00

abstract：:During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building upon past theoretical work and the continued development of quantitat...

journal_title：Genes

authors： Schilling MP,Mullen SP,Kronforst M,Safran RJ,Nosil P,Feder JL,Gompert Z,Flaxman SM

更新日期：2018-05-24 00:00:00

abstract：:Epigenetic alterations at imprinted genes on different chromosomes have been linked to several imprinting disorders (IDs) such as Beckwith-Wiedemann syndrome (BWS) and pseudohypoparathyroidism type 1b (PHP1b). Here, we present a male patient with these two distinct IDs caused by two independent mechanisms-loss of meth...

journal_title：Genes

authors： Choufani S,Ko JM,Lou Y,Shuman C,Fishman L,Weksberg R

更新日期：2021-01-27 00:00:00

abstract：:The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...

journal_title：Genes

authors： Geng MT,Min Y,Yao Y,Chen X,Fan J,Yuan S,Wang L,Sun C,Zhang F,Shang L,Wang YL,Li RM,Fu SP,Duan RJ,Liu J,Hu XW,Guo JC

更新日期：2017-12-15 00:00:00

abstract：:There is an ongoing worldwide coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, confirmatory diagnosis is by reverse transcription polymerase chain reaction (RT-PCR), typically taking several hours and requiring a molecular laboratory to pe...

journal_title：Genes

authors： Wee SK,Sivalingam SP,Yap EPH

更新日期：2020-06-18 00:00:00

abstract：:We studied and compared the nucleolar expression or nucleoli from specific bivalents in spermatocytes of the standard Mus musculus domesticus 2n=40, of Robertsonian (Rb) homozygotes 2n = 24 and heterozygotes 2n = 32. We analyzed 200 nuclear microspreads of each specific nucleolar chromosome and spermatocyte karyotype,...

journal_title：Genes

authors： López-Moncada F,Tapia D,Zuñiga N,Ayarza E,López-Fenner J,Redi CA,Berríos S

更新日期：2019-02-06 00:00:00