当前位置： SCI文献检索 > Genes期刊下所有文献 > Chromatin Dynamics in the Regulation of CFTR Expression.

Chromatin Dynamics in the Regulation of CFTR Expression.

Abstract：

:The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the entire human genome have greatly facilitated these studies. In this review we describe the complex machinery of tissue-specific regulation of CFTR expression, and put earlier observations in context by incorporating them into datasets generated by the most recent genomics methods. Though the gene promoter is required for CFTR expression, cell-type specific regulatory elements are located elsewhere in the gene and in flanking intergenic regions. Probably within its own topological domain established by the architectural proteins CTCF and cohesin, the CFTR locus utilizes chromatin dynamics to remodel nucleosomes, recruit cell-selective transcription factors, and activate intronic enhancers. These cis-acting elements are then brought to the gene promoter by chromatin looping mechanisms, which establish long-range interactions across the locus. Despite its complexity, the CFTR locus provides a paradigm for elucidating the critical role of chromatin dynamics in the transcription of individual human genes.

journal_name

Genes (Basel)

journal_title

Genes

authors

Gosalia N,Harris A

doi

10.3390/genes6030543

subject

Has Abstract

pub_date

2015-07-13 00:00:00

pages

543-58

issue

3

issn

2073-4425

pii

genes6030543

journal_volume

6

pub_type

杂志文章,评审

相关文献

Genes文献大全
  • A Hybrid Clustering Algorithm for Identifying Cell Types from Single-Cell RNA-Seq Data.

    abstract：:Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10020098

    authors： Zhu X,Li HD,Xu Y,Guo L,Wu FX,Duan G,Wang J

    更新日期：2019-01-29 00:00:00

  • Evolution of NIN and NIN-like Genes in Relation to Nodule Symbiosis.

    abstract：:Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes11070777

    authors： Liu J,Bisseling T

    更新日期：2020-07-11 00:00:00

  • Study of the Relationship between Polymorphisms in the IL-8 Gene Promoter Region and Coccidiosis Resistance Index in Jinghai Yellow Chickens.

    abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11050476

    authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

    更新日期：2020-04-27 00:00:00

  • Clinical Characteristics and In Vitro Analysis of MYO6 Variants Causing Late-Onset Progressive Hearing Loss.

    abstract：:MYO6 is known as a genetic cause of autosomal dominant and autosomal recessive inherited hearing loss. In this study, to clarify the frequency and clinical characteristics of hearing loss caused by MYO6 gene mutations, a large-scale genetic analysis of Japanese patients with hearing loss was performed. By means of mas...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11030273

    authors： Oka SI,Day TF,Nishio SY,Moteki H,Miyagawa M,Morita S,Izumi S,Ikezono T,Abe S,Nakayama J,Hyogo M,Okamoto N,Uehara N,Oshikawa C,Kitajiri SI,Usami SI

    更新日期：2020-03-04 00:00:00

  • Identification of Genetic Locus Underlying Easy Dehulling in Rice-Tartary for Easy Postharvest Processing of Tartary Buckwheat.

    abstract：:As a highly nutritious crop, Tartary buckwheat (Fagopyrum tartaricum) strongly adapts and grows in adverse environments and is widely grown in Asia. However, its flour contains a large proportion of the hull that adheres to the testa layer of the groats and is difficult to be removed in industrial processing. Fortunat...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11040459

    authors： Zhang L,Ma M,Liu L

    更新日期：2020-04-23 00:00:00

  • Heat Stress Impairs the Physiological Responses and Regulates Genes Coding for Extracellular Exosomal Proteins in Rat.

    abstract：:Heat stress (HS) is challenging in humans and animals as it is a complicated regulatory mechanism. This prompted us to characterize the physiological and molecular responses of a HS-animal model. In this study, a rat model system was developed by using three temperature treatments (40 ℃, 42 ℃, and 43 ℃) and sixteen bi...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11030306

    authors： Dou J,Khan A,Khan MZ,Mi S,Wang Y,Yu Y,Wang Y

    更新日期：2020-03-13 00:00:00

  • The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

    abstract：:Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear how the individual genotypes contribute to the estimated 250 million chronic HBV infections. We performed a literature search on HBV genotyping data throughout the world. Over 900 publications were assessed and data were extr...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9100495

    authors： Velkov S,Ott JJ,Protzer U,Michler T

    更新日期：2018-10-15 00:00:00

  • B Chromosomes in the Drosophila Genus.

    abstract：:Our current knowledge of B chromosome biology has been augmented by an increase in the number and diversity of species observed to carry B chromosomes as well as the use of next-generation sequencing for B chromosome genomic analysis. Within the genus Drosophila, B chromosomes have been observed in a handful of specie...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9100470

    authors： Hanlon SL,Hawley RS

    更新日期：2018-09-27 00:00:00

  • Regulation of the X Chromosome in the Germline and Soma of Drosophila melanogaster Males.

    abstract：:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9050242

    authors： Argyridou E,Parsch J

    更新日期：2018-05-04 00:00:00

  • Marker-Assisted Gene Pyramiding and the Reliability of Using SNP Markers Located in the Recombination Suppressed Regions of Sunflower (Helianthus annuus L.).

    abstract：:Rust caused by the fungus Puccinia helianthi and downy mildew (DM) caused by the obligate pathogen Plasmopara halstedii are two of the most globally important sunflower diseases. Resistance to rust and DM is controlled by race-specific single dominant genes. The present study aimed at pyramiding rust resistance genes ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11010010

    authors： Qi L,Ma G

    更新日期：2019-12-20 00:00:00

  • Efficient Knock-in of a Point Mutation in Porcine Fibroblasts Using the CRISPR/Cas9-GMNN Fusion Gene.

    abstract：:During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining (NHEJ) or sequence dependent by homology directed repair (HDR). Whereas NHEJ-based generation of gene knock-out is widely performed, the HDR-based knock-in of speci...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9060296

    authors： Gerlach M,Kraft T,Brenner B,Petersen B,Niemann H,Montag J

    更新日期：2018-06-13 00:00:00

  • Transcriptome Analysis Reveals Long Intergenic Noncoding RNAs Contributed to Growth and Meat Quality Differences between Yorkshire and Wannanhua Pig.

    abstract：:There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8080203

    authors： Zou C,Li S,Deng L,Guan Y,Chen D,Yuan X,Xia T,He X,Shan Y,Li C

    更新日期：2017-08-18 00:00:00

  • A Third MLPH Variant Causing Coat Color Dilution in Dogs.

    abstract：:Altered melanosome transport in melanocytes, resulting from variants in the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution in many species. In dogs, the MLPH gene corresponds to the D locus and two variants, c.-22G > A (d1) and c.705G > C (d2), leading to the dilution of coat colo...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11060639

    authors： Van Buren SL,Minor KM,Grahn RA,Mickelson JR,Grahn JC,Malvick J,Colangelo JR,Mueller E,Kuehnlein P,Kehl A

    更新日期：2020-06-10 00:00:00

  • Comparative Analysis of Cotton Small RNAs and Their Target Genes in Response to Salt Stress.

    abstract：:Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8120369

    authors： Yin Z,Han X,Li Y,Wang J,Wang D,Wang S,Fu X,Ye W

    更新日期：2017-12-05 00:00:00

  • Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype.

    abstract：:Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmo...

    journal_title：Genes

    pub_type：

    doi：10.3390/genes7120108

    authors： Skauli N,Wallace S,Chiang SC,Barøy T,Holmgren A,Stray-Pedersen A,Bryceson YT,Strømme P,Frengen E,Misceo D

    更新日期：2016-11-29 00:00:00

  • DNA Damage Repair System in Plants: A Worldwide Research Update.

    abstract：:Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes8110299

    authors： Gimenez E,Manzano-Agugliaro F

    更新日期：2017-10-30 00:00:00

  • Fitness Costs of the Glutathione S-Transferase Epsilon 2 (L119F-GSTe2) Mediated Metabolic Resistance to Insecticides in the Major African Malaria Vector Anopheles Funestus.

    abstract：:Metabolic resistance to insecticides threatens malaria control. However, little is known about its fitness cost in field populations of malaria vectors, thus limiting the design of suitable resistance management strategies. Here, we assessed the association between the glutathione S-transferase GSTe2-mediated metaboli...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9120645

    authors： Tchouakui M,Riveron JM,Djonabaye D,Tchapga W,Irving H,Soh Takam P,Njiokou F,Wondji CS

    更新日期：2018-12-19 00:00:00

  • miR-194 Accelerates Apoptosis of Aβ1⁻42-Transduced Hippocampal Neurons by Inhibiting Nrn1 and Decreasing PI3K/Akt Signaling Pathway Activity.

    abstract：:This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10040313

    authors： Wang T,Cheng Y,Han H,Liu J,Tian B,Liu X

    更新日期：2019-04-21 00:00:00

  • The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses.

    abstract：:Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is involved in DNA repair pathways as it mends the topoisomerase I-DNA covalent complexes. In plants, a small Tdp1 gene family, composed by Tdp1α and Tdp1β genes, was identified, but the roles of these genes in abiotic stress responses are not fully understood. To investigate the...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8110305

    authors： Sabatini ME,Pagano A,Araùjo S,Balestrazzi A,Macovei A

    更新日期：2017-11-03 00:00:00

  • Constructing the Microbial Association Network from Large-Scale Time Series Data Using Granger Causality.

    abstract：:The increasing availability of large-scale time series data allows the inference of microbial community dynamics by association network analysis. However, correlation-based association network analyses are noninformative of causal, mediating and time-dependent relationships between microbial community functional facto...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10030216

    authors： Ai D,Li X,Liu G,Liang X,Xia LC

    更新日期：2019-03-14 00:00:00

  • PupStruct: Prediction of Pupylated Lysine Residues Using Structural Properties of Amino Acids.

    abstract：:Post-translational modification (PTM) is a critical biological reaction which adds to the diversification of the proteome. With numerous known modifications being studied, pupylation has gained focus in the scientific community due to its significant role in regulating biological processes. The traditional experimenta...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11121431

    authors： Singh V,Sharma A,Dehzangi A,Tsunoda T

    更新日期：2020-11-28 00:00:00

  • Genetic Diversity, Population Structure, and Parentage Analysis of Croatian Grapevine Germplasm.

    abstract：:Croatian viticulture was most extensive at the beginning of the 20th century, when about 400 varieties were in use. Autochthonous varieties are the result of spontaneous hybridization from the pre-phylloxera era and are still cultivated today on about 35 % of vineyard area, while some exist only in repositories. We pr...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11070737

    authors： Žulj Mihaljević M,Maletić E,Preiner D,Zdunić G,Bubola M,Zyprian E,Pejić I

    更新日期：2020-07-02 00:00:00

  • Target-Genes Reveal Species and Genotypic Specificity of Anthocyanin Pigmentation in Citrus and Related Genera.

    abstract：BACKGROUND:Anthocyanin pigmentation characterizes a number of tissues of Citrus and its relatives. The gain and loss of pigmentation is intriguing and is inherited variously among species. METHODS:Citrus germplasm was used to investigate the anthocyanin pigmentation of tissues never before considered, including stamen...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11070807

    authors： Catalano C,Ciacciulli A,Salonia F,Russo MP,Caruso P,Caruso M,Russo G,Distefano G,Licciardello C

    更新日期：2020-07-16 00:00:00

  • Pipeline for the Rapid Development of Cytogenetic Markers Using Genomic Data of Related Species.

    abstract：:Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping us...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10020113

    authors： Kroupin P,Kuznetsova V,Romanov D,Kocheshkova A,Karlov G,Dang TX,Khuat TML,Kirov I,Alexandrov O,Polkhovskiy A,Razumova O,Divashuk M

    更新日期：2019-02-01 00:00:00

  • Haploidy in Tobacco Induced by PsASGR-BBML Transgenes via Parthenogenesis.

    abstract：BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11091072

    authors： Zhang Z,Conner J,Guo Y,Ozias-Akins P

    更新日期：2020-09-12 00:00:00

  • ALT: A Multi-Faceted Phenomenon.

    abstract：:One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengt...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes11020133

    authors： Sommer A,Royle NJ

    更新日期：2020-01-27 00:00:00

  • The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing.

    abstract：:Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes5040926

    authors： Moura J,Børsheim E,Carvalho E

    更新日期：2014-09-29 00:00:00

  • Dissecting Tissue-Specific Transcriptomic Responses from Leaf and Roots under Salt Stress in Petunia hybrida Mitchell.

    abstract：:One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affe...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8080195

    authors： Villarino GH,Hu Q,Scanlon MJ,Mueller L,Bombarely A,Mattson NS

    更新日期：2017-08-03 00:00:00

  • Association of XPC Gene Polymorphisms with Colorectal Cancer Risk in a Southern Chinese Population: A Case-Control Study and Meta-Analysis.

    abstract：:Xeroderma pigmentosum group C (XPC) is a key component of the nucleotide excision repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair capacity and further lead to genomic instability and carcinogenesis. Two common nonsynonymous polymorphisms in the XPC gene, Lys939Gln (rs2228001 A > C) a...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes7100073

    authors： Hua RX,Zhu J,Jiang DH,Zhang SD,Zhang JB,Xue WQ,Li XZ,Zhang PF,He J,Jia WH

    更新日期：2016-09-24 00:00:00

  • From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting.

    abstract：:Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes6030469

    authors： Boeger H,Shelansky R,Patel H,Brown CR

    更新日期：2015-06-30 00:00:00