Applications of Yeast Synthetic Biology Geared towards the Production of Biopharmaceuticals.

abstract：:Several transcription factors (TFs) coordinate to regulate expression of specific genes at the transcriptional level. In Arabidopsis thaliana it is estimated that approximately 10% of all genes encode TFs or TF-like proteins. It is important to identify target genes that are directly regulated by TFs in order to under...

journal_title：Genes

authors： Kurihara Y,Makita Y,Kawashima M,Hamasaki H,Yamamoto YY,Matsui M

更新日期：2014-12-19 00:00:00

abstract：:MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-transcriptional gene regulators. They can inhibit target protein-coding genes, through repressing messenger RNA (mRNA) translation or promoting their degradation. miRNAs were initially found to be originated from nuclear genome an...

journal_title：Genes

authors： Duarte FV,Palmeira CM,Rolo AP

更新日期：2014-09-26 00:00:00

abstract：:Soil salinity is a serious threat to plant growth and crop productivity. Tall fescue utilization in saline areas is limited by its inferior salt tolerance. Thus, a transcriptome study is a prerequisite for future research aimed at providing deeper insights into the molecular mechanisms of tall fescue salt tolerance as...

journal_title：Genes

authors： Amombo E,Li X,Wang G,An S,Wang W,Fu J

更新日期：2018-09-21 00:00:00

abstract：:Genetic adaptation to extremes is a fascinating topic. Nevertheless, few studies have explored the genetic adaptation of closely related species respectively inhabiting distinct extremes. With deep transcriptome sequencing, we attempt to detect the genetic architectures of tadpoles of five closely related toad species...

journal_title：Genes

authors： Chang L,Zhu W,Shi S,Zhang M,Jiang J,Li C,Xie F,Wang B

更新日期：2020-01-22 00:00:00

abstract：:The impacts and interactions between hatchery-bred fish and wild fish populations has been a topic of active investigation in recent decades. In some instances, the benefits of stocking can be overshadowed by negative effects such as genetic introgression with natural populations, loss of genetic diversity, and diluti...

journal_title：Genes

authors： Bernaś R,Poćwierz-Kotus A,Árnyasi M,Kent MP,Lien S,Wenne R

更新日期：2020-02-10 00:00:00

abstract：:The performance of genomic prediction (GP) on genetically correlated traits can be improved through an interdependence multi-trait model under a multi-environment context. In this study, a panel of 237 soft facultative wheat (Triticumaestivum L.) lines was evaluated to compare single- and multi-trait models for predic...

journal_title：Genes

authors： Guo J,Khan J,Pradhan S,Shahi D,Khan N,Avci M,Mcbreen J,Harrison S,Brown-Guedira G,Murphy JP,Johnson J,Mergoum M,Esten Mason R,Ibrahim AMH,Sutton R,Griffey C,Babar MA

更新日期：2020-10-28 00:00:00

abstract：:Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describ...

journal_title：Genes

authors： Damiati S,Peacock M,Leonhardt S,Damiati L,Baghdadi MA,Becker H,Kodzius R,Schuster B

更新日期：2018-02-14 00:00:00

abstract：:: The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar proteins being encoded in the cell nuclear genome and traffick...

journal_title：Genes

authors： Mallo N,Fellows J,Johnson C,Sheiner L

更新日期：2018-08-14 00:00:00

abstract：:In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...

journal_title：Genes

authors： Hadjadj L,Riziki T,Zhu Y,Li J,Diene SM,Rolain JM

更新日期：2017-12-19 00:00:00

abstract：:The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are...

journal_title：Genes

authors： Ghanemi A,Melouane A,Yoshioka M,St-Amand J

更新日期：2020-07-31 00:00:00

abstract：:It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and t...

journal_title：Genes

authors： Pickard MR,Williams GT

更新日期：2015-07-07 00:00:00

abstract：:Plant genomes generated by Sanger and Next Generation Sequencing (NGS) have provided insight into species diversity and evolution. However, Sanger sequencing is limited in its applications due to high cost, labor intensity, and low throughput, while NGS reads are too short to resolve abundant repeats and polyploidy, l...

journal_title：Genes

authors： Li C,Lin F,An D,Wang W,Huang R

更新日期：2017-12-28 00:00:00

abstract：:Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...

journal_title：Genes

authors： Xia X

更新日期：2020-08-25 00:00:00

abstract：:The wall-associated kinase (WAK) and wall-associated kinase like (WAKL) is a subfamily of receptor-like kinases associated with the cell wall, which have been suggested as sensors of the extracellular environment and triggers of intracellular signals. However, these proteins have not yet been comprehensively analyzed ...

journal_title：Genes

authors： Sun Z,Song Y,Chen D,Zang Y,Zhang Q,Yi Y,Qu G

更新日期：2020-10-12 00:00:00

abstract：:The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding ...

journal_title：Genes

authors： Cui J,Liu X,Yang L,Che S,Guo H,Han J,Zhu Z,Cao B,An X,Zhang L,Song Y

更新日期：2020-09-07 00:00:00

abstract：:The development of high-throughput sequencing technologies and screening of big patient cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification of a significant number of genetic variants, which are sometimes difficult to interpret. The American College of Medical Genetics and ...

journal_title：Genes

authors： Lattante S,Marangi G,Doronzio PN,Conte A,Bisogni G,Zollino M,Sabatelli M

更新日期：2020-09-24 00:00:00

abstract：:The spread of food allergens is a topic of global importance due to its impact on public health. National and International regulations ask food producers and manufacturers to declare product compositions on the label, especially in case of processed raw materials. Wheat flour (Triticum aestivum) can be contaminated b...

journal_title：Genes

authors： Frigerio J,Pellesi R,Mezzasalma V,De Mattia F,Galimberti A,Lambertini F,Suman M,Zanardi S,Leporati A,Labra M

更新日期：2019-03-19 00:00:00

abstract：:Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...

journal_title：Genes

authors： Shao F,Liu J,Ren M,Li J,Bao H,Wu C

更新日期：2019-05-30 00:00:00

abstract：:More than fifteen genetic diseases, including Huntington's disease, myotonic dystrophy 1, fragile X syndrome and Friedreich ataxia, are caused by the aberrant expansion of a trinucleotide repeat. The mutation is unstable and further expands in specific cells or tissues with time, which can accelerate disease progressi...

journal_title：Genes

authors： Goula AV,Merienne K

更新日期：2013-07-25 00:00:00

abstract：:Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN i...

journal_title：Genes

authors： Fusco N,Sajjadi E,Venetis K,Gaudioso G,Lopez G,Corti C,Rocco EG,Criscitiello C,Malapelle U,Invernizzi M

更新日期：2020-06-28 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease with X-linked recessive inheritance, that leads patients to premature death. The loss of dystrophin determines membrane instability, causing cell damage and inflammatory response. Macrophage migration inhibitory factor (MIF) is a cytokine t...

journal_title：Genes

authors： Lombardo SD,Mazzon E,Mangano K,Basile MS,Cavalli E,Mammana S,Fagone P,Nicoletti F,Petralia MC

更新日期：2019-11-18 00:00:00

abstract：:We report the development of a multigene gene expression assay on the BioMark HD platform for the evaluation of immune competence (ImCom) in farmed Atlantic salmon. The first version of the assay included 92 genes selected on the basis of transcriptome analyses in 54 trials that challenged the immune system; annotatio...

journal_title：Genes

authors： Krasnov A,Afanasyev S,Nylund S,Rebl A

更新日期：2020-10-22 00:00:00

abstract：:Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational...

journal_title：Genes

authors： Edwards AM,Addo MA,Dos Santos PC

更新日期：2020-08-07 00:00:00

abstract：:Monogenic forms of beta cell diabetes account for approximately 1%-2% of all cases of diabetes, yet remain underdiagnosed. Overlapping clinical features with common forms of diabetes, make diagnosis challenging. A genetic diagnosis of monogenic diabetes in many cases alters therapy, affects prognosis, enables genetic ...

journal_title：Genes

authors： Carroll RW,Murphy R

更新日期：2013-09-26 00:00:00

abstract：:The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their m...

journal_title：Genes

authors： Sánchez-González R,Figueres-Oñate M,Ojalvo-Sanz AC,López-Mascaraque L

更新日期：2020-03-13 00:00:00

abstract：:A 9-month old male Jack Russell Terrier started showing paraparesis of the hindlimbs after a walk. Hospitalized, the dog went into cardiac arrest, and later died. Necroscopic examination revealed a severe thickness of the diaphragm, esophagus, and base of the tongue, leading to the diagnosis of muscular dystrophy. The...

journal_title：Genes

authors： Brunetti B,Muscatello LV,Letko A,Papa V,Cenacchi G,Grillini M,Murgiano L,Jagannathan V,Drögemüller C

更新日期：2020-10-08 00:00:00

abstract：:Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of...

journal_title：Genes

authors： Ravaioli F,Bacalini MG,Franceschi C,Garagnani P

更新日期：2018-01-16 00:00:00

abstract：:White mold (WM) is a devastating fungal disease affecting common bean (Phaseolus vulgaris L.). In this research, a genome-wide association study (GWAS) for WM resistance was conducted using 294 lines of the Spanish diversity panel. One single-locus method and six multi-locus methods were used in the GWAS. Response to ...

journal_title：Genes

authors： Campa A,García-Fernández C,Ferreira JJ

更新日期：2020-12-12 00:00:00

abstract：:Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic...

journal_title：Genes

authors： Floriano B,Santero E,Reyes-Ramírez F

更新日期：2019-05-06 00:00:00

abstract：:We analysed nine microsatellite markers for 626 individuals representing the geographic range of eight closely related endemic New Zealand species of Sophora. Structure analysis identified the optimal K value as seven, with samples identified as Sophorachathamica, Sophorafulvida, Sophoralongicarinata, and Sophoraprost...

journal_title：Genes

authors： Heenan P,Mitchell C,Houliston G

更新日期：2018-02-20 00:00:00