Abstract:
:In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to growth of duck skeletal muscle and explore the potential regulatory mechanism. RNA-seq technology was used to compare the transcriptome of skeletal muscles in black Muscovy ducks at different developmental stages (day 17, 21, 27, 31, and 34 of embryos and postnatal 6-month-olds). The SNPs and InDels of black Muscovy ducks at different growth stages were mainly in "INTRON", "SYNONYMOUS_CODING", "UTR_3_PRIME", and "DOWNSTREAM". The average number of AS in each sample was 37,267, mainly concentrated in TSS and TTS. Besides, a total of 19 to 5377 DEGs were detected in each pairwise comparison. Functional analysis showed that the DEGs were mainly involved in the processes of cell growth, muscle development, and cellular activities (junction, migration, assembly, differentiation, and proliferation). Many of DEGs were well known to be related to growth of skeletal muscle in black Muscovy duck, such as MyoG, FBXO1, MEF2A, and FoxN2. KEGG pathway analysis identified that the DEGs were significantly enriched in the pathways related to the focal adhesion, MAPK signaling pathway and regulation of the actin cytoskeleton. Some DEGs assigned to these pathways were potential candidate genes inducing the difference in muscle growth among the developmental stages, such as FAF1, RGS8, GRB10, SMYD3, and TNNI2. Our study identified several genes and pathways that may participate in the regulation of skeletal muscle growth in black Muscovy duck. These results should serve as an important resource revealing the molecular basis of muscle growth and development in duck.
journal_name
Genes (Basel)journal_title
Genesauthors
Hu Z,Cao J,Liu G,Zhang H,Liu Xdoi
10.3390/genes11101228subject
Has Abstractpub_date
2020-10-20 00:00:00issue
10issn
2073-4425pii
genes11101228journal_volume
11pub_type
杂志文章相关文献
Genes文献大全abstract::Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribed in primary care. ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11111337
更新日期:2020-11-12 00:00:00
abstract::Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7050020
更新日期:2016-05-13 00:00:00
abstract::Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minirevi...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9070340
更新日期:2018-07-06 00:00:00
abstract::Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-gr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010044
更新日期:2019-12-30 00:00:00
abstract::One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8080195
更新日期:2017-08-03 00:00:00
abstract::The complete mutational spectrum of dystrophinopathies and limb-girdle muscular dystrophy (LGMD) remains unknown in Mexican population. Seventy-two unrelated Mexican male patients (73% of pediatric age) with clinical suspicion of muscular dystrophy and no evidence of DMD gene deletion on multiplex polymerase chain rea...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110856
更新日期:2019-10-29 00:00:00
abstract::A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...]. ...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes11030245
更新日期:2020-02-26 00:00:00
abstract::The wall-associated kinase (WAK) and wall-associated kinase like (WAKL) is a subfamily of receptor-like kinases associated with the cell wall, which have been suggested as sensors of the extracellular environment and triggers of intracellular signals. However, these proteins have not yet been comprehensively analyzed ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101186
更新日期:2020-10-12 00:00:00
abstract::Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9020089
更新日期:2018-02-14 00:00:00
abstract::The spectrum of modern horse populations encompasses populations with a long history of development in isolation and relatively recently formed types. To increase our understanding of the evolutionary history and provide information on how to optimally conserve or improve these populations with varying development and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060480
更新日期:2019-06-25 00:00:00
abstract::Cancer is the second deadliest disease listed by the WHO. One of the major causes of cancer disease is tobacco and consumption possibly due to its main component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). A plethora of studies have been conducted in the past aiming to decipher the association of NNK with o...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10080564
更新日期:2019-07-26 00:00:00
abstract::White coat color in mammals has been selected several times during the domestication process. Numerous dog breeds are fixed for one form of white coat color that involves darkly pigmented skin. The genetic basis of this color, due to the absence of pigment in the hairs, was suggested to correspond to extreme dilution ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050386
更新日期:2019-05-21 00:00:00
abstract::We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of heroin use and from con...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8060152
更新日期:2017-05-30 00:00:00
abstract::RNA-binding proteins (RBPs) are important regulators of cellular functions, playing critical roles on the survival of bacteria and in the case of pathogens, on their interaction with the host. RBPs are involved in transcriptional, post-transcriptional, and translational processes. However, except for model organisms l...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020231
更新日期:2020-02-21 00:00:00
abstract::Maize kernel development is a complex biological process that involves the temporal and spatial expression of many genes and fine gene regulation at a transcriptional and post-transcriptional level, and microRNAs (miRNAs) play vital roles during this process. To gain insight into miRNA-mediated regulation of maize ker...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120385
更新日期:2017-12-14 00:00:00
abstract::Prader-Willi Syndrome Association (USA) monitors the ongoing health and welfare of individuals with Prader-Willi syndrome (PWS) through active communication with members by membership surveys and data registries. Thromboembolism and blood clots have emerged in clinical studies as significant risk factors for injury an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10070550
更新日期:2019-07-19 00:00:00
abstract::Balanced chromosome rearrangements are one of the main etiological factors contributing to hypoprolificacy in the domestic pig. Amongst domestic animals, the pig is considered to have the highest prevalence of chromosome rearrangements. To date over 200 unique chromosome rearrangements have been identified. The factor...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100769
更新日期:2019-09-30 00:00:00
abstract::Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060418
更新日期:2019-05-30 00:00:00
abstract::Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100817
更新日期:2019-10-17 00:00:00
abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100269
更新日期:2017-10-13 00:00:00
abstract::The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes12020129
更新日期:2021-01-20 00:00:00
abstract::The revolution in next-generation DNA sequencing technologies is leading to explosive data growth in genomics, posing a significant challenge to the computing infrastructure and software algorithms for genomics analysis. Various big data technologies have been explored to scale up/out current bioinformatics solutions ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10121017
更新日期:2019-12-06 00:00:00
abstract::RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11121420
更新日期:2020-11-27 00:00:00
abstract::Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmo...
journal_title:Genes
pub_type:
doi:10.3390/genes7120108
更新日期:2016-11-29 00:00:00
abstract::Recent advances in next-generation sequencing technology have led to the production of an unprecedented volume of genomic data, thus further advancing our understanding of the role of genetic variation in clinical pharmacogenomics. In the present study, we used whole exome sequencing data from 50,726 participants, as ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050561
更新日期:2020-05-18 00:00:00
abstract::Genome wide association studies (GWAS) are a well established methodology to identify genomic variants and genes that are responsible for traits of interest in all branches of the life sciences. Despite the long time this methodology has had to mature the reliable detection of genotype-phenotype associations is still ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080892
更新日期:2020-08-05 00:00:00
abstract::(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) and integral membrane protein 2A (ITM2A) on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphism...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080858
更新日期:2020-07-27 00:00:00
abstract::Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060689
更新日期:2020-06-24 00:00:00
abstract::In the years since the first complete human genome sequence was reported, there has been a rapid development of technologies to facilitate high-throughput sequence analysis of DNA (termed "next-generation" sequencing). These novel approaches to DNA sequencing offer the promise of complete genomic analysis at a cost fe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes1010038
更新日期:2010-05-25 00:00:00
abstract::The integration of phenotypes and genotypes is at an unprecedented level and offers new opportunities to establish deep phenotypes. There are a number of challenges to overcome, specifically, accelerated growth of data, data silos, incompleteness, inaccuracies, and heterogeneity within and across data sources. This pe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010018
更新日期:2018-12-28 00:00:00