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From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting.

Abstract：

:Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to "open" chromatin. In contradistinction to this static and deterministic view of the problem, a dynamical and probabilistic theory of promoter chromatin has emerged as its solution. This theory, which we review here, explains observed variation in promoter chromatin structure at the level of single gene molecules and provides a molecular basis for random bursting in transcription-the conjecture that promoters stochastically transition between transcriptionally conducive and inconducive states. The mechanism of transcriptional regulation may be understood only in probabilistic terms.

journal_name

Genes (Basel)

journal_title

Genes

authors

Boeger H,Shelansky R,Patel H,Brown CR

doi

10.3390/genes6030469

subject

Has Abstract

pub_date

2015-06-30 00:00:00

pages

469-83

issue

3

issn

2073-4425

pii

genes6030469

journal_volume

6

pub_type

杂志文章,评审

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