Proteomic Analysis of Methanonatronarchaeum thermophilum AMET1, a Representative of a Putative New Class of Euryarchaeota, "Methanonatronarchaeia".

abstract：:Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyzed the right-ventricular systolic pressure (RVSP), right-ventricular hypertrophy (RVH), lung histology, and transcriptomes of six-week-old male rats with PH induced by (1) hypoxia (HO), (2) administration of monocrotalin...

journal_title：Genes

authors： Mathew R,Huang J,Iacobas S,Iacobas DA

更新日期：2020-01-23 00:00:00

abstract：:While the number of mammalian genome assemblies has proliferated, Y-chromosome assemblies have lagged behind. This discrepancy is caused by biological features of the Y-chromosome, such as its high repeat content, that present challenges to assembly with short-read, next-generation sequencing technologies. Partial Y-c...

journal_title：Genes

authors： Rando HM,Wadlington WH,Johnson JL,Stutchman JT,Trut LN,Farré M,Kukekova AV

更新日期：2019-05-28 00:00:00

abstract：:Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...

journal_title：Genes

authors： Badji A,Kwemoi DB,Machida L,Okii D,Mwila N,Agbahoungba S,Kumi F,Ibanda A,Bararyenya A,Solemanegy M,Odong T,Wasswa P,Otim M,Asea G,Ochwo-Ssemakula M,Talwana H,Kyamanywa S,Rubaihayo P

更新日期：2020-06-24 00:00:00

abstract：:Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...

journal_title：Genes

authors： Yin Z,Han X,Li Y,Wang J,Wang D,Wang S,Fu X,Ye W

更新日期：2017-12-05 00:00:00

abstract：:Continuous cultures assure the invariability of environmental conditions and the metabolic state of cultured microorganisms, whereas batch-cultured cells undergo constant changes in nutrients availability. For that reason, continuous culture is sometimes employed in the whole transcriptome, whole proteome, or whole me...

journal_title：Genes

authors： Klim J,Zielenkiewicz U,Kurlandzka A,Kaczanowski S,Skoneczny M

更新日期：2020-11-27 00:00:00

abstract：:The grizzly bear (Ursus arctos ssp. horribilis) represents the largest population of brown bears in North America. Its genome was sequenced using a microfluidic partitioning library construction technique, and these data were supplemented with sequencing from a nanopore-based long read platform. The final assembly was...

journal_title：Genes

authors： Taylor GA,Kirk H,Coombe L,Jackman SD,Chu J,Tse K,Cheng D,Chuah E,Pandoh P,Carlsen R,Zhao Y,Mungall AJ,Moore R,Birol I,Franke M,Marra MA,Dutton C,Jones SJM

更新日期：2018-11-30 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...

journal_title：Genes

authors： Zhu X,Li HD,Xu Y,Guo L,Wu FX,Duan G,Wang J

更新日期：2019-01-29 00:00:00

abstract：:Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in t...

journal_title：Genes

authors： Pereira J,Santos M,Delabio R,Barbosa M,Smith M,Payão S,Rasmussen L

更新日期：2020-04-05 00:00:00

abstract：:Listeria monocytogenes is a major human foodborne pathogen that is prevalent in the natural environment and has a high case fatality rate. Whole genome sequencing (WGS) analysis has emerged as a valuable methodology for the classification of L. monocytogenes isolates and the identification of virulence islands that ma...

journal_title：Genes

authors： Hilliard A,Leong D,O'Callaghan A,Culligan EP,Morgan CA,DeLappe N,Hill C,Jordan K,Cormican M,Gahan CGM

更新日期：2018-03-20 00:00:00

abstract：:White mold (WM) is a devastating fungal disease affecting common bean (Phaseolus vulgaris L.). In this research, a genome-wide association study (GWAS) for WM resistance was conducted using 294 lines of the Spanish diversity panel. One single-locus method and six multi-locus methods were used in the GWAS. Response to ...

journal_title：Genes

authors： Campa A,García-Fernández C,Ferreira JJ

更新日期：2020-12-12 00:00:00

abstract：:DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs' fun...

journal_title：Genes

authors： Loaeza-Loaeza J,Beltran AS,Hernández-Sotelo D

更新日期：2020-11-12 00:00:00

abstract：:PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...

journal_title：Genes

authors： Yvert T,Miyamoto-Mikami E,Tobina T,Shiose K,Kakigi R,Tsuzuki T,Takaragawa M,Ichinoseki-Sekine N,Pérez M,Kobayashi H,Tanaka H,Naito H,Fuku N

更新日期：2020-08-27 00:00:00

abstract：:In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction with chemically synthesized sgRNAs and pegRNAs for efficient editing of human i...

journal_title：Genes

authors： Sürün D,Schneider A,Mircetic J,Neumann K,Lansing F,Paszkowski-Rogacz M,Hänchen V,Lee-Kirsch MA,Buchholz F

更新日期：2020-05-06 00:00:00

abstract：:Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...

journal_title：Genes

authors： Xia X

更新日期：2020-08-25 00:00:00

abstract：:Acquisition of mobile elements by horizontal gene transfer can play a major role in bacterial adaptation and genome evolution by providing traits that contribute to bacterial fitness. However, gaining foreign DNA can also impose significant fitness costs to the host bacteria and can even produce detrimental effects. T...

journal_title：Genes

authors： Piña-Iturbe A,Suazo ID,Hoppe-Elsholz G,Ulloa-Allendes D,González PA,Kalergis AM,Bueno SM

更新日期：2020-01-29 00:00:00

abstract：:Root nodule symbioses (nodulation) and whole genome duplication (WGD, polyploidy) are both important phenomena in the legume family (Leguminosae). Recently, it has been proposed that polyploidy may have played a critical role in the origin or refinement of nodulation. However, while nodulation and polyploidy have been...

journal_title：Genes

authors： Powell AF,Doyle JJ

更新日期：2017-11-30 00:00:00

abstract：:The mutation parameter θ is fundamental and ubiquitous in the analysis of population samples of DNA sequences. This paper presents a new highly efficient estimator of θ by utilizing the phylogenetic information among distinct alleles in a sample of DNA sequences. The new estimator, called Allelic BLUE, is derived from...

journal_title：Genes

authors： Fu Y

更新日期：2014-07-22 00:00:00

abstract：:Protein sequence, structure, and function are inherently linked through evolution and population genetics. Our knowledge of protein structure comes from solved structures in the Protein Data Bank (PDB), our knowledge of sequence through sequences found in the NCBI sequence databases (http://www.ncbi.nlm.nih.gov/), and...

journal_title：Genes

authors： Siltberg-Liberles J,Grahnen JA,Liberles DA

更新日期：2011-10-28 00:00:00

abstract：:MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...

journal_title：Genes

authors： Bardot B,Toledo F

更新日期：2017-02-20 00:00:00

abstract：:Genetic adaptation to extremes is a fascinating topic. Nevertheless, few studies have explored the genetic adaptation of closely related species respectively inhabiting distinct extremes. With deep transcriptome sequencing, we attempt to detect the genetic architectures of tadpoles of five closely related toad species...

journal_title：Genes

authors： Chang L,Zhu W,Shi S,Zhang M,Jiang J,Li C,Xie F,Wang B

更新日期：2020-01-22 00:00:00

abstract：:The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the en...

journal_title：Genes

authors： Gosalia N,Harris A

更新日期：2015-07-13 00:00:00

abstract：:In the years since the first complete human genome sequence was reported, there has been a rapid development of technologies to facilitate high-throughput sequence analysis of DNA (termed "next-generation" sequencing). These novel approaches to DNA sequencing offer the promise of complete genomic analysis at a cost fe...

journal_title：Genes

authors： Anderson MW,Schrijver I

更新日期：2010-05-25 00:00:00

abstract：:The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal ...

journal_title：Genes

authors： Baker Frost D,da Silveira W,Hazard ES,Atanelishvili I,Wilson RC,Flume J,Day KL,Oates JC,Bogatkevich GS,Feghali-Bostwick C,Hardiman G,Ramos PS

更新日期：2021-01-20 00:00:00

abstract：:Gene expression in the brain is dramatically regulated by a variety of stimuli. While the role of neural activity has been extensively studied, less is known about the effects of metabolism and nutrition on transcriptional control mechanisms in the brain. Extracellular signals are integrated at the chromatin level thr...

journal_title：Genes

authors： Pizzorusso T,Tognini P

更新日期：2020-07-03 00:00:00

abstract：:Vitellogenin receptors (VgRs) play critical roles in egg formation by transporting vitellogenin (Vg) into oocytes in insects. Although the function of VgR in insects is well studied, the transcriptional regulation of this gene is still unclear. Here, we cloned the promoter of the VgR gene from Bombyx mori (BmVgR), and...

journal_title：Genes

authors： Shen G,Chen E,Ji X,Liu L,Liu J,Hua X,Li D,Xiao Y,Xia Q

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:coalescence methods have emerged as a popular alternative for inferring species trees with large genomic datasets, because these methods explicitly account for incomplete lineage sorting. However, statistical consistency of summary coalescence methods is not guaranteed unless several model assumptions are true, includ...

journal_title：Genes

authors： Springer MS,Gatesy J

更新日期：2018-02-26 00:00:00

abstract：:The woody Sonchus alliance consists primarily of woody species of the genus Sonchus (subgenus Dendrosonchus; family Asteraceae). Most members of the alliance are endemic to the oceanic archipelagos in the phytogeographic region of Macaronesia. They display extensive morphological, ecological, and anatomical diversity,...

journal_title：Genes

authors： Cho MS,Yang JY,Yang TJ,Kim SC

更新日期：2019-03-14 00:00:00

abstract：:White spot syndrome virus (WSSV), one of the major pathogens of Procambarus clarkii, has caused severe disruption to the aquaculture industry of P. clarkii in China. To reveal the gene regulatory mechanisms underlying WSSV infection, a comparative transcriptome analysis was performed among WSSV-infected susceptible in...

journal_title：Genes

authors： Yi S,Li Y,Shi L,Zhang L

更新日期：2017-11-10 00:00:00

abstract：:Altered melanosome transport in melanocytes, resulting from variants in the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution in many species. In dogs, the MLPH gene corresponds to the D locus and two variants, c.-22G > A (d1) and c.705G > C (d2), leading to the dilution of coat colo...

journal_title：Genes

authors： Van Buren SL,Minor KM,Grahn RA,Mickelson JR,Grahn JC,Malvick J,Colangelo JR,Mueller E,Kuehnlein P,Kehl A

更新日期：2020-06-10 00:00:00