PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?

Abstract:

:Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN is deeply involved in cell growth, proliferation, and survival. This gene is also implicated in the modulation of the DNA damage response and in tumor immune microenvironment modeling. Despite the actionability of PTEN alterations, their role as biomarkers remains controversial in clinical practice. To date, there is still a substantial lack of validated guidelines and/or recommendations for PTEN testing. Here, we provide an update on the current state of knowledge on biologic and genetic alterations of PTEN across the most frequent solid tumors, as well as on their actual and/or possible clinical applications. We focus on possible tailored schemes for cancer patients' clinical management, including risk assessment, diagnosis, prognostication, and treatment.

journal_name

Genes (Basel)

journal_title

Genes

authors

Fusco N,Sajjadi E,Venetis K,Gaudioso G,Lopez G,Corti C,Rocco EG,Criscitiello C,Malapelle U,Invernizzi M

doi

10.3390/genes11070719

subject

Has Abstract

pub_date

2020-06-28 00:00:00

issue

7

issn

2073-4425

pii

genes11070719

journal_volume

11

pub_type

杂志文章,评审

相关文献

Genes文献大全
  • Further Insights into the Architecture of the PN Promoter That Controls the Expression of the bzd Genes in Azoarcus.

    abstract::The anaerobic degradation of benzoate in bacteria involves the benzoyl-CoA central pathway. Azoarcus/Aromatoleum strains are a major group of anaerobic benzoate degraders, and the transcriptional regulation of the bzd genes was extensively studied in Azoarcus sp. CIB. In this work, we show that the bzdR regulatory gen...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10070489

    authors: Durante-Rodríguez G,Gutiérrez-Del-Arroyo P,Vélez M,Díaz E,Carmona M

    更新日期:2019-06-27 00:00:00

  • Identification of Loci Controlling the Dwarfism Trait in the White Sailfin Molly (Poecilia latipinna) Using Genome-Wide Association Studies Based on Genotyping-By-Sequencing.

    abstract::Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10060418

    authors: Shao F,Liu J,Ren M,Li J,Bao H,Wu C

    更新日期:2019-05-30 00:00:00

  • TYK2 Variants in B-Acute Lymphoblastic Leukaemia.

    abstract::B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN-α/β receptor alpha chain (IF...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121434

    authors: Turrubiartes-Martínez E,Bodega-Mayor I,Delgado-Wicke P,Molina-Jiménez F,Casique-Aguirre D,González-Andrade M,Rapado I,Camós M,Díaz-de-Heredia C,Barragán E,Ramírez-Orellana M,Aguado B,Figuera Á,Martínez-López J,Fernández-Ruiz

    更新日期:2020-11-28 00:00:00

  • A Genetic Population Isolate in The Netherlands Showing Extensive Haplotype Sharing and Long Regions of Homozygosity.

    abstract::Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fert...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8050133

    authors: Somers M,Olde Loohuis LM,Aukes MF,Pasaniuc B,de Visser KCL,Kahn RS,Sommer IE,Ophoff RA

    更新日期:2017-05-04 00:00:00

  • Model-Based Clustering with Measurement or Estimation Errors.

    abstract::Model-based clustering with finite mixture models has become a widely used clustering method. One of the recent implementations is MCLUST. When objects to be clustered are summary statistics, such as regression coefficient estimates, they are naturally associated with estimation errors, whose covariance matrices can o...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11020185

    authors: Zhang W,Di Y

    更新日期:2020-02-10 00:00:00

  • Beyond junk-variable tandem repeats as facilitators of rapid evolution of regulatory and coding sequences.

    abstract::Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes3030461

    authors: Gemayel R,Cho J,Boeynaems S,Verstrepen KJ

    更新日期:2012-07-26 00:00:00

  • Cryptic Diversity Hidden within the Leafminer Genus Liriomyza (Diptera: Agromyzidae).

    abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9110554

    authors: Carapelli A,Soltani A,Leo C,Vitale M,Amri M,Mediouni-Ben Jemâa J

    更新日期:2018-11-15 00:00:00

  • Epitranscriptomic Signatures in lncRNAs and Their Possible Roles in Cancer.

    abstract::In contrast to the amazing exponential growth in knowledge related to long non-coding RNAs (lncRNAs) involved in cell homeostasis or dysregulated pathological states, little is known so far about the links between the chemical modifications occurring in lncRNAs and their function. Generally, ncRNAs are post-transcript...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes10010052

    authors: Dinescu S,Ignat S,Lazar AD,Constantin C,Neagu M,Costache M

    更新日期:2019-01-16 00:00:00

  • Non-Random Distribution of Reciprocal Translocation Breakpoints in the Pig Genome.

    abstract::Balanced chromosome rearrangements are one of the main etiological factors contributing to hypoprolificacy in the domestic pig. Amongst domestic animals, the pig is considered to have the highest prevalence of chromosome rearrangements. To date over 200 unique chromosome rearrangements have been identified. The factor...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10100769

    authors: Donaldson B,Villagomez DAF,Revay T,Rezaei S,King WA

    更新日期:2019-09-30 00:00:00

  • Female Choice Undermines the Emergence of Strong Sexual Isolation between Locally Adapted Populations of Atlantic Mollies (Poecilia mexicana).

    abstract::Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate ch...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9050232

    authors: Zimmer C,Riesch R,Jourdan J,Bierbach D,Arias-Rodriguez L,Plath M

    更新日期:2018-05-02 00:00:00

  • Characterization, Knockdown and Parental Effect of Hexokinase Gene of Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) Revealed by RNA Interference.

    abstract::Hexokinase (HK) is a key enzyme in chitin biosynthesis in insects and plays an important role in development and energy regulation. It also performs a crucial role in the synthesis of Glucose-6-phosphate and its putative functions are studied via injection of dsRNA corresponding to the hexokinase gene from Cnaphalocro...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111258

    authors: Shakeel M,Du J,Li SW,Zhou YJ,Sarwar N,Bukhari SAH

    更新日期:2020-10-26 00:00:00

  • The role of bromodomain proteins in regulating gene expression.

    abstract::Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes3020320

    authors: Josling GA,Selvarajah SA,Petter M,Duffy MF

    更新日期:2012-05-29 00:00:00

  • Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity.

    abstract::Biogerontological research highlighted a complex and dynamic connection between aging, health and longevity, partially determined by genetic factors. Multifunctional proteins with moonlighting features, by integrating different cellular activities in the space and time, may explain part of this complexity. Inositol Po...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10020125

    authors: De Rango F,Crocco P,Iannone F,Saiardi A,Passarino G,Dato S,Rose G

    更新日期:2019-02-08 00:00:00

  • PPARGC1A rs8192678 and NRF1 rs6949152 Polymorphisms Are Associated with Muscle Fiber Composition in Women.

    abstract::PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11091012

    authors: Yvert T,Miyamoto-Mikami E,Tobina T,Shiose K,Kakigi R,Tsuzuki T,Takaragawa M,Ichinoseki-Sekine N,Pérez M,Kobayashi H,Tanaka H,Naito H,Fuku N

    更新日期:2020-08-27 00:00:00

  • Non-Additive Transcriptomic Responses to Inoculation with Rhizobia in a Young Allopolyploid Compared with Its Diploid Progenitors.

    abstract::Root nodule symbioses (nodulation) and whole genome duplication (WGD, polyploidy) are both important phenomena in the legume family (Leguminosae). Recently, it has been proposed that polyploidy may have played a critical role in the origin or refinement of nodulation. However, while nodulation and polyploidy have been...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8120357

    authors: Powell AF,Doyle JJ

    更新日期:2017-11-30 00:00:00

  • The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population.

    abstract::The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11101192

    authors: León-Reyes G,Rivera-Paredez B,López JCF,Ramírez-Salazar EG,Aquino-Gálvez A,Gallegos-Carrillo K,Denova-Gutiérrez E,Salmerón J,Velázquez-Cruz R

    更新日期:2020-10-14 00:00:00

  • Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing-G/C Substitution Stabilizes GuideRNAs against Editing.

    abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8010034

    authors: Heep M,Mach P,Reautschnig P,Wettengel J,Stafforst T

    更新日期:2017-01-14 00:00:00

  • Domesticated gag Gene of Drosophila LTR Retrotransposons Is Involved in Response to Oxidative Stress.

    abstract::Drosophila melanogaster is one of the most extensively used genetic model organisms for studying LTR retrotransposons that are represented by various groups in its genome. However, the phenomenon of molecular domestication of LTR retrotransposons has been insufficiently studied in Drosophila, as well as in other inver...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11040396

    authors: Makhnovskii P,Balakireva Y,Nefedova L,Lavrenov A,Kuzmin I,Kim A

    更新日期:2020-04-06 00:00:00

  • A Transcriptome Analysis Identifies Biological Pathways and Candidate Genes for Feed Efficiency in DLY Pigs.

    abstract::Feed cost accounts for approximately 65-75% of overall commercial pork production costs. Therefore, improving the feed efficiency of pig production is important. In this study, 12 individuals with either extremely high (HE) or low (LE) feed efficiency were selected from 225 Duroc × (Landrace × Yorkshire) (DLY) pigs. A...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10090725

    authors: Wang X,Li S,Wu J,Ding R,Quan J,Zheng E,Yang J,Wu Z

    更新日期:2019-09-18 00:00:00

  • Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer.

    abstract::Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIMPs) are continually being implicated in tumorigenesis, but these conn...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111384

    authors: Wang J,Vallee I,Dutta A,Wang Y,Mo Z,Liu Z,Cui H,Su AI,Yang XL

    更新日期:2020-11-22 00:00:00

  • Patterns, Mechanisms and Genetics of Speciation in Reptiles and Amphibians.

    abstract::In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study assesses how patterns and processes of speciation depend on knowing the taxonomy of the group in question, and discuss how integrative taxonomy has contributed...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes10090646

    authors: Wollenberg Valero KC,Marshall JC,Bastiaans E,Caccone A,Camargo A,Morando M,Niemiller ML,Pabijan M,Russello MA,Sinervo B,Werneck FP,Sites JW,Jr.,Wiens JJ,Steinfartz S

    更新日期:2019-08-26 00:00:00

  • Can Genetic Testing Identify Talent for Sport?

    abstract::Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is consider...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes10120972

    authors: Pickering C,Kiely J,Grgic J,Lucia A,Del Coso J

    更新日期:2019-11-26 00:00:00

  • An Independent Locus Upstream of ASIP Controls Variation in the Shade of the Bay Coat Colour in Horses.

    abstract::Novel coat colour phenotypes often emerge during domestication, and there is strong evidence of genetic selection for the two main genes that control base coat colour in horses-ASIP and MC1R. These genes direct the type of pigment produced, red pheomelanin (MC1R) or black eumelanin (ASIP), as well as the relative conc...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11060606

    authors: Corbin LJ,Pope J,Sanson J,Antczak DF,Miller D,Sadeghi R,Brooks SA

    更新日期:2020-05-30 00:00:00

  • Review of the Application of Modern Cytogenetic Methods (FISH/GISH) to the Study of Reticulation (Polyploidy/Hybridisation).

    abstract::The convergence of distinct lineages upon interspecific hybridisation, including when accompanied by increases in ploidy (allopolyploidy), is a driving force in the origin of many plant species. In plant breeding too, both interspecific hybridisation and allopolyploidy are important because they facilitate introgressi...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes1020166

    authors: Chester M,Leitch AR,Soltis PS,Soltis DE

    更新日期:2010-07-02 00:00:00

  • Extracurricular Functions of tRNA Modifications in Microorganisms.

    abstract::Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11080907

    authors: Edwards AM,Addo MA,Dos Santos PC

    更新日期:2020-08-07 00:00:00

  • Combining Random Forests and a Signal Detection Method Leads to the Robust Detection of Genotype-Phenotype Associations.

    abstract::Genome wide association studies (GWAS) are a well established methodology to identify genomic variants and genes that are responsible for traits of interest in all branches of the life sciences. Despite the long time this methodology has had to mature the reliable detection of genotype-phenotype associations is still ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11080892

    authors: Ramzan F,Gültas M,Bertram H,Cavero D,Schmitt AO

    更新日期:2020-08-05 00:00:00

  • Comparison of the fecal microbiota in feral and domestic goats.

    abstract::Animals have co-evolved with mutualistic microbial communities, known as the microbiota, which are essential for organ development and function. We hypothesize that modern animal husbandry practices exert an impact on the intestinal microbiota. In this study, we compared the structure of the fecal microbiota between f...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes3010001

    authors: De Jesús-Laboy KM,Godoy-Vitorino F,Piceno YM,Tom LM,Pantoja-Feliciano IG,Rivera-Rivera MJ,Andersen GL,Domínguez-Bello MG

    更新日期:2011-12-21 00:00:00

  • DynSig: Modelling Dynamic Signaling Alterations along Gene Pathways for Identifying Differential Pathways.

    abstract::Although a number of methods have been proposed for identifying differentially expressed pathways (DEPs), few efforts consider the dynamic components of pathway networks, i.e., gene links. We here propose a signaling dynamics detection method for identification of DEPs, DynSig, which detects the molecular signaling ch...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9070323

    authors: Shi M,Chong Y,Shen W,Xie XP,Wang HQ

    更新日期:2018-06-27 00:00:00

  • Functional Anthocyanin-Rich Sausages Diminish Colorectal Cancer in an Animal Model and Reduce Pro-Inflammatory Bacteria in the Intestinal Microbiota.

    abstract::Colorectal cancer is the fourth most common neoplasia in Europe, where it accounts for 28.2 new cases per 100,000 inhabitants. In an effort to decrease the incidence of this disease, various prevention measures are being studied, one of which are anthocyanin-rich foods. Anthocyanins are potent antioxidant flavonoids m...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9030133

    authors: Fernández J,García L,Monte J,Villar CJ,Lombó F

    更新日期:2018-03-01 00:00:00

  • CNV Detection from Circulating Tumor DNA in Late Stage Non-Small Cell Lung Cancer Patients.

    abstract::While methods for detecting SNVs and indels in circulating tumor DNA (ctDNA) with hybridization capture-based next-generation sequencing (NGS) have been available, copy number variations (CNVs) detection is more challenging. Here, we present a method enabling CNV detection from a 150-gene panel using a very low amount...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10110926

    authors: Peng H,Lu L,Zhou Z,Liu J,Zhang D,Nan K,Zhao X,Li F,Tian L,Dong H,Yao Y

    更新日期:2019-11-14 00:00:00